GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
CitMHS - Citrate transporter
Pfam: PF03600 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0182
Length: 351
Sequences: 11914
Seq/Len: 33.94
HH_delta: 0.278 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
282_E286_D0.881023.890
125_R131_P0.804273.551
243_D246_E0.748763.306
70_E246_E0.726623.209
101_A183_G0.674642.979
88_K91_R0.661782.922
334_Q340_P0.627312.770
108_D111_T0.606132.676
100_T116_M0.534442.360
283_A286_D0.514772.273
43_S46_E0.493292.178
80_K84_K0.486832.150
80_K83_R0.48592.146
283_A287_W0.485742.145
286_D290_S0.477082.107
333_A343_L0.472682.087
286_D289_L0.468412.068
273_G277_N0.458352.024
75_D79_R0.431581.906
232_G235_L0.420961.859
245_K249_R0.418531.848
181_I185_L0.414771.831
180_V184_L0.410141.811
279_G282_E0.402191.776
287_W291_I0.399831.766
66_A69_E0.399091.762
292_S296_G0.398541.760
96_L138_L0.394551.742
46_E277_N0.390171.723
189_F193_F0.386641.707
46_E49_S0.379441.675
70_E249_R0.374411.653
170_F174_A0.371211.639
246_E249_R0.370321.635
211_L215_L0.367181.621
94_L187_L0.366621.619
166_P171_D0.360911.594
193_F197_K0.357631.579
25_L267_G0.355871.571
76_W80_K0.35561.570
312_S315_P0.35171.553
316_A320_M0.350161.546
245_K248_Y0.343921.519
273_G276_S0.341821.509
178_P182_V0.334931.479
101_A180_V0.334861.479
120_V138_L0.332721.469
302_W306_L0.33061.460
72_G75_D0.329291.454
192_Y196_R0.327461.446
66_A70_E0.327131.444
96_L120_V0.322581.424
235_L239_T0.321711.421
330_I334_Q0.320191.414
28_A270_I0.318011.404
133_P137_P0.317041.400
331_S334_Q0.315251.392
287_W290_S0.314821.390
182_V186_V0.313181.383
171_D174_A0.312951.382
199_K202_L0.312211.379
285_A289_L0.310551.371
165_L341_L0.310231.370
231_I235_L0.309811.368
174_A178_P0.302031.334
108_D112_V0.300441.327
191_L195_F0.2991.320
207_F211_L0.295821.306
97_M141_A0.295111.303
276_S282_E0.294921.302
61_G229_L0.294491.300
82_V127_L0.29371.297
109_N112_V0.292661.292
105_A112_V0.290821.284
104_S145_G0.288821.275
205_S210_V0.288631.274
212_V216_V0.287381.269
94_L191_L0.284841.258
235_L238_L0.284481.256
93_L133_P0.284451.256
275_L280_A0.282521.248
306_L310_V0.281791.244
28_A274_A0.280591.239
149_T179_A0.280491.239
51_I266_A0.280011.236
109_N146_G0.278961.232
86_G91_R0.278891.231
200_P204_A0.278741.231
94_L188_I0.277171.224
122_S126_K0.275261.215
184_L188_I0.27441.212
187_L191_L0.273071.206
206_P210_V0.272061.201
67_A236_A0.270881.196
93_L137_P0.270871.196
79_R126_K0.270841.196
188_I192_Y0.270681.195
85_S95_L0.269271.189
136_M140_F0.268881.187
210_V214_I0.265761.174
244_L248_Y0.264591.168
137_P141_A0.263841.165
337_G340_P0.262861.161
160_A167_F0.262371.159
176_G180_V0.262011.157
151_I155_T0.261781.156
198_R202_L0.257471.137
338_V342_P0.256731.134
