GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
GtrA - GtrA-like protein
Pfam: PF04138 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 117
Sequences: 2351
Seq/Len: 20.09
HH_delta: 0.892 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
112_S116_V0.777762.779
42_F46_L0.777692.779
9_G43_N0.706162.523
16_V38_V0.698632.496
48_R63_Q0.616472.203
12_V42_F0.561932.008
17_F35_A0.551331.970
70_V111_L0.540651.932
13_D97_K0.526721.882
8_I42_F0.525231.877
41_I64_F0.520091.858
47_N51_T0.504691.803
48_R117_F0.501271.791
32_N97_K0.488281.745
100_A104_V0.485551.735
66_R115_W0.482191.723
5_V46_L0.464721.661
20_L34_I0.434961.554
44_F63_Q0.42691.525
33_V75_L0.423631.514
16_V20_L0.420881.504
21_L93_Y0.419071.497
17_F93_Y0.417281.491
32_N79_T0.415451.485
43_N47_N0.40681.454
5_V51_T0.398171.423
36_F75_L0.392241.402
13_D32_N0.389591.392
52_F113_K0.380961.361
37_I68_F0.378171.351
13_D35_A0.376071.344
40_I71_Y0.372861.332
67_F71_Y0.362051.294
32_N82_L0.355781.271
85_L96_A0.350051.251
1_R50_F0.346141.237
14_F18_Y0.338591.210
17_F97_K0.336921.204
6_G105_F0.334011.194
9_G42_F0.324931.161
36_F40_I0.324071.158
81_I85_L0.323861.157
3_A7_V0.321321.148
29_L79_T0.318851.139
22_E93_Y0.317191.133
64_F68_F0.317061.133
43_N67_F0.31591.129
13_D78_N0.314941.125
62_R66_R0.312691.117
7_V11_L0.311551.113
81_I100_A0.310981.111
84_L88_W0.308291.102
29_L83_W0.308231.101
65_L69_V0.307461.099
110_L114_F0.307071.097
111_L115_W0.304911.090
76_L80_L0.299461.070
44_F48_R0.298531.067
43_N71_Y0.298121.065
109_F113_K0.292021.043
13_D39_A0.282781.010
10_T13_D0.279821.000
9_G13_D0.27810.994
74_G108_N0.277750.993
61_W65_L0.270050.965
54_S63_Q0.266880.954
75_L79_T0.266540.952
41_I45_I0.265760.950
67_F75_L0.265230.948
70_V116_V0.265110.947
14_F97_K0.264540.945
3_A105_F0.261750.935
26_L30_L0.261090.933
19_L23_F0.257470.920
36_F101_I0.255430.913
17_F82_L0.255150.912
28_Y86_V0.251420.898
69_V73_L0.250570.895
47_N112_S0.249650.892
2_F5_V0.24870.889
2_F71_Y0.247610.885
10_T43_N0.246950.882
63_Q67_F0.244770.875
78_N82_L0.242280.866
1_R5_V0.242180.865
40_I68_F0.240640.860
18_Y22_E0.238190.851
66_R116_V0.236590.845
108_N112_S0.235940.843
10_T101_I0.235320.841
74_G104_V0.233860.836
107_V111_L0.229260.819
33_V79_T0.228670.817
85_L99_I0.228380.816
2_F108_N0.227030.811
35_A39_A0.226110.808
2_F6_G0.225730.807
22_E26_L0.224570.802
47_N105_F0.220270.787
27_N30_L0.218920.782
78_N104_V0.218230.780
6_G51_T0.21670.774
71_Y74_G0.21630.773
8_I46_L0.21480.768
78_N97_K0.214670.767
77_L107_V0.21390.764
29_L87_D0.213640.763
14_F101_I0.212920.761
12_V39_A0.212660.760
74_G107_V0.212020.758
98_L102_G0.209280.748
13_D28_Y0.208870.746
102_G106_V0.208160.744
36_F39_A0.208140.744
4_L8_I0.207550.742
9_G40_I0.207520.742
9_G112_S0.202940.725
19_L24_L0.201790.721
48_R56_G0.199590.713
48_R54_S0.198610.710
97_K101_I0.198230.708
17_F21_L0.196860.703
82_L97_K0.195320.698
79_T82_L0.194710.696
52_F114_F0.193560.692
36_F108_N0.193210.690
61_W64_F0.191580.685
45_I49_R0.191050.683
10_T105_F0.189580.677
106_V110_L0.188110.672
28_Y87_D0.18630.666
40_I47_N0.18530.662
113_K117_F0.184550.659
71_Y112_S0.184440.659
5_V50_F0.184240.658
96_A100_A0.184160.658
9_G46_L0.183180.655
21_L31_A0.182630.653
83_W93_Y0.182290.651
92_P95_I0.182120.651
71_Y78_N0.182020.650
20_L26_L0.181690.649
2_F82_L0.181680.649
98_L101_I0.18150.649
12_V35_A0.180980.647
10_T98_L0.180820.646
8_I11_L0.18020.644
30_L33_V0.179860.643
7_V10_T0.179810.643
45_I68_F0.177970.636
20_L24_L0.177690.635
38_V42_F0.177190.633
9_G47_N0.176990.632
26_L31_A0.176540.631
32_N43_N0.176450.631
1_R47_N0.175980.629
10_T44_F0.175530.627
33_V37_I0.174680.624
104_V108_N0.173860.621
75_L82_L0.172770.617
19_L99_I0.172510.616
61_W115_W0.172330.616
51_T112_S0.171370.612
91_I96_A0.171140.612
78_N101_I0.170720.610
70_V79_T0.169770.607
77_L104_V0.169530.606
83_W87_D0.168980.604
5_V8_I0.167030.597
34_I91_I0.165430.591
85_L89_L0.164050.586
75_L104_V0.163470.584
67_F112_S0.163020.583
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
4humA0.5556130.892
3mktA0.5478.30.901
3aqpA0.96587.20.903
3w4tA0.5477.10.903
4il3A0.99156.40.905
4av3A0.8123.20.917
3qnqA0.982930.919
3mp7B0.1882.80.92
2wwbB0.19661.60.928
3iyzA0.94871.50.93
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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