GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
TRAM_LAG1_CLN8 - TLC domain
Pfam: PF03798 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 198
Sequences: 1236
Seq/Len: 6.24
HH_delta: 0.962 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
144_F193_F0.280382.997
113_L139_F0.242932.596
49_Y90_S0.197462.110
19_G48_Y0.192092.053
139_F196_I0.191792.050
28_E31_S0.188122.011
49_Y99_G0.180351.928
144_F149_V0.173051.850
107_E110_T0.167151.787
130_S134_F0.153971.646
56_F59_D0.153451.640
145_V149_V0.148421.586
52_S56_F0.145571.556
119_L129_S0.145521.555
109_S143_F0.14031.500
106_H110_T0.140161.498
8_S114_N0.139831.495
83_T86_L0.13981.494
159_Y179_L0.139451.490
53_L84_L0.139091.487
127_K131_L0.136791.462
12_A110_T0.136371.458
8_S12_A0.135671.450
5_R11_H0.133531.427
20_L104_L0.133361.425
191_Y195_L0.130621.396
5_R8_S0.126081.348
34_P38_W0.12581.345
192_W196_I0.123551.321
112_F138_L0.122061.305
117_W121_Y0.121731.301
8_S59_D0.121621.300
112_F191_Y0.120641.289
109_S142_T0.11841.265
11_H52_S0.116771.248
53_L87_F0.115271.232
175_P179_L0.11511.230
112_F142_T0.11461.225
109_S114_N0.113461.213
110_T117_W0.111671.194
140_A196_I0.111631.193
34_P37_P0.111311.190
13_I111_P0.11131.190
12_A56_F0.111061.187
10_V84_L0.110511.181
185_L192_W0.109711.173
103_F151_F0.109031.165
95_F177_I0.108381.158
9_F12_A0.108151.156
159_Y164_P0.107341.147
11_H59_D0.107191.146
5_R114_N0.107061.144
110_T114_N0.106451.138
148_I190_I0.106441.138
125_Y129_S0.106181.135
8_S11_H0.105861.131
117_W196_I0.105671.129
141_V145_V0.104381.116
139_F192_W0.103991.111
19_G22_I0.103591.107
160_W164_P0.103391.105
140_A197_L0.10281.099
182_L185_L0.102611.097
63_M77_L0.102361.094
110_T113_L0.101721.087
10_V142_T0.10091.078
109_S146_F0.100451.074
9_F118_F0.099561.064
7_V107_E0.099241.061
185_L189_N0.099061.059
140_A143_F0.098911.057
7_V11_H0.098781.056
55_Y59_D0.098651.054
12_A107_E0.098621.054
152_P190_I0.098481.053
122_L125_Y0.098481.053
121_Y139_F0.098291.051
31_S35_D0.098191.049
193_F197_L0.097891.046
145_V180_V0.09781.045
12_A55_Y0.097791.045
127_K137_V0.097791.045
128_K131_L0.097541.043
29_L36_D0.097511.042
35_D38_W0.097131.038
71_G117_W0.097121.038
114_N118_F0.096791.035
144_F197_L0.096551.032
128_K132_Y0.096541.032
18_W172_W0.09631.029
47_F125_Y0.096091.027
56_F107_E0.09591.025
192_W195_L0.095631.022
158_V162_V0.095541.021
157_W161_D0.09521.018
83_T117_W0.095181.017
106_H182_L0.094951.015
148_I184_V0.094451.010
24_L132_Y0.094131.006
17_I38_W0.09371.001
142_T183_L0.09371.001
102_V110_T0.093641.001
144_F148_I0.093510.999
11_H143_F0.091980.983
114_N139_F0.091830.981
172_W176_W0.091740.981
164_P167_L0.091560.979
10_V145_V0.091490.978
99_G107_E0.091090.974
178_F182_L0.090950.972
114_N117_W0.090680.969
167_L180_V0.09050.967
156_Y193_F0.090270.965
173_P177_I0.090080.963
113_L116_R0.08980.960
25_N138_L0.089730.959
8_S106_H0.089510.957
60_L81_V0.08910.952
35_D78_L0.088780.949
18_W124_G0.088760.949
53_L64_L0.088370.945
74_W77_L0.088230.943
75_E191_Y0.088110.942
8_S189_N0.08790.939
103_F139_F0.087830.939
156_Y160_W0.08740.934
29_L57_L0.087380.934
7_V58_Y0.087250.933
188_L192_W0.087090.931
142_T146_F0.086960.929
129_S134_F0.086950.929
20_L149_V0.08690.929
79_H192_W0.08690.929
180_V191_Y0.08610.920
184_V193_F0.085580.915
143_F148_I0.085520.914
34_P134_F0.085230.911
14_V60_L0.085170.910
171_P174_V0.085130.910
