GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
SirB - Invasion gene expression up-regulator SirB
Pfam: PF04247 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 123
Sequences: 1220
Seq/Len: 9.92
HH_delta: 0.904 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
51_L82_I0.524672.942
5_L56_G0.515672.891
39_V88_A0.487072.731
3_L6_K0.457982.568
12_F49_L0.417632.341
114_S118_T0.405872.276
15_L46_I0.371332.082
82_I85_G0.349191.958
97_Q101_A0.3491.957
77_L115_L0.343691.927
13_V50_L0.323181.812
8_L53_S0.32231.807
49_L53_S0.314361.762
94_T97_Q0.312311.751
71_L75_L0.310391.740
77_L112_I0.308661.731
10_M117_V0.294561.651
2_Y6_K0.287591.612
77_L111_Y0.275611.545
108_W112_I0.271471.522
96_S101_A0.268391.505
12_F53_S0.268211.504
55_I59_V0.266761.496
72_T76_V0.261411.466
14_A109_F0.25751.444
97_Q102_F0.255791.434
111_Y115_L0.250351.404
69_P72_T0.245681.377
44_H48_T0.234451.314
73_A115_L0.233291.308
39_V85_G0.224461.258
36_K41_I0.223571.253
42_L46_I0.223191.251
7_H114_S0.219531.231
70_W116_A0.211881.188
89_L94_T0.20911.172
26_W97_Q0.208071.167
58_M71_L0.204771.148
16_S50_L0.201631.130
96_S102_F0.200981.127
17_I109_F0.200161.122
16_S47_D0.200061.122
98_R101_A0.188011.054
74_K116_A0.187961.054
104_G108_W0.187741.053
47_D82_I0.18771.052
107_A111_Y0.18731.050
42_L45_I0.186651.046
98_R102_F0.186411.045
60_I63_Q0.184551.035
29_T97_Q0.184251.033
33_W37_K0.183571.029
26_W39_V0.18021.010
85_G88_A0.178070.998
71_L78_L0.178020.998
20_F34_L0.177160.993
6_K119_K0.176240.988
99_W102_F0.175540.984
78_L116_A0.175160.982
89_L95_Q0.17410.976
4_A8_L0.173570.973
11_L110_V0.17320.971
4_A118_T0.1730.970
12_F46_I0.171410.961
80_A108_W0.169750.952
28_L97_Q0.169680.951
52_L56_G0.167920.941
18_L35_Q0.167840.941
54_G89_L0.167450.939
20_F23_R0.164380.922
51_L81_Y0.162730.912
21_V25_L0.162610.912
54_G120_Q0.159430.894
24_F108_W0.159090.892
44_H47_D0.158050.886
65_P68_D0.157950.886
5_L60_I0.157440.883
58_M66_F0.157260.882
34_L37_K0.157040.880
19_L22_L0.155850.874
50_L116_A0.155440.871
12_F15_L0.154490.866
48_T52_L0.153660.862
96_S100_L0.153340.860
96_S99_W0.153160.859
76_V80_A0.151440.849
84_L101_A0.150550.844
47_D50_L0.14880.834
4_A114_S0.147840.829
76_V83_V0.146750.823
43_P85_G0.146250.820
28_L99_W0.14520.814
61_L65_P0.144860.812
62_G69_P0.144660.811
5_L118_T0.144480.810
44_H88_A0.144060.808
20_F109_F0.143160.803
24_F35_Q0.143030.802
7_H118_T0.142670.800
115_L119_K0.14210.797
7_H11_L0.141950.796
29_T32_P0.14180.795
104_G107_A0.141020.791
27_L106_L0.140260.786
14_A17_I0.139440.782
23_R34_L0.139020.779
61_L66_F0.13840.776
91_R107_A0.137520.771
17_I87_I0.136670.766
35_Q89_L0.136360.765
63_Q68_D0.136240.764
10_M13_V0.135720.761
55_I79_I0.135140.758
40_K44_H0.134720.755
26_W37_K0.134320.753
27_L102_F0.133760.750
73_A111_Y0.133680.749
17_I34_L0.133420.748
40_K43_P0.133260.747
62_G67_V0.132740.744
8_L49_L0.132530.743
39_V43_P0.132350.742
36_K91_R0.13220.741
11_L113_V0.13220.741
13_V113_V0.130750.733
5_L57_L0.129760.728
95_Q99_W0.129210.724
2_Y116_A0.129180.724
20_F24_F0.129050.724
71_L119_K0.128810.722
78_L112_I0.128470.720
56_G60_I0.128450.720
114_S120_Q0.127750.716
2_Y88_A0.126510.709
66_F71_L0.126460.709
61_L67_V0.126410.709
16_S74_K0.126170.707
40_K88_A0.125460.703
11_L46_I0.125150.702
51_L55_I0.124710.699
8_L110_V0.124470.698
23_R74_K0.124190.696
16_S78_L0.124110.696
110_V114_S0.124010.695
80_A117_V0.123510.692
22_L26_W0.123120.690
79_I82_I0.122650.688
2_Y63_Q0.122430.686
18_L23_R0.122270.686
66_F72_T0.122220.685
86_I100_L0.121690.682
58_M61_L0.121630.682
57_L65_P0.121440.681
47_D84_L0.121360.680
43_P47_D0.121150.679
79_I83_V0.12110.679
76_V85_G0.121060.679
44_H84_L0.120790.677
23_R98_R0.120240.674
43_P82_I0.119980.673
29_T56_G0.119960.673
51_L85_G0.119180.668
52_L88_A0.119180.668
78_L118_T0.119170.668
44_H85_G0.118580.665
10_M24_F0.118170.663
11_L15_L0.117870.661
86_I99_W0.117840.661
10_M113_V0.116410.653
70_W119_K0.115870.650
37_K41_I0.115780.649
110_V118_T0.115250.646
27_L101_A0.115140.646
69_P121_P0.115020.645
17_I38_W0.114790.644
115_L120_Q0.114610.643
59_V93_R0.11460.643
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
4he8H0.7236160.904
3cx5C0.7886150.905
1pp9C0.77248.70.914
2akhX0.61792.20.935
4gd3A0.89431.60.939
4i0uA0.70731.50.94
2iubA0.73981.20.943
4ev6A0.73981.20.943
3mk7C0.65041.10.945
4fbzA0.50410.90.947
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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