GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF418 - Protein of unknown function (DUF418)
Pfam: PF04235 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0316
Length: 163
Sequences: 762
Seq/Len: 4.67
HH_delta: 0.941 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
99_I152_L0.561065.467
97_N140_S0.490354.778
120_L128_I0.256892.503
149_R154_W0.242292.361
93_M143_W0.238372.323
107_L114_L0.230722.248
106_T112_Y0.228572.227
9_R12_E0.210332.049
154_W158_R0.200811.957
96_T100_L0.196981.919
142_L146_R0.19691.919
104_I132_I0.195171.902
86_P89_A0.183431.787
142_L147_F0.182311.776
93_M144_L0.173411.690
97_N136_Q0.169621.653
5_G8_E0.162831.587
89_A141_Y0.15511.511
105_G132_I0.154781.508
106_T110_Y0.150011.462
96_T139_F0.149391.456
141_Y145_R0.148481.447
108_L116_L0.147191.434
90_V97_N0.142451.388
28_G32_A0.137621.341
15_K19_R0.136971.335
138_L142_L0.13691.334
92_R144_L0.136771.333
87_L137_L0.135491.320
140_S144_L0.131121.278
22_L26_A0.127951.247
149_R158_R0.127381.241
101_Q136_Q0.125051.218
10_P13_H0.124991.218
26_A30_P0.124351.212
97_N144_L0.121841.187
21_L70_L0.121461.183
121_S124_Q0.120771.177
83_L131_G0.119621.166
90_V137_L0.11821.152
70_L73_L0.117231.142
60_G67_Y0.116721.137
95_L152_L0.11461.117
106_T113_G0.114581.116
107_L112_Y0.112981.101
135_V142_L0.112821.099
143_W156_W0.112321.094
142_L145_R0.111751.089
69_A73_L0.110451.076
127_L131_G0.110021.072
110_Y115_G0.109911.071
94_A156_W0.109871.071
66_G69_A0.109521.067
147_F156_W0.107811.050
5_G9_R0.10771.049
21_L69_A0.107321.046
28_G36_A0.10721.045
143_W147_F0.107161.044
7_F87_L0.106911.042
92_R152_L0.106761.040
89_A95_L0.106131.034
132_I135_V0.104971.023
137_L141_Y0.104841.022
94_A97_N0.10431.016
116_L120_L0.102921.003
1_A6_F0.10240.998
97_N143_W0.102230.996
102_S105_G0.101740.991
89_A158_R0.101480.989
149_R161_Y0.099840.973
24_G69_A0.098750.962
62_L66_G0.098640.961
93_M156_W0.096910.944
92_R160_T0.09680.943
32_A36_A0.096770.943
149_R157_R0.096260.938
94_A140_S0.095950.935
13_H99_I0.095880.934
119_H134_V0.095040.926
104_I119_H0.09480.924
122_P139_F0.094280.919
21_L66_G0.093950.915
111_G115_G0.093670.913
13_H17_L0.093670.913
156_W160_T0.093610.912
28_G66_G0.093490.911
103_I152_L0.093190.908
55_L58_L0.093030.906
144_L147_F0.092770.904
13_H16_L0.092280.899
60_G161_Y0.092020.897
20_L24_G0.091960.896
26_A142_L0.091590.892
50_H53_S0.091540.892
77_K80_R0.09130.890
28_G59_G0.09120.889
28_G67_Y0.091120.888
71_L114_L0.090940.886
111_G114_L0.090290.880
25_L67_Y0.090190.879
93_M108_L0.090130.878
67_Y71_L0.090110.878
84_L87_L0.089890.876
61_P96_T0.089830.875
9_R13_H0.089510.872
136_Q156_W0.089240.870
28_G113_G0.089140.869
70_L134_V0.088970.867
55_L69_A0.088870.866
149_R156_W0.08850.862
120_L124_Q0.08850.862
71_L84_L0.088470.862
104_I160_T0.088330.861
29_L96_T0.08830.860
29_L59_G0.087610.854
92_R126_L0.087380.851