50_A54_G0.085090.909
59_D107_E0.084880.907
18_W44_L0.084860.907
101_V105_L0.084590.904
65_L160_W0.084270.901
167_L190_I0.084250.900
25_N39_Y0.084110.899
5_R12_A0.083650.894
27_P30_W0.083220.889
82_V185_L0.083180.889
23_L81_V0.083030.887
99_G121_Y0.082580.883
154_L157_W0.082340.880
83_T185_L0.082260.879
107_E116_R0.082110.878
84_L100_I0.082110.878
58_Y80_H0.082050.877
140_A144_F0.081660.873
10_V78_L0.081630.872
76_M80_H0.081580.872
114_N192_W0.081310.869
17_I21_Y0.081280.869
28_E92_F0.081170.868
106_H114_N0.080590.861
75_E197_L0.08050.860
35_D48_Y0.080450.860
187_V191_Y0.08040.859
59_D62_V0.080340.859
58_Y63_M0.080230.858
90_S99_G0.079880.854
128_K133_R0.07970.852
68_R184_V0.079520.850
62_V103_F0.079490.850
142_T194_Y0.079460.849
168_W176_W0.07930.848
18_W51_F0.079280.847
52_S185_L0.079250.847
71_G121_Y0.079060.845
83_T178_F0.078990.844
21_Y27_P0.078790.842
88_Y197_L0.078760.842
31_S141_V0.078710.841
6_V118_F0.078650.841
110_T121_Y0.078360.838
18_W22_I0.07830.837
97_R134_F0.077970.833
10_V24_L0.07790.833
107_E117_W0.077720.831
29_L101_V0.077580.829
106_H156_Y0.077550.829
116_R132_Y0.07750.828
7_V86_L0.077310.826
160_W179_L0.077260.826
157_W162_V0.077220.825
120_K139_F0.077220.825
177_I180_V0.077040.823
114_N189_N0.076910.822
85_V184_V0.07690.822
67_Y70_R0.076870.822
99_G110_T0.076540.818
143_F151_F0.076510.818
119_L155_I0.076010.812
172_W190_I0.075990.812
5_R106_H0.075570.808
52_S59_D0.075150.803
164_P172_W0.075140.803
89_F93_Y0.075080.802
167_L184_V0.075070.802
14_V180_V0.0750.802
17_I20_L0.07490.801
47_F51_F0.074870.800
46_K56_F0.074840.800
88_Y138_L0.074840.800
167_L171_P0.074740.799
113_L144_F0.074690.798
99_G106_H0.074690.798
6_V54_G0.07450.796
57_L194_Y0.074230.793
106_H185_L0.074190.793
167_L187_V0.074140.792
10_V14_V0.074060.792
13_I138_L0.074030.791
17_I35_D0.073940.790
86_L117_W0.073820.789
83_T91_Y0.073780.789
128_K197_L0.073730.788
12_A15_S0.073120.782
130_S133_R0.07310.781
86_L121_Y0.073060.781
5_R143_F0.073050.781
67_Y101_V0.072850.779
56_F121_Y0.072640.776
148_I152_P0.072510.775
21_Y25_N0.072440.774
99_G185_L0.072410.774
26_D65_L0.072390.774
139_F143_F0.072210.772
155_I182_L0.0720.770
106_H151_F0.071880.768
60_L119_L0.071790.767
156_Y163_W0.071780.767
189_N195_L0.071730.767
102_V121_Y0.071720.767
80_H106_H0.071680.766
4_N7_V0.071640.766
20_L153_Y0.071610.765
14_V129_S0.071560.765
116_R133_R0.071450.764
62_V114_N0.071350.763
138_L164_P0.071230.761
143_F188_L0.071040.759
2_W118_F0.0710.759
13_I17_I0.07090.758
76_M79_H0.070710.756
90_S102_V0.070640.755
56_F114_N0.070640.755
4_N121_Y0.070610.755
184_V188_L0.070490.753
4_N69_K0.070470.753
87_F181_L0.070460.753
175_P178_F0.070460.753
55_Y69_K0.070440.753
20_L28_E0.070390.752
14_V57_L0.070250.751
124_G129_S0.070120.749
96_G102_V0.070040.749
9_F13_I0.069950.748
10_V17_I0.06990.747
59_D116_R0.069870.747
52_S107_E0.069810.746
178_F190_I0.069750.746
47_F197_L0.069720.745
78_L153_Y0.069660.745
125_Y128_K0.069630.744
67_Y110_T0.069610.744
82_V125_Y0.06940.742
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3izcN0.232310.962
2rkkA0.28280.90.963
1wn9A0.21720.80.964
2yf2A0.32830.70.966
2xovA0.36870.70.966
3omdA0.24750.70.967
1ywmA0.3030.60.967
2nr9A0.39390.60.967
4gh4D0.1010.60.967
4izzA0.3030.60.968
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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