GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
IspA - Intracellular septation protein A
Pfam: PF04279 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 176
Sequences: 1198
Seq/Len: 6.81
HH_delta: 0.913 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
86_A128_L0.290162.534
83_W131_A0.281462.458
123_W165_Q0.276332.413
71_P143_E0.263242.298
75_K143_E0.261352.282
41_W45_R0.257932.252
102_K113_D0.255652.232
63_G67_L0.242632.119
37_V47_V0.240932.104
125_L129_F0.232812.033
86_A90_L0.225111.966
142_S145_T0.221561.935
121_L124_A0.219531.917
86_A124_A0.216651.892
39_Y43_R0.214481.873
16_V24_V0.209381.828
146_W149_F0.209251.827
93_L120_T0.202441.768
30_I59_L0.190421.663
130_L154_L0.186531.629
161_F165_Q0.182381.592
135_E139_Y0.180121.573
163_I166_I0.17581.535
90_L124_A0.175791.535
27_A31_V0.170951.493
93_L117_R0.16531.443
82_N127_F0.162481.419
71_P75_K0.157971.379
122_R161_F0.15631.365
10_L151_V0.154221.347
90_L121_L0.152041.328
159_F163_I0.151841.326
136_Y141_F0.151161.320
94_L97_K0.149721.307
166_I170_R0.147141.285
41_W44_R0.145881.274
141_F145_T0.145881.274
92_S101_L0.144181.259
22_I26_T0.144161.259
143_E147_V0.143931.257
12_L28_V0.142111.241
80_I133_L0.14141.235
21_G24_V0.140391.226
30_I56_V0.140391.226
131_A135_E0.139581.219
126_F161_F0.138341.208
49_K53_I0.136071.188
155_M158_T0.135431.183
79_T134_N0.132621.158
101_L104_L0.13031.138
29_L58_V0.12961.132
55_L156_G0.126591.105
119_L161_F0.125891.099
50_M53_I0.125841.099
88_V91_G0.125611.097
90_L125_L0.124541.087
58_V61_F0.12451.087
112_P118_R0.123761.081
99_P102_K0.122851.073
88_V100_L0.122711.071
7_F10_L0.122681.071
87_A91_G0.122251.067
7_F54_S0.122171.067
34_L55_L0.121551.061
34_L59_L0.120141.049
34_L38_A0.119241.041
118_R121_L0.118831.038
93_L121_L0.118591.035
121_L125_L0.118361.033
167_P170_R0.117841.029
89_L92_S0.117621.027
128_L132_A0.117561.026
130_L157_L0.116191.015
148_N152_F0.115841.011
122_R168_Y0.115241.006
159_F172_H0.114741.002
160_L164_A0.114370.999
160_L163_I0.114030.996
102_K106_G0.113890.994
118_R129_F0.113750.993
68_F75_K0.113270.989
63_G162_V0.111960.978
34_L84_L0.111930.977
82_N130_L0.111760.976
136_Y140_N0.111490.973
13_F26_T0.111490.973
85_F127_F0.111020.969
98_K144_D0.111010.969
47_V98_K0.110710.967
154_L162_V0.110630.966
132_A136_Y0.110630.966
59_L62_G0.109940.960
99_P108_Q0.10980.959
91_G95_F0.109340.955
112_P115_G0.108580.948
7_F103_R0.108560.948
164_A167_P0.108410.947
40_S47_V0.108060.944
16_V70_D0.106960.934
117_R121_L0.106850.933
42_I160_L0.106770.932
35_A109_L0.106710.932
92_S120_T0.106350.929
81_I137_V0.105620.922
52_W55_L0.105520.921
38_A42_I0.105380.920
85_F126_F0.105170.918
160_L167_P0.104730.914
159_F164_A0.104550.913
52_W56_V0.10450.912
23_F66_L0.104370.911
70_D73_F0.104310.911
14_F18_K0.104090.909
156_G160_L0.103990.908
83_W128_L0.103860.907
95_F99_P0.103070.900
78_P130_L0.102640.896
95_F98_K0.102340.894
130_L165_Q0.101050.882
111_L119_L0.100960.882
132_A164_A0.10060.878
114_R118_R0.100560.878
42_I45_R0.100350.876
134_N150_K0.100280.876
7_F155_M0.100060.874
