GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF360 - Membrane protein of unknown function
Pfam: PF04020 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 108
Sequences: 941
Seq/Len: 8.71
HH_delta: 0.937 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
59_T67_G0.546093.038
75_L97_G0.391522.178
75_L101_L0.381772.124
18_A101_L0.36172.012
53_L56_L0.353361.966
16_L33_A0.345791.924
43_L74_M0.341531.900
18_A100_V0.339431.888
22_L93_S0.329021.830
43_L47_L0.326281.815
15_L36_A0.312551.739
73_L76_Y0.306971.708
68_L95_F0.305241.698
72_A95_F0.304521.694
43_L78_A0.283271.576
91_F95_F0.269641.500
52_V67_G0.261151.453
75_L88_V0.259761.445
104_V108_V0.254561.416
91_F94_A0.249451.388
90_G93_S0.243921.357
12_A34_L0.23661.316
14_A108_V0.23641.315
22_L100_V0.234461.304
30_F33_A0.234171.303
100_V104_V0.22731.265
44_N71_N0.225541.255
15_L97_G0.224411.248
66_F69_V0.222851.240
56_L59_T0.217011.207
97_G101_L0.216971.207
79_S88_V0.216921.207
72_A75_L0.208741.161
52_V55_T0.208321.159
55_T67_G0.207091.152
93_S97_G0.206941.151
32_T36_A0.204181.136
82_V86_F0.203931.135
39_V78_A0.202381.126
18_A76_Y0.200451.115
25_I97_G0.197631.099
82_V85_G0.197611.099
55_T66_F0.195381.087
48_R102_S0.191491.065
49_P54_L0.191481.065
65_L69_V0.191.057
72_A98_A0.188731.050
16_L107_I0.185571.032
16_L27_V0.185571.032
95_F98_A0.185431.032
50_I53_L0.184781.028
36_A86_F0.184461.026
40_L78_A0.181261.008
27_V33_A0.180351.003
68_L71_N0.180251.003
48_R52_V0.179560.999
22_L97_G0.179420.998
4_F38_L0.178740.994
35_V96_L0.177770.989
94_A98_A0.177720.989
34_L38_L0.175990.979
39_V82_V0.173810.967
2_M5_L0.169350.942
96_L99_I0.168730.939
38_L42_L0.168360.937
41_G44_N0.167470.932
16_L20_Y0.165530.921
59_T66_F0.165020.918
5_L9_I0.164070.913
55_T59_T0.162640.905
43_L106_S0.162360.903
73_L77_L0.162030.901
17_V20_Y0.161460.898
50_I81_L0.161220.897
36_A79_S0.15950.887
13_L60_I0.158820.884
10_V105_N0.15870.883
92_W96_L0.158160.880
45_A72_A0.158130.880
36_A78_A0.157930.879
13_L23_P0.157840.878
25_I79_S0.157710.877
41_G105_N0.155950.868
11_N24_G0.155670.866
48_R67_G0.154930.862
25_I101_L0.154670.860
40_L66_F0.154290.858
8_W42_L0.151940.845
79_S87_H0.151120.841
62_T66_F0.149830.834
8_W14_A0.148020.823
51_L80_W0.147780.822
14_A18_A0.145510.810
101_L104_V0.145380.809
11_N75_L0.144890.806
12_A30_F0.144530.804
51_L74_M0.144510.804
60_I69_V0.144130.802
48_R66_F0.144020.801
32_T86_F0.14370.799
27_V74_M0.142350.792
13_L87_H0.141810.789
14_A104_V0.141720.788
40_L63_L0.141560.788
13_L17_V0.140210.780
73_L108_V0.140110.779
56_L60_I0.139970.779
49_P62_T0.139830.778
4_F81_L0.139340.775
62_T71_N0.139120.774
52_V56_L0.138530.771
18_A34_L0.137980.768
15_L101_L0.137680.766
77_L101_L0.137230.763
89_D93_S0.136190.758
3_R26_E0.136150.757
32_T82_V0.136140.757
57_P62_T0.134910.751
2_M10_V0.13480.750
81_L103_I0.134570.749
39_V102_S0.134120.746
47_L51_L0.133630.743
32_T37_A0.132960.740
7_R104_V0.132480.737
29_S32_T0.131550.732
15_L78_A0.130730.727
77_L104_V0.130030.723
42_L46_L0.129490.720
11_N15_L0.129080.718
6_L16_L0.128930.717
77_L80_W0.128910.717
52_V70_I0.128290.714
29_S79_S0.128230.713
88_V99_I0.12790.712
26_E89_D0.127820.711
25_I75_L0.12740.709
26_E93_S0.127080.707
31_G38_L0.126310.703
12_A72_A0.126060.701
57_P71_N0.126010.701
97_G106_S0.125470.698
10_V63_L0.125150.696
58_I66_F0.124980.695
8_W11_N0.124690.694
41_G45_A0.124020.690
50_I69_V0.123730.688
12_A63_L0.123420.687
33_A86_F0.123180.685
34_L82_V0.122520.682
2_M50_I0.122220.680
4_F82_V0.12210.679
31_G103_I0.1220.679
64_G71_N0.121940.678
47_L67_G0.121840.678
98_A102_S0.121430.676
8_W34_L0.121220.674
8_W108_V0.120770.672
53_L57_P0.120730.672
76_Y80_W0.120710.672
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2k3cA0.30561.30.937
4humA0.990710.942
1rh5A0.86110.90.944
2wwbA0.87040.80.945
3dh4A0.92590.80.945
2ls2A0.24070.80.945
4he8H0.82410.70.947
3w4tA0.95370.70.948
2kv5A0.19440.60.948
2m20A0.20370.60.948
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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