GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF295 - Protein of unknown function (DUF295)
Pfam: PF03478 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 54
Sequences: 462
Seq/Len: 8.56
HH_delta: 0.851 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
31_K53_N0.415592.783
9_D33_N0.314792.108
35_I52_Y0.298832.001
12_L20_F0.241131.615
31_K34_C0.224141.501
9_D25_S0.220021.473
20_F54_M0.215431.443
13_F50_G0.214441.436
6_S9_D0.203651.364
11_A36_Y0.194711.304
40_D50_G0.188111.260
27_F51_V0.186171.247
13_F40_D0.183371.228
23_S27_F0.180941.212
4_V11_A0.18011.206
40_D47_R0.178461.195
11_A32_G0.172141.153
22_V36_Y0.167281.120
37_F50_G0.162151.086
12_L21_S0.156431.048
24_A29_G0.15141.014
37_F48_D0.151381.014
14_L38_L0.148290.993
17_N52_Y0.147830.990
15_G32_G0.145980.978
38_L47_R0.145840.977
8_G49_I0.144330.967
2_V11_A0.144120.965
7_L54_M0.143680.962
16_R40_D0.143220.959
37_F40_D0.142490.954
14_L53_N0.141860.950
5_K45_S0.140840.943
38_L54_M0.13710.918
35_I54_M0.136520.914
21_S32_G0.133510.894
10_R34_C0.133230.892
10_R21_S0.132930.890
16_R21_S0.132550.888
19_S22_V0.128910.863
4_V25_S0.126990.850
32_G37_F0.126870.850
4_V37_F0.125910.843
15_G19_S0.125040.837
4_V12_L0.123160.825
37_F52_Y0.122730.822
17_N22_V0.121150.811
7_L15_G0.120960.810
4_V8_G0.119490.800
14_L40_D0.118470.793
38_L49_I0.118260.792
19_S39_D0.118220.792
5_K53_N0.117890.789
14_L44_E0.117260.785
4_V54_M0.11680.782
24_A48_D0.116340.779
30_L49_I0.1140.763
8_G35_I0.11390.763
17_N30_L0.11320.758
5_K25_S0.11290.756
8_G15_G0.112190.751
3_E24_A0.111850.749
19_S50_G0.111740.748
32_G39_D0.111320.745
7_L51_V0.110770.742
2_V26_D0.110440.740
13_F18_C0.109620.734
6_S20_F0.109290.732
27_F40_D0.109250.732
33_N39_D0.109050.730
17_N38_L0.108550.727
10_R22_V0.107940.723
6_S33_N0.107870.722
36_Y48_D0.107150.718
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
1pm3A0.333315.70.851
3m92A115.40.852
2eceA0.96312.70.857
1ofdA0.98157.50.87
4gpzA0.92595.30.878
4h6bA0.98155.10.879
2zwaA0.88894.50.882
2brjA0.98154.50.882
4djaA0.88894.40.882
4dzaA0.9634.20.883
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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