59_G63_L0.087180.849
23_I27_V0.086960.847
7_F66_G0.086710.845
104_I108_L0.086570.843
70_L74_L0.086310.841
93_M136_Q0.086130.839
82_R86_P0.086080.839
60_G73_L0.085790.836
68_V118_G0.085630.834
102_S136_Q0.085530.833
2_G129_A0.084620.824
95_L156_W0.084520.824
35_S51_L0.084460.823
140_S154_W0.084280.821
55_L160_T0.084180.820
36_A60_G0.08410.819
110_Y113_G0.083870.817
32_A94_A0.083720.816
51_L54_V0.083340.812
54_V121_S0.083230.811
108_L128_I0.083220.811
106_T111_G0.083180.810
109_F117_F0.083160.810
103_I119_H0.083150.810
71_L135_V0.082910.808
44_P83_L0.082860.807
1_A68_V0.082830.807
9_R16_L0.082730.806
17_L73_L0.082270.802
100_L106_T0.08170.796
21_L34_L0.081430.793
89_A93_M0.081180.791
122_P125_S0.081150.791
24_G81_Q0.080810.787
35_S53_S0.08060.785
72_I95_L0.080550.785
5_G56_Y0.079950.779
105_G117_F0.07980.778
33_L78_R0.079790.777
58_L131_G0.079570.775
15_K131_G0.079530.775
51_L96_T0.079430.774
54_V62_L0.079360.773
35_S60_G0.079230.772
30_P126_L0.079220.772
125_S129_A0.078960.769
29_L134_V0.078910.769
26_A141_Y0.078770.767
102_S133_W0.078730.767
62_L67_Y0.078730.767
30_P34_L0.078730.767
94_A125_S0.078620.766
127_L134_V0.07860.766
97_N102_S0.078570.766
27_V155_L0.078510.765
64_A146_R0.078390.764
109_F112_Y0.078340.763
101_Q128_I0.078210.762
66_G70_L0.078050.760
16_L65_L0.077990.760
93_M140_S0.077970.760
94_A144_L0.077960.760
101_Q110_Y0.077930.759
36_A55_L0.077520.755
100_L104_I0.077520.755
58_L137_L0.077290.753
59_G67_Y0.077090.751
75_C88_A0.076910.749
1_A149_R0.076840.749
7_F17_L0.076680.747
71_L107_L0.076340.744
82_R85_R0.076190.742
104_I141_Y0.076060.741
107_L117_F0.076050.741
21_L31_L0.0760.741
32_A60_G0.075880.739
123_A126_L0.075590.737
2_G95_L0.075160.732
1_A139_F0.075160.732
93_M132_I0.074920.730
23_I121_S0.074810.729
25_L66_G0.074750.728
81_Q84_L0.074720.728
82_R138_L0.07460.727
14_R26_A0.074570.727
92_R143_W0.074430.725
130_L138_L0.074310.724
27_V130_L0.074150.722
76_Q137_L0.074140.722
8_E129_A0.073930.720
130_L134_V0.07380.719
63_L67_Y0.073770.719
96_T141_Y0.073690.718
100_L139_F0.073620.717
155_L159_L0.073240.714
3_R12_E0.073070.712
20_L155_L0.072780.709
89_A133_W0.072210.704
94_A126_L0.072090.702
15_K18_R0.072080.702
14_R25_L0.072030.702
15_K155_L0.072020.702
82_R148_R0.071890.700
14_R18_R0.071760.699
94_A122_P0.071560.697
2_G90_V0.071330.695
101_Q153_E0.07110.693
144_L156_W0.071070.692
1_A65_L0.071020.692
17_L93_M0.070970.691
83_L87_L0.070410.686
93_M139_F0.07020.684
63_L66_G0.070140.683
126_L141_Y0.070090.683
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
1qtxB0.159510.90.941
3mktA0.93878.40.944
4i0uA0.4545.80.947
4ev6A0.4545.30.948
2iubA0.44174.90.949
2o5gB0.15954.70.949
3w4tA0.93254.30.95
4djkA0.95094.30.95
3ixzA0.527640.951
2zxeA0.49693.30.953
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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