GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF624 - Protein of unknown function DUF624
Pfam: PF04854 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 77
Sequences: 493
Seq/Len: 6.4
HH_delta: 0.888 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
8_W25_T0.773294.736
17_P20_T0.457012.799
15_G20_T0.428162.623
23_P60_L0.365982.242
22_G63_G0.353532.165
30_Y51_A0.298091.826
8_W28_L0.29551.810
72_I76_D0.280521.718
20_T60_L0.255531.565
5_N9_L0.249771.530
14_A48_F0.237781.456
36_V39_E0.222181.361
26_A59_S0.221991.360
31_V35_W0.219731.346
6_L68_L0.214911.316
14_A49_W0.212781.303
56_F60_L0.208531.277
71_A74_Y0.205211.257
30_Y48_F0.205111.256
45_F49_W0.19641.203
43_Y46_R0.194321.190
13_L68_L0.190071.164
46_R53_K0.188261.153
43_Y76_D0.187721.150
20_T23_P0.186211.141
43_Y47_D0.180691.107
56_F59_S0.179511.100
14_A17_P0.174231.067
15_G23_P0.168321.031
3_V45_F0.163851.004
47_D50_R0.16341.001
32_V36_V0.162670.996
23_P52_F0.162340.994
13_L17_P0.158450.971
13_L42_S0.157370.964
3_V7_L0.153120.938
31_V57_K0.152660.935
41_D63_G0.151540.928
60_L63_G0.151440.928
70_L73_L0.151290.927
13_L54_Q0.150470.922
61_L69_L0.14620.895
62_L68_L0.145150.889
15_G60_L0.145030.888
16_L19_F0.144720.886
4_L28_L0.143220.877
4_L74_Y0.142830.875
52_F59_S0.142820.875
33_R61_L0.142730.874
50_R54_Q0.140950.863
24_A36_V0.139980.857
21_I56_F0.137120.840
17_P52_F0.136570.837
19_F56_F0.135940.833
37_R44_L0.133870.820
62_L66_L0.133460.817
64_L67_L0.133180.816
65_I75_V0.132080.809
52_F60_L0.13060.800
17_P60_L0.130590.800
19_F73_L0.128430.787
9_L46_R0.127880.783
67_L73_L0.127550.781
61_L67_L0.127230.779
22_G28_L0.126740.776
6_L75_V0.126050.772
26_A63_G0.125040.766
26_A55_N0.124570.763
58_Q61_L0.124540.763
26_A51_A0.12420.761
16_L50_R0.123920.759
15_G21_I0.123380.756
30_Y34_K0.122980.753
14_A24_A0.119020.729
44_L51_A0.118990.729
68_L73_L0.117720.721
51_A55_N0.116690.715
69_L76_D0.116640.714
67_L71_A0.115880.710
24_A61_L0.115870.710
49_W53_K0.114680.702
31_V41_D0.114560.702
72_I75_V0.114360.700
15_G42_S0.114150.699
6_L47_D0.113150.693
18_V36_V0.112740.691
15_G52_F0.11250.689
22_G55_N0.112480.689
22_G59_S0.112010.686
57_K61_L0.111990.686
8_W29_Y0.111430.683
2_V7_L0.110650.678
24_A46_R0.110640.678
55_N59_S0.110580.677
37_R54_Q0.11050.677
27_A48_F0.107220.657
58_Q62_L0.106450.652
20_T24_A0.106320.651
5_N27_A0.105910.649
24_A52_F0.105790.648
7_L27_A0.105270.645
31_V51_A0.105050.643
5_N66_L0.104620.641
52_F56_F0.104120.638
20_T52_F0.1040.637
37_R64_L0.10390.636
15_G19_F0.103730.635
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3tx3A0.935160.888
3hzqA0.64944.80.892
4humA0.49354.50.894
2zy9A0.92214.20.895
2i2jA0.33773.70.898
3k3fA0.63643.60.898
3um7A0.67533.40.899
2kdcA0.64942.90.903
3ibvA0.74032.80.903
2w3zA0.44162.70.904
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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