35_A114_R0.099110.865
123_W127_F0.09910.865
136_Y160_L0.098970.864
15_V19_T0.098660.861
91_G94_L0.098160.857
32_A48_P0.097570.852
167_P171_K0.097130.848
126_F157_L0.096690.844
34_L41_W0.096630.844
50_M70_D0.09660.843
82_N89_L0.096550.843
75_K134_N0.096460.842
7_F158_T0.096240.840
22_I65_T0.095750.836
111_L115_G0.095550.834
123_W158_T0.095340.832
11_I64_L0.094950.829
25_A45_R0.094630.826
83_W118_R0.093790.819
17_Y120_T0.093020.812
65_T73_F0.093010.812
165_Q169_L0.092860.811
151_V155_M0.092460.807
46_K88_V0.092370.807
10_L25_A0.092130.804
27_A58_V0.092050.804
38_A41_W0.0920.803
91_G162_V0.091340.798
23_F112_P0.091320.797
21_G138_A0.091260.797
70_D111_L0.091220.796
109_L117_R0.090990.794
49_K92_S0.090850.793
75_K138_A0.090250.788
157_L171_K0.090050.786
23_F27_A0.089780.784
122_R135_E0.089680.783
103_R120_T0.089660.783
80_I84_L0.089630.783
91_G124_A0.089620.783
143_E148_N0.089350.780
16_V28_V0.088760.775
56_V172_H0.088540.773
34_L37_V0.08850.773
109_L129_F0.088420.772
38_A97_K0.088160.770
24_V38_A0.088050.769
72_R76_W0.087980.768
63_G97_K0.087930.768
7_F12_L0.087910.768
126_F135_E0.087710.766
33_T46_K0.08770.766
21_G25_A0.087620.765
53_I57_L0.087580.765
59_L63_G0.08750.764
59_L101_L0.087430.763
64_L67_L0.08730.762
79_T131_A0.087210.761
33_T55_L0.087110.761
11_I19_T0.087040.760
35_A128_L0.086890.759
90_L94_L0.086820.758
12_L103_R0.086460.755
53_I68_F0.086450.755
74_I138_A0.086380.754
164_A168_Y0.086250.753
62_G70_D0.086240.753
59_L164_A0.086240.753
159_F169_L0.086090.752
28_V54_S0.085930.750
16_V20_Y0.085860.750
92_S99_P0.085860.750
32_A104_L0.085750.749
129_F133_L0.085510.747
11_I25_A0.085430.746
41_W57_L0.08520.744
157_L160_L0.085160.744
81_I126_F0.085160.744
34_L45_R0.085130.743
75_K79_T0.085030.742
16_V66_L0.084920.741
129_F145_T0.084840.741
10_L14_F0.084490.738
130_L134_N0.084420.737
23_F69_H0.084220.735
39_Y42_I0.084160.735
114_R159_F0.084140.735
31_V42_I0.084090.734
152_F156_G0.08390.733
77_K134_N0.08380.732
46_K107_K0.083760.731
23_F91_G0.08360.730
10_L83_W0.083430.728
116_W153_G0.083360.728
88_V111_L0.083290.727
146_W161_F0.083270.727
99_P170_R0.083150.726
31_V107_K0.082960.724
35_A39_Y0.082910.724
152_F163_I0.082880.724
24_V27_A0.082710.722
13_F22_I0.082520.721
32_A54_S0.08250.720
11_I15_V0.082320.719
87_A160_L0.082170.717
50_M56_V0.08210.717
66_L69_H0.081950.716
38_A72_R0.081630.713
76_W139_Y0.081620.713
51_Q61_F0.081530.712
100_L104_L0.081320.710
148_N153_G0.081050.708
18_K104_L0.081030.708
60_V66_L0.080980.707
16_V19_T0.080940.707
24_V36_Q0.080860.706
39_Y47_V0.080660.704
142_S168_Y0.080660.704
73_F129_F0.08040.702
134_N146_W0.08030.701
112_P172_H0.080190.700
89_L161_F0.080180.700
80_I83_W0.080040.699
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2xq2A0.948933.70.913
3b9wA0.914812.40.928
3giaA0.89774.30.941
4ainA0.96023.20.944
4a2nB0.54553.20.944
4humA0.33522.90.946
4djkA0.94892.70.946
2wswA0.97162.60.946
2jwaA0.24432.40.948
1wazA0.26142.20.948
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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