GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
FSH1 - Serine hydrolase (FSH1)
Pfam: PF03959 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0028
Length: 212
Sequences: 38637
Seq/Len: 182.25
HH_delta: 0.198 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
105_G137_F3.640584.558
192_R196_H2.345642.936
120_L138_A2.20752.764
106_V116_A2.098592.627
142_S172_D1.815542.273
6_R37_E1.785992.236
140_F143_G1.626082.036
92_Y96_Y1.545871.935
6_R39_V1.468171.838
17_A42_D1.405751.760
164_T187_F1.379761.727
170_E195_E1.354091.695
12_G110_S1.345511.684
184_A191_A1.34241.681
191_A196_H1.323731.657
9_C107_L1.294821.621
168_I180_S1.287091.611
118_L122_L1.275331.597
177_P181_E1.268381.588
117_A140_F1.261341.579
118_L121_A1.248211.563
13_Y111_Q1.229791.540
7_I36_F1.21261.518
119_L123_Q1.210271.515
170_E196_H1.205221.509
96_Y99_E1.19861.501
170_E197_D1.195691.497
168_I177_P1.182161.480
107_L141_I1.171771.467
113_A143_G1.157281.449
182_A186_M1.119041.401
105_G136_K1.104181.382
105_G139_V1.103861.382
5_P105_G1.101871.379
138_A164_T1.098961.376
181_E195_E1.089331.364
15_Q19_I1.086041.360
87_D122_L1.08411.357
156_D159_K1.067951.337
7_I107_L1.067161.336
137_F163_P1.067151.336
91_D95_D1.064651.333
116_A138_A1.064181.332
10_L43_G1.061361.329
44_P92_Y1.057561.324
108_G116_A1.05551.321
92_Y95_D1.050451.315
181_E185_E1.041341.304
14_G110_S1.027811.287
5_P103_F1.015111.271
87_D91_D1.00581.259
10_L41_V0.996681.248
10_L116_A0.986031.234
139_V165_L0.974461.220
170_E177_P0.973261.218
10_L106_V0.970281.215
11_H43_G0.961151.203
5_P36_F0.956951.198
181_E184_A0.946681.185
182_A185_E0.944821.183
89_S92_Y0.931781.166
137_F165_L0.930921.165
94_R119_L0.929891.164
9_C20_F0.909511.139
88_E91_D0.905561.134
103_F136_K0.89951.126
9_C38_F0.898581.125
44_P85_G0.895451.121
85_G88_E0.890841.115
36_F105_G0.88561.109
165_L194_I0.877491.099
43_G115_L0.876041.097
184_A193_V0.869651.089
107_L139_V0.862031.079
110_S200_H0.856551.072
191_A195_E0.852421.067
109_F142_S0.834091.044
43_G111_Q0.824031.032
177_P195_E0.821541.028
140_F166_H0.8211.028
6_R104_D0.813251.018
157_E160_I0.790670.990
198_G202_V0.789810.989
97_I104_D0.789270.988
108_G112_G0.782930.980
184_A188_D0.748010.936
26_A30_A0.746340.934
165_L192_R0.746180.934
10_L86_L0.743440.931
17_A40_F0.741710.929
179_R182_A0.738150.924
23_Q26_A0.737830.924
44_P89_S0.736630.922
106_V135_F0.735750.921
168_I175_V0.734770.920
168_I195_E0.731690.916
117_A183_L0.729160.913
121_A156_D0.724680.907
97_I102_P0.715930.896
24_T28_R0.715160.895
109_F201_H0.713780.894
24_T40_F0.709520.888
11_H41_V0.701110.878
100_N103_F0.700260.877
180_S184_A0.690090.864
7_I38_F0.688440.862
168_I193_V0.686680.860
90_L135_F0.685290.858
85_G89_S0.685050.858
113_A140_F0.683710.856
109_F141_I0.679120.850
