GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF454 - Protein of unknown function (DUF454)
Pfam: PF04304 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 71
Sequences: 739
Seq/Len: 10.41
HH_delta: 0.868 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
2_H19_E0.473612.502
2_H6_L0.41962.217
16_R20_E0.389072.056
33_L69_L0.381022.013
3_R7_N0.363031.918
37_W65_A0.345681.826
60_I64_V0.33431.766
27_K31_R0.31511.665
38_L42_I0.30551.614
8_H11_F0.266641.409
4_W8_H0.263681.393
6_L19_E0.258381.365
64_V68_I0.2561.353
51_L55_I0.253011.337
63_I67_Y0.250821.325
7_N16_R0.24541.297
55_I59_A0.239771.267
40_M61_L0.239281.264
30_I34_L0.238341.259
62_L69_L0.225951.194
45_F56_V0.224051.184
50_N53_V0.221361.170
25_P28_A0.22091.167
45_F54_R0.218931.157
5_L11_F0.217521.149
24_I70_R0.215411.138
10_L13_P0.213351.127
51_L54_R0.212821.124
1_F70_R0.2111.115
39_S43_S0.208951.104
52_W59_A0.201961.067
60_I63_I0.196771.040
52_W56_V0.196181.037
24_I68_I0.192491.017
35_M39_S0.186280.984
8_H13_P0.184980.977
66_I69_L0.183930.972
1_F4_W0.183770.971
56_V60_I0.183180.968
15_I31_R0.182670.965
1_F5_L0.182450.964
59_A63_I0.180190.952
38_L41_G0.179850.950
30_I33_L0.177650.939
48_V53_V0.173230.915
47_F53_V0.171660.907
52_W55_I0.171420.906
40_M45_F0.171030.904
61_L65_A0.169860.898
12_G16_R0.166760.881
14_Y17_N0.166590.880
14_Y18_W0.165090.872
26_R31_R0.163870.866
4_W7_N0.162590.859
9_R13_P0.160310.847
23_G29_K0.160310.847
5_L10_L0.160060.846
63_I66_I0.159660.844
1_F61_L0.159550.843
48_V55_I0.159330.842
30_I43_S0.159250.841
40_M57_L0.155340.821
33_L40_M0.155130.820
9_R14_Y0.15380.813
58_A62_L0.1530.808
65_A69_L0.152380.805
53_V60_I0.151220.799
48_V51_L0.149980.792
49_P54_R0.149970.792
48_V56_V0.149290.789
42_I69_L0.149180.788
48_V54_R0.146550.774
21_H41_G0.146510.774
42_I46_F0.146170.772
36_M39_S0.145810.770
33_L65_A0.14550.769
30_I62_L0.144640.764
50_N55_I0.144250.762
20_E49_P0.144070.761
36_M65_A0.141380.747
48_V57_L0.140090.740
22_R70_R0.138710.733
37_W40_M0.138070.730
42_I55_I0.137510.727
57_L64_V0.137420.726
51_L70_R0.136780.723
65_A68_I0.136670.722
25_P35_M0.135820.718
16_R32_A0.135670.717
16_R39_S0.135430.716
11_F14_Y0.134370.710
24_I33_L0.134060.708
40_M55_I0.134040.708
57_L67_Y0.133750.707
37_W41_G0.132870.702
39_S64_V0.132840.702
11_F32_A0.13280.702
58_A63_I0.132560.700
46_F62_L0.132540.700
56_V59_A0.131420.694
64_V67_Y0.129480.684
3_R58_A0.129360.684
57_L60_I0.128450.679
53_V69_L0.126610.669
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3tx3A0.929612.60.868
2ebzA0.49310.10.873
4eneA0.38038.80.876
3lnuA0.39446.90.881
3tiaA0.53526.50.883
2ckaA0.39445.90.885
4ekfA0.42255.20.887
1nmbN0.56344.50.891
4b7jA0.521140.894
4g31A0.36623.70.894
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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