GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
HPP - HPP family
Pfam: PF04982 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0307
Length: 120
Sequences: 703
Seq/Len: 5.86
HH_delta: 0.911 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
40_L89_W0.453743.129
19_S22_A0.437273.015
45_F54_L0.377422.603
31_H76_T0.329592.273
33_I62_L0.306932.117
27_V104_V0.295832.040
28_I104_V0.286971.979
6_F99_G0.28511.966
31_H100_S0.276641.908
5_S31_H0.272631.880
29_G68_T0.264181.822
34_S73_A0.262341.809
34_S59_A0.257771.778
13_L103_L0.256051.766
39_V80_A0.241321.664
38_G80_A0.237011.634
13_L27_V0.223061.538
37_I62_L0.216591.494
33_I66_T0.214931.482
25_R68_T0.213961.475
3_L96_V0.211671.460
39_V92_V0.209111.442
16_A21_L0.205041.414
11_V74_G0.201371.389
32_L97_L0.200451.382
73_A77_A0.199241.374
9_S27_V0.196781.357
23_Q118_Y0.195081.345
59_A63_M0.193791.336
110_F114_I0.188321.299
23_Q119_P0.183351.264
4_P79_L0.183191.263
5_S76_T0.18241.258
111_N116_R0.182351.257
11_V69_V0.180881.247
21_L74_G0.17951.238
49_W53_A0.177861.226
7_G78_L0.176661.218
11_V60_I0.17331.195
5_S79_L0.172661.191
108_L112_N0.166691.149
111_N119_P0.166261.146
28_I101_L0.165821.143
40_L44_L0.162171.118
79_L83_G0.161251.112
13_L107_A0.160891.109
25_R99_G0.158641.094
112_N119_P0.153391.058
26_N99_G0.148341.023
5_S100_S0.148031.021
30_G59_A0.147611.018
12_L22_A0.147131.015
97_L101_L0.147061.014
15_G118_Y0.146141.008
40_L43_Y0.145671.005
7_G74_G0.145351.002
78_L105_V0.144380.996
41_C54_L0.142720.984
42_V81_V0.141330.975
108_L118_Y0.140320.968
41_C58_L0.139970.965
63_M70_H0.139370.961
105_V109_L0.138830.957
69_V73_A0.138810.957
15_G60_I0.13850.955
33_I37_I0.138050.952
6_F91_F0.137610.949
52_A81_V0.137590.949
55_A81_V0.133340.919
10_A31_H0.132950.917
40_L80_A0.13160.907
53_A106_V0.13140.906
30_G34_S0.131240.905
18_S93_L0.131070.904
41_C44_L0.130680.901
76_T80_A0.130570.900
3_L78_L0.12990.896
38_G42_V0.129860.895
30_G70_H0.129830.895
60_I69_V0.128580.887
12_L74_G0.12780.881
85_A88_G0.127790.881
1_L49_W0.125440.865
36_L40_L0.125260.864
45_F48_P0.124420.858
69_V103_L0.122870.847
13_L67_R0.122470.845
8_A12_L0.121960.841
34_S63_M0.121210.836
5_S8_A0.121090.835
9_S30_G0.120360.830
32_L92_V0.120130.828
6_F13_L0.120110.828
25_R67_R0.119510.824
61_V67_R0.118850.820
27_V85_A0.118820.819
66_T110_F0.117890.813
67_R106_V0.117840.813
68_T99_G0.117380.809
43_Y117_R0.117290.809
3_L92_V0.116830.806
50_W53_A0.115960.800
77_A81_V0.115320.795
33_I65_L0.115270.795
36_L92_V0.11520.794
73_A76_T0.114860.792
39_V43_Y0.114520.790
32_L100_S0.113680.784
42_V46_G0.112940.779
32_L94_I0.112160.773
103_L114_I0.111870.771
109_L112_N0.111780.771
43_Y89_W0.111310.768
40_L92_V0.111190.767
10_A39_V0.111120.766
39_V93_L0.11070.763
106_V113_L0.110120.759
17_P22_A0.10970.756
33_I86_S0.109260.753
18_S68_T0.109220.753
11_V95_P0.109150.753
39_V95_P0.108440.748
109_L113_L0.107910.744
78_L96_V0.107770.743
12_L70_H0.106780.736
32_L73_A0.106530.735
34_S77_A0.106280.733
70_H95_P0.105580.728
61_V105_V0.105550.728
42_V80_A0.10540.727
10_A77_A0.105360.727
17_P54_L0.105150.725
4_P14_F0.104540.721
73_A99_G0.103840.716
67_R103_L0.103260.712
2_L5_S0.10280.709
30_G107_A0.102370.706
96_V100_S0.102240.705
14_F110_F0.102020.704
2_L114_I0.101940.703
56_V60_I0.101480.700
62_L116_R0.101270.698
67_R114_I0.101260.698
7_G83_G0.101210.698
61_V109_L0.100780.695
16_A19_S0.100560.693
11_V15_G0.10050.693
78_L83_G0.100380.692
9_S31_H0.10020.691
63_M95_P0.099990.690
41_C55_A0.099980.689
52_A106_V0.099890.689
9_S29_G0.099540.686
103_L110_F0.099450.686
77_A80_A0.099440.686
40_L62_L0.099250.684
108_L111_N0.099030.683
8_A77_A0.098450.679
11_V21_L0.096930.668
4_P20_P0.096760.667
53_A98_L0.096730.667
23_Q112_N0.096710.667
60_I89_W0.096170.663
4_P88_G0.096090.663
73_A100_S0.095610.659
10_A64_V0.09510.656
39_V91_F0.095020.655
111_N118_Y0.094870.654
41_C51_A0.094770.654
56_V106_V0.094740.653
36_L44_L0.094550.652
38_G84_G0.094270.650
47_D117_R0.094190.650
106_V109_L0.094080.649
90_G94_I0.093970.648
58_L62_L0.093820.647
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2l8sA0.325220.911
2k1aA0.333318.20.914
3orgA0.92517.50.914
2kncA0.358313.30.919
2kncB0.38336.80.928
3iyzA0.94176.60.928
4dveA0.76673.20.938
2zz9A0.9752.70.94
1fftB0.60832.60.941
2k9jB0.35832.60.941
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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