GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF457 - Predicted membrane-bound metal-dependent hydrolase (DUF457)
Pfam: PF04307 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0368
Length: 157
Sequences: 874
Seq/Len: 5.57
HH_delta: 0.945 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
102_L112_V0.290392.644
36_L94_F0.220742.010
60_R108_T0.214361.952
33_G97_G0.205081.868
40_D59_H0.191741.746
73_A95_F0.186471.698
100_S104_L0.185071.685
60_R111_G0.179031.630
115_F123_F0.178541.626
36_L39_I0.17641.606
106_L114_L0.172541.571
11_L103_L0.167471.525
102_L114_L0.167181.522
46_I61_G0.163081.485
5_A31_V0.162881.483
34_A100_S0.162261.478
132_S136_N0.156511.425
73_A91_A0.154411.406
7_V104_L0.154391.406
40_D60_R0.153851.401
131_S136_N0.152271.387
40_D61_G0.152121.385
108_T111_G0.149351.360
78_L82_R0.145781.328
88_R115_F0.145731.327
66_L70_L0.145091.321
33_G94_F0.144651.317
87_W118_F0.144551.316
29_A33_G0.142131.294
40_D108_T0.134311.223
8_G104_L0.127151.158
12_A129_F0.125661.144
48_N51_G0.124421.133
8_G12_A0.123451.124
133_S136_N0.122721.118
73_A115_F0.122531.116
44_S98_Y0.122231.113
60_R63_T0.121911.110
12_A91_A0.120891.101
4_H34_A0.120181.094
29_A76_L0.118751.081
74_L78_L0.118671.081
73_A96_I0.118041.075
130_S136_N0.117621.071
7_V100_S0.117281.068
108_T136_N0.117181.067
106_L115_F0.115861.055
29_A94_F0.115311.050
9_L13_A0.115011.047
30_A34_A0.114581.043
47_G54_S0.114541.043
53_L71_I0.113741.036
59_H108_T0.113461.033
40_D64_H0.112811.027
8_G108_T0.112761.027
59_H64_H0.112581.025
86_G115_F0.112531.025
60_R112_V0.112331.023
78_L125_L0.112271.022
65_S114_L0.112181.022
119_S123_F0.112151.021
60_R64_H0.11191.019
62_F104_L0.111841.018
42_P97_G0.111541.016
39_I63_T0.110961.010
66_L69_A0.110881.010
3_T8_G0.11081.009
92_L95_F0.110541.007
44_S48_N0.110541.007
9_L31_V0.10970.999
7_V10_A0.10920.994
14_A29_A0.108030.984
69_A95_F0.107670.980
13_A51_G0.107230.976
103_L107_L0.106760.972
130_S133_S0.106580.971
74_L96_I0.106550.970
104_L108_T0.10650.970
68_F98_Y0.10630.968
9_L116_W0.106270.968
70_L95_F0.106050.966
128_I132_S0.105780.963
32_I71_I0.104840.955
36_L124_S0.103520.943
41_H52_P0.103270.940
95_F103_L0.1030.938
112_V124_S0.102670.935
80_A94_F0.102580.934
41_H108_T0.102540.934
77_W95_F0.10250.933
44_S47_G0.102220.931
82_R88_R0.102020.929
97_G127_I0.101610.925
23_N75_I0.100030.911
47_G52_P0.099680.908
42_P98_Y0.099340.905
6_L9_L0.098970.901
12_A26_A0.098820.900
59_H111_G0.098530.897
110_Y132_S0.097830.891
31_V34_A0.097810.891
3_T23_N0.097520.888
112_V132_S0.096990.883
2_L127_I0.096790.881
28_A31_V0.096660.880
128_I133_S0.09660.880
69_A73_A0.096540.879
65_S115_F0.096230.876
110_Y133_S0.095850.873
69_A102_L0.095670.871
129_F135_V0.09560.871
131_S135_V0.094330.859
74_L95_F0.094210.858
34_A45_F0.093930.855
76_L99_L0.09340.851
5_A35_L0.092770.845
74_L87_W0.092560.843
81_R99_L0.092480.842
65_S117_P0.092230.840
66_L88_R0.09220.840
5_A109_G0.091920.837
36_L76_L0.091910.837
41_H100_S0.091840.836
40_D98_Y0.091780.836
10_A53_L0.091280.831
107_L114_L0.0910.829
33_G89_W0.090860.827
108_T122_R0.090240.822
98_Y102_L0.090090.820
26_A30_A0.089770.817
42_P104_L0.089720.817
45_F74_L0.089490.815
113_P122_R0.089410.814
54_S126_P0.089290.813
2_L132_S0.089160.812
69_A114_L0.088830.809
62_F78_L0.088730.808
11_L89_W0.088680.808
99_L114_L0.088610.807
65_S69_A0.088570.807
77_W87_W0.088490.806
15_L90_I0.088430.805
15_L27_I0.088390.805
23_N27_I0.087990.801
61_G111_G0.087840.800
70_L123_F0.087750.799
36_L47_G0.087740.799
15_L28_A0.087640.798
62_F116_W0.087390.796
6_L114_L0.087240.794
2_L41_H0.087170.794
113_P116_W0.087170.794
44_S97_G0.086960.792
12_A93_A0.086630.789
62_F103_L0.08650.788
11_L30_A0.085960.783
61_G76_L0.085960.783
54_S68_F0.085310.777
132_S135_V0.08480.772
2_L136_N0.084640.771
126_P129_F0.084470.769
9_L34_A0.084470.769
62_F108_T0.084020.765
77_W91_A0.083870.764
38_D59_H0.083850.764
73_A106_L0.083830.763
4_H135_V0.083550.761
8_G30_A0.083510.760
42_P61_G0.082910.755
107_L116_W0.08280.754
23_N28_A0.082740.753
36_L98_Y0.082640.753
75_I91_A0.082580.752
68_F128_I0.082570.752
14_A82_R0.082020.747
59_H63_T0.081810.745
3_T112_V0.081460.742
25_A78_L0.081460.742
11_L32_I0.081280.740
40_D116_W0.081130.739
15_L55_S0.080820.736
112_V130_S0.080750.735
94_F99_L0.080310.731
77_W96_I0.080220.731
61_G65_S0.079890.728
103_L127_I0.079820.727
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3ii6X0.33763.30.945
4he8L0.60512.90.946
3nd0A0.605120.95
4he8M0.57961.80.951
1dx7A0.30571.20.956
1nbwA0.49041.10.957
2zy9A0.92361.10.957
3rvyA0.337610.957
4gicA0.33760.80.959
2b19A0.19110.80.96
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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