GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
FtsL - Cell division protein FtsL
Pfam: PF04999 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0225
Length: 97
Sequences: 1067
Seq/Len: 11
HH_delta: 0.805 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
73_R77_I0.497132.933
75_E79_R0.388772.294
58_N65_I0.332611.962
77_I81_K0.314941.858
76_R80_E0.313041.847
88_E91_Q0.270151.594
22_V25_I0.266991.575
64_E67_T0.266381.571
44_L48_E0.258881.527
50_E53_Q0.250131.476
34_R37_S0.238081.405
68_L73_R0.235951.392
56_E60_R0.22911.352
54_L58_N0.226591.337
50_E54_L0.224671.325
69_S74_I0.222861.315
75_E86_P0.218641.290
23_V30_V0.217731.284
33_S37_S0.214321.264
57_E60_R0.210881.244
43_E46_Q0.208651.231
58_N62_R0.208161.228
51_I55_Q0.202221.193
54_L57_E0.199261.176
73_R84_M0.198541.171
51_I54_L0.194111.145
29_G32_Y0.193261.140
47_L50_E0.188091.110
40_L44_L0.186441.100
64_E87_P0.186151.098
63_L73_R0.183731.084
60_R70_S0.183541.083
31_V41_F0.180841.067
42_Y65_I0.179681.060
85_V88_E0.178341.052
36_Q43_E0.176251.040
55_Q92_I0.175761.037
52_D55_Q0.174771.031
63_L66_A0.17331.022
45_Q48_E0.171831.014
64_E68_L0.171421.011
39_Q43_E0.165960.979
26_S37_S0.165920.979
37_S65_I0.163480.964
80_E83_G0.163420.964
79_R88_E0.162330.958
55_Q58_N0.161840.955
68_L77_I0.155460.917
74_I82_L0.155340.916
38_R67_T0.153870.908
50_E62_R0.153520.906
28_L59_E0.151190.892
46_Q56_E0.151010.891
24_L86_P0.150160.886
74_I77_I0.150030.885
63_L84_M0.14860.877
74_I78_A0.148030.873
22_V26_S0.146370.864
60_R66_A0.14560.859
25_I83_G0.144670.853
32_Y36_Q0.142960.843
20_V31_V0.142750.842
61_L64_E0.141890.837
74_I84_M0.140940.831
68_L71_P0.140690.830
35_H38_R0.14020.827
41_F47_L0.140070.826
24_L64_E0.139820.825
29_G33_S0.139770.825
60_R67_T0.139690.824
25_I33_S0.138260.816
53_Q57_E0.137340.810
45_Q67_T0.137020.808
30_V44_L0.136970.808
52_D59_E0.136280.804
18_L43_E0.134650.794
48_E52_D0.133930.790
20_V24_L0.133870.790
20_V42_Y0.133840.790
34_R51_I0.132510.782
66_A73_R0.132210.780
49_K53_Q0.132180.780
65_I69_S0.132150.780
38_R84_M0.131950.778
43_E49_K0.131820.778
20_V46_Q0.131540.776
48_E67_T0.131490.776
70_S92_I0.131450.775
27_A35_H0.13090.772
41_F44_L0.130840.772
38_R41_F0.130560.770
36_Q54_L0.128120.756
69_S73_R0.127610.753
28_L51_I0.127060.750
21_I32_Y0.126830.748
22_V41_F0.126460.746
43_E81_K0.126060.744
18_L68_L0.125410.740
47_L51_I0.125040.738
60_R92_I0.123070.726
74_I86_P0.121890.719
71_P74_I0.121530.717
50_E76_R0.121330.716
79_R89_P0.121290.716
36_Q39_Q0.121190.715
46_Q76_R0.120670.712
75_E80_E0.120360.710
78_A84_M0.120120.709
46_Q85_V0.119010.702
86_P92_I0.118680.700
20_V28_L0.117940.696
71_P77_I0.117640.694
37_S69_S0.117520.693
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4dznA0.340282.70.805
4etpA0.6701650.83
1dipA0.7216590.836
3u06A0.670150.70.844
2j5uA0.762946.50.847
4iffA0.670138.50.854
3swkA0.56731.50.86
1a93B0.350530.80.861
4i5sA0.958822.30.87
3ra3B0.288721.30.871
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