78_A120_V0.255061.126
235_L240_N0.254721.125
100_T141_A0.253341.119
294_P338_V0.253091.118
84_K201_K0.252921.117
145_G149_T0.252491.115
225_I228_A0.252181.114
104_S146_G0.251921.112
46_E273_G0.251271.110
171_D341_L0.250691.107
215_L218_L0.247381.092
100_T112_V0.246971.091
173_F176_G0.245741.085
123_L126_K0.245631.085
301_L346_A0.245151.083
264_F268_L0.244981.082
236_A239_T0.244841.081
42_I46_E0.243551.075
18_I23_A0.242541.071
93_L124_A0.240131.060
206_P217_L0.239521.058
69_E75_D0.239271.057
124_A134_L0.23851.053
155_T159_I0.238211.052
151_I154_P0.23681.046
224_P227_I0.236321.044
178_P181_I0.235951.042
60_F262_L0.234531.036
243_D248_Y0.234211.034
204_A207_F0.23391.033
289_L335_Q0.233781.032
155_T158_I0.233271.030
89_P195_F0.232191.025
295_L301_L0.232191.025
313_N316_A0.231261.021
171_D242_K0.231031.020
298_L302_W0.22931.013
113_V139_A0.228671.010
72_G76_W0.228531.009
244_L247_A0.228361.008
232_G236_A0.227431.004
160_A242_K0.227141.003
163_S330_I0.227041.003
104_S109_N0.226951.002
258_D262_L0.226270.999
83_R87_G0.226040.998
65_G74_F0.225680.997
233_A239_T0.225610.996
81_I84_K0.225250.995
123_L127_L0.224870.993
162_A317_T0.224650.992
205_S209_L0.22380.988
339_S342_P0.223620.987
189_F192_Y0.223210.986
113_V142_A0.223110.985
25_L270_I0.222930.984
107_L111_T0.222760.984
102_L106_F0.222640.983
207_F215_L0.221520.978
205_S217_L0.221370.977
233_A236_A0.221360.977
232_G240_N0.221180.977
141_A145_G0.22090.975
198_R201_K0.220550.974
193_F196_R0.219120.968
304_S308_S0.217570.961
223_V308_S0.217360.960
284_L287_W0.217270.959
79_R83_R0.216990.958
234_L239_T0.216190.955
183_G187_L0.215260.951
121_L134_L0.215210.950
315_P319_L0.214580.948
206_P211_L0.213450.943
143_N146_G0.213320.942
61_G228_A0.212110.937
87_G91_R0.212040.936
202_L205_S0.211570.934
138_L141_A0.21150.934
67_A247_A0.211480.934
133_P190_I0.211450.934
19_P23_A0.211240.933
121_L125_R0.210770.931
103_L112_V0.210620.930
231_I234_L0.210540.930
171_D241_C0.210150.928
200_P203_F0.209670.926
177_L181_I0.209380.925
256_S260_N0.207970.918
309_A315_P0.207680.917
234_L238_L0.207330.916
301_L305_A0.207260.915
42_I45_E0.20720.915
154_P159_I0.207180.915
79_R203_F0.206410.911
117_I121_L0.205970.909
69_E74_F0.204790.904
179_A182_V0.204080.901
92_L127_L0.20350.899
307_L316_A0.2030.896
19_P22_A0.202570.894
274_A278_T0.20210.892
333_A338_V0.201890.891
313_N317_T0.201460.890
232_G239_T0.201190.888
212_V215_L0.201060.888
279_G283_A0.201050.888
103_L117_I0.200860.887
215_L219_V0.20060.886
43_S277_N0.200380.885
210_V215_L0.199170.879
148_L177_L0.198910.878
288_L332_M0.198420.876
132_S135_L0.1980.874
110_T114_L0.197440.872
60_F64_I0.196680.868
146_G149_T0.196660.868
209_L212_V0.195460.863
326_L330_I0.195270.862
275_L281_F0.194460.859
