GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Glyco_tran_WecB - Glycosyl transferase WecBTagACpsF family
Pfam: PF03808 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 172
Sequences: 1218
Seq/Len: 7.08
HH_delta: 0.922 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
50_R103_D0.513623.002
52_F79_G0.430852.518
118_I132_G0.414882.425
32_T35_D0.403362.358
52_F96_R0.398692.330
95_N99_A0.374072.186
58_E82_H0.359712.103
58_E62_E0.359032.099
117_W121_H0.34512.017
105_V127_A0.332291.942
81_H96_R0.329591.926
50_R76_R0.32311.889
149_K153_R0.322031.882
169_L172_R0.319551.868
65_A69_R0.308441.803
63_K143_K0.305571.786
135_G139_F0.300271.755
37_F106_F0.296161.731
118_I130_I0.294981.724
41_L68_L0.293051.713
150_W154_L0.284881.665
98_N126_P0.284251.661
146_R157_E0.279541.634
107_V118_I0.277041.619
34_S136_A0.272321.592
61_L80_Y0.27071.582
67_N71_R0.26811.567
2_A116_R0.252031.473
162_L172_R0.251261.469
51_I106_F0.250711.465
1_E5_S0.250361.463
94_I98_N0.247891.449
57_S84_Y0.247451.446
57_S60_V0.245531.435
39_D42_R0.245281.434
37_F140_L0.244221.427
53_L68_L0.244091.427
105_V130_I0.237331.387
61_L65_A0.234531.371
34_S139_F0.23441.370
30_R152_R0.233261.363
52_F97_I0.232121.357
67_N70_R0.228961.338
95_N98_N0.225271.317
32_T146_R0.225251.317
50_R78_V0.218591.278
63_K66_A0.216731.267
81_H84_Y0.215511.260
14_M17_V0.215321.259
37_F136_A0.215181.258
160_Y164_Q0.215111.257
91_E124_R0.214821.256
45_E75_L0.214481.254
106_F137_F0.213151.246
44_A104_I0.210051.228
90_E120_R0.208911.221
105_V121_H0.207961.216
110_G114_Q0.205151.199
90_E117_W0.205131.199
48_G76_R0.203851.192
133_V137_F0.200321.171
103_D128_G0.199421.166
91_E95_N0.198261.159
147_A157_E0.197951.157
35_D146_R0.19711.152
156_L159_L0.196851.151
7_D122_R0.195911.145
11_P17_V0.195841.145
10_L36_L0.194391.136
148_P160_Y0.193931.134
147_A152_R0.193171.129
37_F133_V0.191751.121
90_E94_I0.188291.101
35_D157_E0.186051.087
162_L170_W0.185411.084
98_N124_R0.185281.083
108_G137_F0.184221.077
145_K160_Y0.184111.076
59_E62_E0.183881.075
45_E74_G0.183431.072
43_R47_R0.183431.072
57_S143_K0.18231.066
3_L9_V0.18221.065
82_H85_F0.180561.055
65_A80_Y0.179821.051
151_M156_L0.17831.042
83_G135_G0.177631.038
57_S61_L0.176321.031
139_F147_A0.175681.027
44_A51_I0.174391.019
83_G139_F0.173531.014
62_E66_A0.17321.012
63_K67_N0.172911.011
49_K103_D0.172371.008
59_E80_Y0.172331.007
17_V27_L0.171231.001
14_M18_W0.170310.995
52_F81_H0.170250.995
40_L104_I0.169940.993
53_L137_F0.168530.985
66_A70_R0.166070.971
41_L106_F0.165970.970
151_M154_L0.164260.960
94_I121_H0.164030.959
11_P111_A0.163680.957
33_G146_R0.163530.956
33_G133_V0.16290.952
79_G100_S0.161190.942
56_G61_L0.160660.939
33_G132_G0.160340.937
165_E168_R0.158990.929
41_L51_I0.158960.929
34_S38_P0.158290.925
54_L97_I0.157840.923
52_F93_I0.157310.919
15_P83_G0.154530.903
34_S83_G0.153160.895
29_E152_R0.152880.894
34_S135_G0.151870.888
1_E4_N0.150110.877
20_A27_L0.149550.874
41_L75_L0.148550.868
105_V117_W0.148280.867
60_V138_D0.147850.864
32_T152_R0.147530.862
83_G113_K0.146890.859
50_R101_G0.146350.855
146_R152_R0.146050.854
43_R49_K0.144930.847
54_L81_H0.144760.846
5_S119_A0.143580.839
