GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
MOSC - MOSC domain
Pfam: PF03473 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 133
Sequences: 2352
Seq/Len: 17.68
HH_delta: 0.237 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
67_R76_E0.812173.136
69_R132_E0.712812.753
75_L117_A0.695152.684
126_R129_D0.657472.539
76_E118_R0.640132.472
69_R74_V0.627262.422
67_R74_V0.606262.341
74_V121_K0.603562.331
23_L117_A0.586232.264
26_Q30_D0.569962.201
76_E120_I0.566362.187
21_V75_L0.521612.014
70_I131_V0.509031.966
22_S81_C0.498731.926
31_A35_R0.498051.923
19_R116_Y0.425661.644
50_I125_I0.424191.638
67_R120_I0.412711.594
56_P62_D0.410161.584
31_A34_A0.401981.552
52_V131_V0.400891.548
27_E54_G0.381581.473
23_L52_V0.377481.458
68_L77_V0.374941.448
77_V117_A0.369011.425
29_L43_P0.362881.401
27_E53_D0.356951.378
48_P51_V0.351921.359
72_D124_T0.344981.332
119_V123_G0.343431.326
69_R121_K0.342021.321
77_V115_V0.34191.320
29_L51_V0.338481.307
33_N39_P0.337011.301
70_I125_I0.330761.277
26_Q53_D0.326231.260
74_V120_I0.321491.241
30_D34_A0.315971.220
35_R106_Q0.312731.208
104_F108_A0.311451.203
19_R78_T0.306821.185
44_R91_P0.300311.160
30_D53_D0.299351.156
30_D33_N0.291531.126
79_Q116_Y0.290221.121
86_M91_P0.283351.094
63_W68_L0.280121.082
50_I70_I0.279291.078
25_S28_S0.274131.059
28_S60_E0.269351.040
24_I43_P0.269091.039
85_V88_N0.267471.033
60_E63_W0.267451.033
21_V119_V0.26561.026
73_A125_I0.262651.014
55_L63_W0.261361.009
32_L46_F0.258390.998
69_R72_D0.256220.989
25_S52_V0.25620.989
75_L119_V0.249820.965
37_G40_G0.24960.964
18_E79_Q0.248310.959
42_D45_R0.242550.937
24_I29_L0.241140.931
87_P91_P0.239610.925
70_I129_D0.239170.924
71_G129_D0.236680.914
22_S116_Y0.231110.892
91_P96_R0.230250.889
70_I75_L0.226010.873
33_N37_G0.221980.857
83_R87_P0.219890.849
24_I32_L0.217010.838
120_I123_G0.216550.836
90_D93_T0.2150.830
47_R81_C0.214740.829
89_V94_G0.213230.823
17_D20_P0.213210.823
45_R91_P0.211710.818
52_V55_L0.210040.811
72_D121_K0.208340.805
78_T118_R0.206440.797
127_V130_E0.202550.782
34_A37_G0.202450.782
38_E92_D0.201870.780
26_Q43_P0.199980.772
73_A123_G0.198740.767
28_S113_R0.19840.766
25_S60_E0.197920.764
27_E55_L0.197250.762
47_R83_R0.195370.754
88_N104_F0.19280.745
96_R112_R0.192750.744
68_L131_V0.192640.744
42_D91_P0.191990.741
19_R79_Q0.190390.735
85_V96_R0.189290.731
119_V122_G0.189140.730
13_H16_G0.188620.728
89_V96_R0.186590.721
44_R48_P0.185730.717
18_E22_S0.185440.716
33_N36_L0.18430.712
71_G123_G0.182660.705
73_A121_K0.182460.705
25_S55_L0.182020.703
23_L115_V0.181050.699
27_E52_V0.179910.695
105_G109_S0.177290.685
21_V123_G0.176720.682
91_P94_G0.176660.682
106_Q109_S0.175890.679
44_R92_D0.173520.670
113_R116_Y0.173140.669
104_F107_N0.173010.668
19_R86_M0.171880.664
71_G130_E0.170140.657
127_V131_V0.165080.637
28_S56_P0.164340.635
20_P29_L0.164310.634
32_L47_R0.163480.631
114_G119_V0.16290.629
27_E30_D0.162550.628
39_P67_R0.162520.628
28_S32_L0.162430.627
81_C113_R0.161370.623
114_G123_G0.161210.623
73_A119_V0.160150.618
86_M89_V0.159570.616
33_N45_R0.159230.615
28_S83_R0.157060.606
33_N40_G0.156270.603
85_V89_V0.156160.603
112_R115_V0.15480.598
28_S47_R0.154760.598
90_D95_E0.154040.595
46_F113_R0.153060.591
36_L40_G0.152790.590
22_S88_N0.15260.589
68_L117_A0.152290.588
83_R86_M0.151810.586
26_Q51_V0.151470.585
95_E106_Q0.148010.572
126_R132_E0.147810.571
80_P85_V0.147180.568
50_I127_V0.146740.567
18_E118_R0.14650.566
85_V111_G0.14580.563
90_D94_G0.145740.563
50_I75_L0.145460.562
61_D90_D0.145450.562
29_L47_R0.145410.562
47_R87_P0.144970.560
92_D130_E0.144640.559
91_P95_E0.1440.556
43_P51_V0.143570.554
81_C116_Y0.142440.550
105_G108_A0.142360.550
21_V67_R0.142090.549
47_R113_R0.142010.548
20_P116_Y0.141380.546
82_P116_Y0.141160.545
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1o65A0.924899.90.237
1oruA0.977499.90.292
3dwbA0.586513.70.924
3au7A0.834612.90.925
1r1hA0.586512.50.925
3vrhA0.3919.80.928
3zukA0.61659.40.929
3llpA0.84968.60.93
3ddyA0.62418.20.931
1i8dA0.63167.60.932

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