GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
FA_hydroxylase - Fatty acid hydroxylase superfamily
Pfam: PF04116 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 114
Sequences: 2825
Seq/Len: 24.78
HH_delta: 0.925 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
13_Y17_R0.895774.629
10_F14_W0.61863.197
14_W17_R0.596153.081
98_R102_L0.402932.082
104_V108_H0.32981.704
18_L22_I0.326851.689
88_H109_H0.317291.640
29_H33_H0.308871.596
93_H96_P0.306481.584
24_F27_R0.30571.580
15_M19_L0.297071.535
28_I49_L0.291751.508
98_R101_Y0.284691.471
12_E15_M0.284071.468
109_H113_H0.279581.445
109_H112_H0.275961.426
18_L25_L0.274511.419
4_G76_G0.272681.409
84_Y87_I0.269741.394
29_H32_H0.264551.367
31_V47_H0.263181.360
22_I25_L0.261221.350
16_H20_H0.259941.343
44_F81_Y0.25451.315
47_H50_E0.24871.285
8_W80_F0.237131.225
6_L10_F0.235231.216
35_P42_S0.234321.211
4_G68_F0.233631.207
46_F51_A0.229561.186
54_L58_P0.22031.138
94_R97_P0.217581.124
43_A84_Y0.213691.104
83_W87_I0.213451.103
107_R111_L0.210451.088
8_W76_G0.209151.081
38_P45_R0.208771.079
94_R98_R0.208091.075
51_A55_A0.207171.071
54_L57_L0.207091.070
69_H72_A0.206331.066
8_W12_E0.206321.066
99_L102_L0.205521.062
103_F106_P0.204991.059
11_W15_M0.201451.041
20_H33_H0.19971.032
79_L83_W0.196761.017
32_H88_H0.196641.016
43_A46_F0.195991.013
97_P101_Y0.195981.013
46_F84_Y0.193771.001
59_L64_L0.193170.998
101_Y105_T0.19280.996
41_L45_R0.192250.993
12_E46_F0.19180.991
82_L86_F0.189430.979
81_Y84_Y0.187120.967
3_L7_L0.186030.961
76_G80_F0.185780.960
40_P43_A0.185230.957
73_F81_Y0.183450.948
106_P110_D0.183270.947
37_N42_S0.182270.942
64_L73_F0.181650.939
8_W81_Y0.18160.938
99_L103_F0.177750.919
72_A75_L0.177460.917
95_F98_R0.176610.913
105_T108_H0.176190.910
63_L73_F0.175750.908
9_D12_E0.175450.907
93_H97_P0.174260.901
78_A82_L0.173940.899
11_W62_P0.173860.898
46_F81_Y0.17270.892
97_P102_L0.171940.889
34_S45_R0.17010.879
100_R104_V0.169670.877
15_M18_L0.169540.876
9_D104_V0.168980.873
63_L67_P0.16840.870
30_K37_N0.168060.868
13_Y16_H0.167640.866
28_I47_H0.167530.866
11_W77_I0.167110.864
16_H29_H0.166120.858
37_N40_P0.165880.857
88_H113_H0.165390.855
48_P55_A0.164780.852
32_H109_H0.163960.847
44_F48_P0.162870.842
7_L66_L0.162220.838
51_A58_P0.162120.838
83_W86_F0.162010.837
77_I80_F0.1610.832
39_T42_S0.160940.832
26_W35_P0.160350.829
37_N75_L0.159810.826
19_L53_L0.158960.821
4_G73_F0.158870.821
76_G84_Y0.158550.819
49_L53_L0.157650.815
7_L10_F0.157460.814
88_H112_H0.157450.814
96_P99_L0.156180.807
111_L114_S0.154860.800
90_G110_D0.154730.800
2_L6_L0.15430.797
63_L66_L0.154290.797
31_V34_S0.153530.793
38_P90_G0.153340.792
22_I26_W0.153020.791
20_H29_H0.152910.790
19_L84_Y0.151810.784
72_A76_G0.151540.783
7_L53_L0.150890.780
12_E87_I0.150880.780
41_L111_L0.150640.778
107_R110_D0.150020.775
40_P87_I0.149910.775
32_H113_H0.149750.774
67_P73_F0.149210.771
53_L56_L0.149160.771
28_I50_E0.148230.766
87_I104_V0.147940.764
40_P44_F0.147770.764
37_N91_Y0.147480.762
8_W19_L0.146980.760
37_N74_L0.146970.759
40_P45_R0.146880.759
44_F51_A0.146880.759
51_A76_G0.146530.757
30_K46_F0.146430.757
4_G8_W0.146260.756
78_A81_Y0.146130.755
41_L44_F0.145180.750
71_L75_L0.145170.750
64_L70_A0.144960.749
106_P111_L0.143460.741
15_M53_L0.142940.739
35_P45_R0.142880.738
11_W57_L0.14250.736
35_P107_R0.142320.735
32_H112_H0.141010.729
80_F84_Y0.140440.726
23_P52_L0.140140.724
46_F50_E0.139240.720
25_L41_L0.138670.717
48_P72_A0.138330.715
49_L56_L0.138330.715
48_P51_A0.138310.715
16_H33_H0.138250.714
77_I81_Y0.138210.714
53_L59_L0.137030.708
39_T45_R0.136730.707
12_E57_L0.136440.705
71_L78_A0.136070.703
44_F54_L0.135970.703
50_E87_I0.13580.702
23_P94_R0.135540.700
23_P28_I0.135470.700
38_P43_A0.135210.699
4_G80_F0.135040.698
96_P100_R0.13490.697
3_L64_L0.134840.697
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2xq2A0.90352.20.925
1kf6D0.66670.90.939
2hzsI0.23680.70.945
3ts7A0.35960.60.947
2l8sA0.47370.50.947
3arcL0.14040.50.947
3nk4C0.26320.50.949
2zjsE0.17540.50.95
4dhdA0.35960.50.95
4f62A0.35960.40.952
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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