112_V142_A0.194110.857
76_W79_R0.193760.856
101_A144_I0.193310.854
198_R203_F0.193280.853
81_I85_S0.19180.847
23_A27_G0.191230.844
315_P318_L0.191040.844
310_V315_P0.190970.843
161_N164_G0.190960.843
104_S149_T0.190920.843
44_P47_A0.19070.842
267_G271_F0.190460.841
330_I333_A0.190430.841
301_L304_S0.190110.839
45_E49_S0.189990.839
84_K87_G0.189710.838
140_F143_N0.189610.837
75_D126_K0.189430.836
116_M120_V0.189260.836
100_T104_S0.188370.832
266_A270_I0.188210.831
216_V220_S0.188190.831
118_P122_S0.187830.829
236_A240_N0.187050.826
139_A143_N0.186840.825
129_I134_L0.186660.824
314_V318_L0.186360.823
161_N171_D0.186240.822
305_A309_A0.185490.819
97_M187_L0.185410.819
233_A242_K0.185270.818
47_A270_I0.184280.814
99_V116_M0.18390.812
175_L341_L0.183840.812
144_I183_G0.18360.811
185_L188_I0.183360.810
165_L171_D0.18320.809
331_S335_Q0.183050.808
208_I212_V0.182620.806
316_A319_L0.182470.806
150_P160_A0.181940.803
298_L301_L0.181820.803
106_F109_N0.181570.802
249_R256_S0.18130.801
97_M184_L0.18080.798
309_A312_S0.180680.798
173_F177_L0.180660.798
85_S88_K0.180490.797
231_I239_T0.180380.796
138_L142_A0.180320.796
311_I316_A0.18030.796
100_T142_A0.180170.796
297_P338_V0.179910.794
105_A145_G0.179570.793
202_L206_P0.179470.792
199_K203_F0.179440.792
297_P336_F0.178880.790
263_L266_A0.178750.789
190_I193_F0.178690.789
201_K204_A0.178450.788
185_L189_F0.178440.788
259_W263_L0.177630.784
214_I218_L0.177610.784
342_P346_A0.177460.784
296_G299_A0.177430.783
104_S112_V0.175790.776
304_S309_A0.175580.775
290_S293_G0.175020.773
111_T261_T0.174930.772
332_M335_Q0.174910.772
120_V141_A0.174450.770
78_A82_V0.174390.770
24_A268_L0.174210.769
179_A183_G0.173550.766
281_F285_A0.173320.765
213_V217_L0.17270.763
329_A332_M0.172490.762
297_P300_I0.172140.760
81_I95_L0.172130.760
143_N154_P0.172080.760
171_D217_L0.171630.758
223_V226_W0.171530.757
144_I154_P0.171420.757
312_S316_A0.170530.753
59_L63_M0.170160.751
336_F343_L0.170060.751
170_F173_F0.169790.750
48_F52_D0.168890.746
203_F206_P0.168810.745
341_L344_A0.168640.745
240_N243_D0.168350.743
265_F314_V0.168290.743
207_F210_V0.1680.742
100_T145_G0.167790.741
192_Y195_F0.167550.740
97_M137_P0.167490.740
197_K306_L0.167410.739
175_L179_A0.167180.738
205_S215_L0.166870.737
78_A123_L0.166570.736
107_L112_V0.166530.735
21_V267_G0.166290.734
300_I333_A0.166270.734
50_F266_A0.166210.734
133_P197_K0.16620.734
146_G153_N0.166170.734
93_L97_M0.165920.733
213_V216_V0.165350.730
151_I158_I0.165230.730
58_L261_T0.165110.729
101_A149_T0.164890.728
18_I22_A0.164860.728
111_T115_I0.164260.725
327_P332_M0.163840.723
338_V346_A0.163490.722
329_A343_L0.162530.718
239_T242_K0.162460.717
159_I172_F0.16240.717
104_S108_D0.162150.716
55_T58_L0.161710.714
