GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Glyco_hydro_43 - Glycosyl hydrolases family 43
Pfam: PF04616 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0143
Length: 286
Sequences: 3401
Seq/Len: 11.89
HH_delta: 0.156 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
131_K152_E1.100216.023
42_D45_N0.977975.354
191_K213_D0.854774.680
78_K100_D0.76074.165
21_G39_S0.759924.160
191_K211_R0.672143.680
78_K98_T0.599113.280
128_D187_K0.593053.247
25_Y106_W0.588053.219
252_R277_P0.57283.136
152_E161_T0.555753.043
99_A105_P0.543992.978
21_G41_K0.516762.829
248_D252_R0.438842.402
39_S49_A0.411752.254
17_R20_D0.38792.124
126_V132_Y0.382522.094
154_D159_S0.375672.057
18_F79_Y0.370772.030
156_D159_S0.364791.997
72_I81_M0.364691.997
135_Y150_I0.361791.981
74_Y77_G0.344991.889
22_Y40_S0.343921.883
150_I216_L0.340921.866
247_K251_G0.336841.844
245_V278_V0.33461.832
247_K253_W0.332581.821
154_D158_T0.317151.736
151_A160_L0.310411.699
39_S47_T0.305311.671
25_Y72_I0.300761.647
215_P219_W0.299791.641
52_V81_M0.295451.617
20_D41_K0.292681.602
213_D220_E0.290611.591
195_F209_Y0.284011.555
211_R220_E0.27461.503
39_S103_D0.274171.501
257_Y276_Q0.273861.499
207_V255_I0.271831.488
135_Y215_P0.268851.472
136_Y151_A0.265811.455
154_D161_T0.263211.441
188_H280_W0.262811.439
125_F185_V0.26261.438
82_Y157_G0.262391.436
35_I81_M0.262261.436
212_S219_W0.260221.425
98_T109_P0.260031.424
135_Y185_V0.256171.402
155_P158_T0.254161.391
40_S43_L0.251841.379
198_A208_G0.246111.347
25_Y102_P0.24581.346
71_E123_S0.24581.346
80_Y96_V0.244381.338
101_S105_P0.242221.326
187_K192_Y0.241821.324
186_F195_F0.24161.323
99_A102_P0.241011.319
15_I256_V0.240591.317
253_W280_W0.236861.297
98_T107_T0.235671.290
74_Y79_Y0.23431.283
16_V79_Y0.233351.278
154_D157_G0.232891.275
18_F21_G0.231441.267
36_P51_N0.230691.263
127_D187_K0.229881.259
259_A274_R0.228061.249
43_L275_I0.226551.240
99_A104_G0.226481.240
26_G38_W0.225351.234
99_A103_D0.224661.230
69_A242_H0.223741.225
40_S46_W0.220841.209
17_R249_P0.219851.204
37_V72_I0.219221.200
226_P229_F0.219191.200
185_V219_W0.214521.174
12_D121_D0.214121.172
166_V216_L0.212031.161
127_D192_Y0.211881.160
190_G213_D0.211581.158
40_S44_V0.210691.153
254_Y277_P0.210581.153
36_P48_D0.209891.149
10_Y38_W0.209791.149
100_D107_T0.208331.141
214_S219_W0.203321.113
135_Y219_W0.202791.110
150_I215_P0.202611.109
23_Y37_V0.201131.101
214_S217_G0.200971.100
42_D46_W0.200871.100
12_D69_A0.199721.093
256_V275_I0.199091.090
28_T34_G0.19861.087
186_F245_V0.198111.085
57_P108_D0.197421.081
10_Y26_G0.196321.075
255_I278_V0.19611.074
150_I219_W0.195361.070
121_D181_E0.192431.053
83_Y97_A0.189631.038
153_L158_T0.188721.033
82_Y124_V0.188591.032
80_Y98_T0.18831.031
18_F74_Y0.188181.030
82_Y134_L0.187961.029
22_Y248_D0.187721.028
211_R222_K0.187271.025
125_F215_P0.186941.023
125_F192_Y0.184861.012
69_A121_D0.183171.003
248_D254_Y0.182861.001
17_R247_K0.18120.992
70_P81_M0.180420.988
193_Y209_Y0.180190.986