94_R123_Q0.678160.849
8_L104_D0.668080.836
139_V167_V0.666230.834
171_N197_D0.661170.828
111_Q115_L0.652620.817
96_Y100_N0.645460.808
26_A29_K0.63630.797
106_V119_L0.636280.797
90_L94_R0.634720.795
25_S29_K0.631280.790
166_H180_S0.630950.790
108_G113_A0.629790.788
142_S169_G0.627930.786
181_E193_V0.62520.783
10_L115_L0.62170.778
191_A194_I0.62010.776
167_V196_H0.618380.774
114_A144_F0.616330.772
191_A197_D0.615860.771
22_Q25_S0.615250.770
158_P186_M0.614970.770
14_G111_Q0.612410.767
166_H184_A0.611280.765
9_C40_F0.610020.764
6_R36_F0.60840.762
19_I203_P0.599980.751
172_D175_V0.594690.744
91_D122_L0.594190.744
111_Q114_A0.594040.744
144_F175_V0.592020.741
187_F191_A0.591440.740
88_E92_Y0.5850.732
7_I105_G0.584810.732
138_A162_I0.584510.732
91_D123_Q0.58450.732
37_E40_F0.581870.728
152_Q155_Y0.581360.728
188_D191_A0.578080.724
178_E181_E0.577240.723
91_D94_R0.576680.722
118_L156_D0.572170.716
114_A118_L0.570820.715
94_R98_E0.569390.713
97_I100_N0.568690.712
121_A159_K0.568620.712
5_P136_K0.567250.710
20_F109_F0.564830.707
21_R25_S0.561930.703
18_E21_R0.556960.697
98_E102_P0.553560.693
20_F23_Q0.553340.693
8_L106_V0.547130.685
160_I187_F0.546070.684
90_L119_L0.545550.683
116_A120_L0.544040.681
95_D99_E0.543610.681
112_G116_A0.539120.675
166_H183_L0.537510.673
171_N198_G0.537130.672
35_D38_F0.535860.671
141_I167_V0.535790.671
25_S28_R0.534250.669
11_H16_N0.533980.668
19_I109_F0.532140.666
142_S202_V0.531450.665
169_G202_V0.53060.664
89_S96_Y0.525120.657
120_L162_I0.522440.654
6_R105_G0.520030.651
20_F24_T0.519720.651
166_H187_F0.518820.649
176_P179_R0.518570.649
104_D136_K0.515970.646
9_C109_F0.51440.644
28_R38_F0.51280.642
8_L39_V0.505870.633
39_V93_L0.505580.633
37_E102_P0.503710.631
38_F41_V0.50320.630
109_F203_P0.499010.625
11_H40_F0.498740.624
104_D135_F0.497310.623
183_L187_F0.494290.619
160_I163_P0.490080.614
171_N199_G0.487070.610
99_E102_P0.485350.608
97_I101_G0.482830.604
12_G109_F0.482560.604
25_S30_A0.481760.603
94_R97_I0.476860.597
135_F138_A0.473110.592
116_A140_F0.472980.592
143_G166_H0.471640.590
146_P149_P0.471190.590
124_Q161_S0.466730.584
178_E182_A0.466640.584
106_V138_A0.464620.582
122_L156_D0.464250.581
142_S201_H0.463920.581
93_L97_I0.461070.577
89_S94_R0.459310.575
6_R102_P0.458840.574
122_L125_R0.456470.571
15_Q201_H0.454950.570
114_A117_A0.452980.567
84_E88_E0.44980.563
41_V89_S0.446630.559
10_L119_L0.44520.557
174_V199_G0.443590.555
85_G92_Y0.443430.555
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3v48A0.81699.80.198
3dqzA0.825599.80.211
3oosA0.820899.80.215
3i28A0.825599.80.217
1xklA0.81699.80.222
3u1tA0.81699.80.229
3hjuA0.839699.80.229
3styA0.81699.80.23
3fobA0.81699.80.231
4fblA0.825599.80.233

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