307_L310_V0.161250.712
79_R82_V0.160850.710
269_F273_G0.160720.710
121_L138_L0.160050.707
153_N157_L0.15990.706
110_T146_G0.159870.706
78_A267_G0.159820.706
165_L340_P0.159780.706
87_G201_K0.159510.704
280_A283_A0.159460.704
328_I331_S0.159270.703
308_S311_I0.158970.702
150_P173_F0.158920.702
80_K204_A0.157960.697
211_L214_I0.157240.694
28_A267_G0.156420.691
107_L149_T0.156070.689
289_L336_F0.155890.688
223_V227_I0.155880.688
235_L241_C0.155730.688
160_A241_C0.155530.687
209_L213_V0.154460.682
24_A271_F0.154340.682
98_L102_L0.154340.682
289_L292_S0.15420.681
234_L237_L0.153830.679
334_Q338_V0.153570.678
51_I57_I0.153420.677
243_D247_A0.153330.677
122_S125_R0.153320.677
40_G45_E0.153270.677
309_A313_N0.152760.675
201_K205_S0.152530.674
65_G268_L0.152350.673
105_A109_N0.152250.672
210_V232_G0.152160.672
329_A333_A0.151890.671
40_G43_S0.151720.670
302_W308_S0.151630.670
233_A238_L0.151550.669
17_K21_V0.151340.668
43_S47_A0.150790.666
109_N115_I0.150770.666
208_I216_V0.15050.665
297_P333_A0.150450.664
91_R94_L0.150430.664
21_V311_I0.149940.662
192_Y197_K0.14990.662
71_T74_F0.149690.661
112_V143_N0.149470.660
305_A311_I0.148990.658
16_K20_V0.148960.658
68_L71_T0.148850.657
208_I217_L0.148780.657
16_K24_A0.148490.656
94_L190_I0.148470.656
166_P170_F0.148450.656
242_K246_E0.148410.655
101_A116_M0.148380.655
158_I345_W0.148130.654
303_V307_L0.147840.653
258_D261_T0.147780.653
115_I145_G0.147650.652
210_V217_L0.147650.652
293_G296_G0.147640.652
214_I217_L0.147320.651
292_S295_L0.147320.651
144_I148_L0.147290.650
312_S317_T0.147230.650
78_A122_S0.147210.650
272_V279_G0.147190.650
304_S320_M0.146610.647
105_A219_V0.146590.647
163_S326_L0.14640.646
101_A105_A0.146380.646
135_L138_L0.146340.646
289_L293_G0.146280.646
104_S142_A0.146240.646
206_P209_L0.146130.645
206_P215_L0.145940.644
105_A108_D0.145880.644
338_V343_L0.145820.644
275_L326_L0.145610.643
194_L197_K0.14550.642
67_A242_K0.145390.642
47_A267_G0.145020.640
204_A217_L0.144860.640
285_A288_L0.144820.639
93_L190_I0.144720.639
207_F217_L0.144360.637
62_M232_G0.144210.637
41_V45_E0.143910.635
109_N143_N0.143570.634
56_L60_F0.143190.632
142_A145_G0.142550.629
144_I149_T0.142290.628
124_A137_P0.142140.628
106_F114_L0.142070.627
206_P216_V0.142010.627
156_N172_F0.1420.627
297_P301_L0.141650.625
42_I273_G0.141110.623
211_L218_L0.141070.623
64_I232_G0.140930.622
65_G114_L0.14060.621
282_E285_A0.139640.617
124_A131_P0.139580.616
49_S52_D0.139140.614
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4f35D0.94871000.278
4f35D0.535699.50.69
4g1uA0.529918.40.949
2nq2A0.532813.40.953
2l2tA0.12547.80.957
2qi9A0.51856.80.958
3ne5A0.45016.40.958
2ks1B0.125450.96
2jwaA0.12543.90.962
3nd0A0.900330.964

Page generated in 0.035 seconds.