186_F280_W0.178570.978
239_G260_R0.178330.976
184_F244_S0.176830.968
133_Y216_L0.176170.964
95_G108_D0.175690.962
195_F245_V0.174480.955
212_S218_P0.17430.954
152_E162_G0.173890.952
82_Y96_V0.173060.947
129_D187_K0.172910.947
138_S149_Y0.171540.939
35_I83_Y0.171110.937
12_D181_E0.1710.936
101_S106_W0.170950.936
151_A162_G0.170080.931
102_P106_W0.169340.927
75_I132_Y0.169120.926
53_L97_A0.166080.909
37_V52_V0.165750.907
244_S256_V0.165670.907
237_V274_R0.164790.902
22_Y27_T0.163660.896
101_S104_G0.163460.895
11_A271_R0.161660.885
22_Y43_L0.16080.880
41_K47_T0.160650.880
121_D242_H0.160320.878
124_V134_L0.159420.873
196_Y210_A0.159110.871
85_D88_G0.158930.870
89_D92_S0.157760.864
149_Y166_V0.157640.863
35_I70_P0.157460.862
191_K212_S0.156780.858
94_I122_P0.15580.853
94_I134_L0.154890.848
195_F243_G0.153520.840
209_Y227_I0.153460.840
12_D27_T0.153180.839
237_V259_A0.1530.838
73_H126_V0.15270.836
127_D130_G0.152480.835
69_A181_E0.152380.834
27_T70_P0.151430.829
188_H253_W0.151070.827
243_G255_I0.150330.823
83_Y95_G0.150270.823
15_I244_S0.14910.816
120_I183_P0.14910.816
96_V158_T0.148990.816
77_G98_T0.148630.814
40_S45_N0.148470.813
25_Y37_V0.148350.812
109_P158_T0.148270.812
257_Y274_R0.148270.812
133_Y152_E0.148180.811
195_F207_V0.147560.808
153_L157_G0.147430.807
217_G220_E0.147090.805
169_F210_A0.14690.804
125_F129_D0.146560.802
133_Y150_I0.145770.798
124_V132_Y0.145550.797
180_V196_Y0.145160.795
148_I194_L0.144680.792
196_Y208_G0.144270.790
125_F187_K0.143910.788
212_S215_P0.143860.788
12_D68_W0.143540.786
212_S217_G0.143340.785
187_K190_G0.142130.778
215_P218_P0.141910.777
15_I24_L0.141870.777
249_P252_R0.141860.777
261_N272_S0.141120.773
197_S241_G0.14070.770
179_V182_G0.140130.767
69_A182_G0.139860.766
195_F280_W0.139830.766
49_A103_D0.13920.762
17_R22_Y0.138860.760
83_Y108_D0.138690.759
12_D242_H0.138240.757
254_Y275_I0.137670.754
197_S205_Y0.137230.751
237_V240_P0.137010.750
205_Y241_G0.136870.749
19_G74_Y0.136480.747
17_R248_D0.136230.746
135_Y183_P0.136070.745
27_T69_A0.135780.743
136_Y149_Y0.135730.743
148_I183_P0.135610.742
28_T36_P0.135190.740
197_S258_H0.134690.737
55_P58_D0.134010.734
26_G182_G0.13380.733
22_Y249_P0.133470.731
102_P105_P0.133220.729
97_A109_P0.13280.727
57_P61_W0.132030.723
240_P259_A0.131330.719
80_Y156_D0.130840.716
69_A120_I0.129950.711
270_G280_W0.129020.706
76_N80_Y0.128970.706
207_V241_G0.128840.705
121_D182_G0.128640.704
21_G49_A0.128440.703
68_W181_E0.128210.702
53_L81_M0.127980.701
195_F278_V0.127980.701
246_F256_V0.127780.700
97_A106_W0.127720.699
201_T260_R0.127310.697
153_L156_D0.126890.695
81_M97_A0.126830.694
38_W48_D0.126770.694
22_Y246_F0.126540.693
74_Y275_I0.125810.689
207_V243_G0.125050.685
242_H258_H0.124740.683
127_D217_G0.124570.682
84_S122_P0.124050.679
193_Y211_R0.124040.679
248_D251_G0.123980.679
15_I273_T0.123310.675
63_N90_A0.122810.672
126_V129_D0.122650.671
225_N229_F0.120910.662
166_V169_F0.120890.662
48_D51_N0.120880.662
270_G275_I0.120770.661
