GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
UPF0093 - Uncharacterised protein family (UPF0093)
Pfam: PF03653 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0430
Length: 147
Sequences: 1610
Seq/Len: 10.95
HH_delta: 0.899 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
8_L72_L0.475242.818
55_Y106_G0.441512.618
67_W99_V0.440312.611
140_I144_V0.406212.409
6_L9_K0.36522.165
94_L137_A0.357982.123
35_E121_A0.356512.114
33_H51_E0.34982.074
94_L141_L0.34422.041
89_H93_V0.342942.033
91_K142_V0.333611.978
65_L69_S0.331851.968
15_A65_L0.329911.956
48_A115_G0.326371.935
18_S62_A0.31861.889
13_I143_V0.317321.882
99_V103_G0.308171.827
100_A103_G0.306121.815
15_A69_S0.304811.807
11_L69_S0.304471.805
107_R111_R0.296831.760
16_V66_T0.29441.746
122_K126_I0.292251.733
94_L138_I0.282621.676
86_P89_H0.276191.638
112_L117_N0.266651.581
5_Y9_K0.254481.509
17_I135_L0.251881.494
111_R116_E0.251111.489
22_G59_M0.24271.439
71_L75_F0.241381.431
10_A140_I0.237241.407
104_W108_Y0.234511.391
90_V141_L0.233661.385
42_E45_E0.227031.346
134_L138_I0.226421.343
60_T64_I0.2231.322
137_A141_L0.220091.305
88_L92_L0.218991.299
36_A46_R0.210761.250
93_V100_A0.207181.228
43_F46_R0.205961.221
44_Y115_G0.201991.198
7_W11_L0.198191.175
15_A62_A0.196721.166
78_P82_W0.190181.128
11_L65_L0.189181.122
119_K123_F0.18651.106
74_L88_L0.185821.102
63_M99_V0.184921.096
42_E46_R0.184351.093
133_L137_A0.184191.092
82_W85_S0.184061.091
8_L144_V0.177031.050
22_G102_H0.175611.041
25_Y28_R0.174221.033
79_G84_S0.17361.029
86_P93_V0.172921.025
58_I62_A0.172161.021
5_Y82_W0.171971.020
87_W145_K0.170781.013
47_L51_E0.168370.998
117_N124_F0.166650.988
31_V124_F0.165380.981
104_W127_F0.16490.978
19_W66_T0.164530.976
10_A14_I0.16380.971
19_W91_K0.163480.969
100_A111_R0.162830.966
45_E48_A0.162180.962
9_K145_K0.161960.960
14_I136_I0.160020.949
82_W92_L0.15980.948
10_A139_V0.159610.946
4_Y8_L0.159170.944
95_V142_V0.156760.930
130_I134_L0.154430.916
49_I53_R0.154250.915
24_F101_Y0.154250.915
32_Y49_I0.153680.911
54_L101_Y0.152930.907
25_Y54_L0.152680.905
37_S44_Y0.151130.896
107_R116_E0.150010.889
127_F130_I0.149860.889
88_L142_V0.149250.885
103_G110_K0.149210.885
60_T102_H0.148610.881
89_H97_L0.148580.881
136_I144_V0.146960.871
9_K73_L0.1450.860
109_L113_A0.144930.859
34_A124_F0.144510.857
73_L82_W0.144310.856
66_T142_V0.144130.855
64_I68_I0.143770.852
47_L50_M0.143330.850
103_G106_G0.143230.849
79_G83_F0.143010.848
100_A107_R0.142890.847
141_L145_K0.142620.846
58_I61_P0.141550.839
83_F88_L0.140710.834
125_R129_E0.140430.833
17_I20_M0.139110.825
4_Y76_L0.137970.818
20_M135_L0.136770.811
112_L124_F0.136570.810
85_S88_L0.136240.808
60_T63_M0.136180.807
87_W142_V0.135470.803
71_L76_L0.135120.801
34_A121_A0.134090.795
103_G107_R0.133670.793
108_Y123_F0.133550.792
97_L134_L0.133540.792
36_A44_Y0.133360.791
91_K95_V0.132330.785
61_P64_I0.131540.780
78_P85_S0.131390.779
36_A42_E0.13130.779
114_R118_K0.130770.775
83_F86_P0.129380.767
82_W88_L0.128430.762
88_L141_L0.127910.758
65_L92_L0.127820.758
75_F110_K0.127630.757
4_Y77_N0.12720.754
78_P84_S0.126620.751
19_W26_L0.126590.751
16_V93_V0.126270.749
55_Y103_G0.125080.742
7_W140_I0.125060.742
119_K124_F0.124950.741
44_Y48_A0.124950.741
62_A132_T0.124390.738
95_V138_I0.1240.735
14_I139_V0.123810.734
97_L100_A0.123470.732
52_R57_I0.122980.729
32_Y58_I0.122460.726
68_I72_L0.12240.726
45_E118_K0.122150.724
7_W144_V0.122050.724
20_M50_M0.121670.721
49_I114_R0.120120.712
9_K143_V0.119750.710
128_N131_P0.119390.708
18_S25_Y0.118650.704
112_L119_K0.117680.698
16_V142_V0.117380.696
122_K133_L0.116740.692
29_L32_Y0.116590.691
125_R128_N0.116350.690
105_C127_F0.116130.689
13_I17_I0.1160.688
70_G124_F0.115480.685
74_L78_P0.115430.684
36_A43_F0.115390.684
43_F47_L0.115220.683
65_L103_G0.114790.681
17_I139_V0.114720.680
19_W102_H0.114510.679
8_L75_F0.114320.678
88_L95_V0.113820.675
69_S73_L0.113770.675
84_S89_H0.113430.673
32_Y50_M0.113310.672
124_F127_F0.113090.671
111_R118_K0.112970.670
10_A144_V0.112370.666
35_E53_R0.112240.666
60_T103_G0.112090.665
74_L83_F0.111950.664
4_Y42_E0.111460.661
23_L99_V0.111160.659
11_L136_I0.110860.657
111_R117_N0.110680.656
61_P132_T0.110650.656
125_R131_P0.110640.656
93_V123_F0.11050.655
101_Y105_C0.11020.653
31_V34_A0.109980.652
50_M53_R0.10970.650
13_I87_W0.10960.650
37_S48_A0.109550.650
28_R128_N0.109520.649
23_L135_L0.10930.648
97_L143_V0.109260.648
67_W91_K0.109090.647
90_V140_I0.109050.647
108_Y119_K0.108940.646
105_C126_I0.108780.645
25_Y50_M0.10850.643
21_A28_R0.108320.642
73_L83_F0.108260.642
94_L126_I0.108190.642
42_E76_L0.107970.640
55_Y59_M0.107950.640
68_I117_N0.107580.638
96_L100_A0.107510.637
111_R121_A0.107330.636
94_L134_L0.10690.634
5_Y78_P0.106210.630
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2xq2A0.96620.60.899
4ainA0.734711.20.91
3ayfA0.9325.60.921
1eysL0.59863.90.926
3o0rB0.87073.70.927
2wswA0.72113.10.93
3dinE0.469430.93
2kncB0.23812.30.934
4i9wA0.38782.20.935
2akhX0.47622.10.935
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