GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF378 - Domain of unknown function (DUF378)
Pfam: PF04070 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 62
Sequences: 282
Seq/Len: 4.55
HH_delta: 0.897 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
16_A53_G0.915224.954
24_L47_I0.481822.608
28_N31_A0.481362.606
5_D62_R0.346331.875
12_V16_A0.317751.720
3_I7_I0.294761.595
12_V56_C0.294731.595
10_I60_L0.283981.537
29_L46_Y0.254031.375
19_W30_V0.253391.372
4_L48_L0.251561.362
31_A46_Y0.245181.327
6_K60_L0.230121.246
8_A56_C0.229811.244
48_L52_A0.228321.236
39_S42_S0.226031.223
52_A56_C0.225421.220
56_C59_L0.225281.219
17_L51_L0.224991.218
30_V45_I0.220741.195
32_A49_V0.21261.151
6_K61_F0.207551.123
32_A41_L0.201171.089
27_F32_A0.200781.087
5_D8_A0.191611.037
21_L29_L0.184220.997
58_S62_R0.184090.996
2_K6_K0.181480.982
44_I54_L0.181140.980
50_G54_L0.179930.974
20_G27_F0.179770.973
14_I62_R0.178580.967
28_N42_S0.17850.966
52_A59_L0.178160.964
31_A37_S0.174960.947
29_L49_V0.170690.924
51_L55_Y0.16760.907
21_L27_F0.167110.905
5_D59_L0.163490.885
26_N38_A0.16070.870
7_I17_L0.156520.847
45_I49_V0.155840.844
13_I57_I0.15570.843
17_L22_I0.151690.821
22_I28_N0.151570.820
34_F42_S0.150560.815
50_G53_G0.149720.810
2_K60_L0.149570.810
7_I55_Y0.147990.801
23_G50_G0.147930.801
8_A52_A0.147780.800
18_N21_L0.147520.799
40_W52_A0.146360.792
24_L56_C0.146190.791
5_D55_Y0.145610.788
11_L48_L0.143660.778
5_D56_C0.14250.771
59_L62_R0.141950.768
26_N57_I0.141660.767
26_N61_F0.140010.758
36_G49_V0.139570.755
6_K20_G0.139070.753
3_I54_L0.139050.753
34_F41_L0.136690.740
6_K57_I0.135380.733
15_G19_W0.134890.730
34_F43_R0.134140.726
12_V53_G0.133630.723
30_V33_L0.133520.723
18_N30_V0.133140.721
15_G36_G0.132630.718
4_L55_Y0.132510.717
6_K51_L0.130930.709
20_G43_R0.128580.696
26_N60_L0.126770.686
15_G23_G0.1240.671
38_A56_C0.12290.665
9_L42_S0.121970.660
4_L7_I0.121110.656
20_G38_A0.121070.655
32_A43_R0.119360.646
5_D9_L0.118910.644
22_I47_I0.118650.642
23_G47_I0.117540.636
11_L30_V0.11740.635
22_I30_V0.117030.633
26_N56_C0.116710.632
4_L17_L0.115550.625
36_G42_S0.11490.622
10_I16_A0.114190.618
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
4ev6A0.8717.60.897
4i0uA0.88714.90.905
4he8J0.80654.40.907
2iubA0.83873.60.91
2l0lA0.41941.60.924
2wdqC0.95161.50.926
3rfrC0.95161.50.926
2qtsA0.61291.40.926
1yewC0.95161.30.928
3ripA0.3711.20.93
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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