145_K164_Q0.14320.837
42_R46_Q0.143060.836
139_F146_R0.14260.833
78_V100_S0.142520.833
167_K172_R0.141060.824
147_A160_Y0.140260.820
159_L163_L0.140190.819
15_P19_A0.139680.816
14_M155_G0.139590.816
15_P82_H0.139040.813
75_L78_V0.138780.811
17_V30_R0.138590.810
106_F136_A0.138160.808
54_L117_W0.138160.808
167_K170_W0.138120.807
85_F93_I0.135720.793
105_V125_L0.13520.790
136_A139_F0.135080.790
54_L105_V0.134630.787
15_P138_D0.133860.782
44_A48_G0.133680.781
12_D161_R0.13360.781
81_H85_F0.13270.776
144_V165_E0.132660.775
48_G74_G0.132590.775
98_N125_L0.132490.774
106_F133_V0.132110.772
139_F160_Y0.131440.768
20_A25_R0.130660.764
64_A110_G0.130230.761
138_D143_K0.129590.757
6_A10_L0.129320.756
84_Y109_L0.129130.755
108_G133_V0.128880.753
66_A95_N0.128850.753
51_I75_L0.128760.753
32_T139_F0.128740.752
33_G147_A0.128690.752
89_E92_A0.128460.751
66_A145_K0.127670.746
122_R130_I0.127140.743
12_D134_G0.126940.742
58_E80_Y0.126720.741
162_L171_R0.126660.740
63_K141_A0.126090.737
17_V21_R0.125880.736
11_P137_F0.125870.736
31_V152_R0.125560.734
112_P115_E0.125140.731
121_H124_R0.124990.731
53_L64_A0.12490.730
20_A29_E0.124850.730
105_V118_I0.124760.729
151_M160_Y0.1240.725
82_H135_G0.123920.724
141_A160_Y0.123520.722
105_V128_G0.123420.721
35_D152_R0.123020.719
38_P71_R0.122620.717
159_L162_L0.122280.715
56_G60_V0.122090.714
12_D33_G0.122020.713
12_D110_G0.122010.713
88_E169_L0.121390.710
17_V32_T0.120940.707
134_G161_R0.120920.707
49_K102_P0.120780.706
24_G27_L0.120160.702
34_S37_F0.11960.699
149_K152_R0.119540.699
60_V141_A0.119330.697
44_A49_K0.118980.695
4_N9_V0.118710.694
47_R95_N0.118460.692
30_R34_S0.117980.690
106_F132_G0.117660.688
133_V136_A0.117510.687
18_W155_G0.117440.686
26_P29_E0.117390.686
37_F41_L0.117210.685
64_A136_A0.116850.683
1_E95_N0.116820.683
33_G139_F0.116820.683
5_S123_Q0.116670.682
15_P84_Y0.116640.682
20_A26_P0.115860.677
91_E98_N0.115630.676
122_R129_V0.115570.676
37_F111_A0.115150.673
15_P18_W0.115060.673
81_H93_I0.114540.669
114_Q162_L0.114160.667
138_D168_R0.113570.664
34_S165_E0.113140.661
62_E65_A0.113110.661
42_R45_E0.112930.660
11_P15_P0.112610.658
86_D89_E0.112550.658
150_W153_R0.112120.655
109_L114_Q0.111390.651
42_R72_Y0.111230.650
54_L121_H0.110850.648
114_Q132_G0.109980.643
32_T136_A0.109410.640
163_L167_K0.109210.638
54_L85_F0.108920.637
6_A110_G0.108730.636
50_R100_S0.108030.631
145_K151_M0.107990.631
60_V63_K0.107980.631
17_V20_A0.107610.629
145_K154_L0.10750.628
64_A137_F0.107210.627
2_A119_A0.107030.626
33_G136_A0.107010.625
33_G36_L0.106340.622
145_K153_R0.106260.621
31_V36_L0.106140.620
41_L45_E0.105730.618
30_R139_F0.105580.617
69_R99_A0.105360.616
1_E24_G0.105130.614
50_R128_G0.105080.614
41_L44_A0.105050.614
162_L168_R0.104950.613
32_T109_L0.104910.613
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2ynmC0.8663830.922
2zayA0.715182.60.923
3h5lA0.9651800.925
1qkkA0.680278.30.926
4f11A0.9826770.926
1a2oA0.68676.30.927
3cnbA0.709374.60.928
3hdgA0.703574.50.928
3lopA0.930273.70.928
4f06A0.970973.50.928
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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