35_I97_A0.120620.660
214_S218_P0.120270.658
25_Y70_P0.120260.658
14_S71_E0.120140.658
188_H247_K0.120060.657
151_A164_P0.119670.655
136_Y164_P0.119310.653
15_I22_Y0.118320.648
43_L46_W0.118110.647
23_Y79_Y0.117860.645
134_L182_G0.11760.644
79_Y97_A0.117390.643
125_F131_K0.117330.642
127_D215_P0.117150.641
188_H191_K0.116290.637
236_G261_N0.11620.636
23_Y39_S0.11580.634
123_S184_F0.115790.634
10_Y24_L0.115620.633
122_P134_L0.115620.633
276_Q279_T0.115410.632
17_R246_F0.114520.627
10_Y273_T0.114470.627
255_I276_Q0.114390.626
155_P161_T0.11430.626
73_H246_F0.114120.625
34_G51_N0.113940.624
197_S239_G0.113890.624
192_Y217_G0.113670.622
125_F133_Y0.113490.621
135_Y194_L0.113470.621
256_V273_T0.113170.620
25_Y29_D0.113160.620
131_K155_P0.112930.618
82_Y94_I0.112850.618
182_G205_Y0.112780.617
109_P112_I0.112620.617
37_V106_W0.11250.616
160_L164_P0.112390.615
198_A206_Q0.112170.614
69_A258_H0.112020.613
73_H132_Y0.111860.612
84_S94_I0.111820.612
151_A161_T0.111670.611
186_F253_W0.111520.611
117_G160_L0.111430.610
28_T33_P0.11110.608
133_Y215_P0.111020.608
26_G36_P0.110930.607
120_I258_H0.110810.607
206_Q226_P0.110690.606
278_V281_D0.110410.604
189_G251_G0.110120.603
243_G256_V0.10970.601
148_I196_Y0.109210.598
85_D89_D0.10920.598
60_D63_N0.109060.597
27_T205_Y0.108910.596
13_P69_A0.108820.596
121_D197_S0.108130.592
197_S243_G0.107880.591
136_Y150_I0.107530.589
182_G207_V0.107440.588
148_I180_V0.107310.587
139_W179_V0.107130.587
163_E166_V0.106390.582
109_P157_G0.106360.582
194_L219_W0.106350.582
27_T120_I0.106280.582
100_D213_D0.106240.582
121_D258_H0.106140.581
129_D133_Y0.105760.579
74_Y98_T0.105720.579
48_D52_V0.10570.579
169_F221_W0.105470.577
73_H124_V0.105280.576
71_E122_P0.105270.576
40_S275_I0.104860.574
94_I97_A0.10480.574
137_G179_V0.104780.574
71_E258_H0.104760.574
205_Y258_H0.104750.573
24_L38_W0.104650.573
254_Y257_Y0.104620.573
199_G206_Q0.104060.570
71_E242_H0.103910.569
125_F128_D0.103830.568
24_L273_T0.103690.568
126_V130_G0.103470.566
269_G272_S0.103370.566
131_K161_T0.103140.565
180_V210_A0.103080.564
120_I242_H0.102950.564
76_N132_Y0.102850.563
29_D33_P0.102470.561
169_F172_D0.102410.561
181_E197_S0.102390.561
27_T68_W0.102230.560
162_G167_V0.101940.558
51_N54_P0.101780.557
247_K252_R0.101330.555
216_L220_E0.101080.553
177_G221_W0.100990.553
215_P220_E0.100940.553
50_G54_P0.100810.552
73_H123_S0.100660.551
169_F281_D0.100650.551
79_Y106_W0.100470.550
150_I168_I0.100470.550
14_S244_S0.100390.550
155_P189_G0.100340.549
58_D66_N0.099980.547
139_W147_G0.099750.546
228_L257_Y0.099470.545
68_W120_I0.099330.544
260_R272_S0.099320.544
127_D213_D0.099230.543
192_Y219_W0.099160.543
41_K279_T0.098980.542
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1yrzA0.97551000.156
3c2uA0.9721000.162
1yifA0.9721000.169
2exhA0.9721000.169
3qz4A0.9651000.172
3qeeA0.91261000.198
3kstA0.9511000.199
3zxkA0.88811000.205
3c7fA0.94411000.208
3cpnA0.97551000.21

Page generated in 0.0286 seconds.