GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF692 - Protein of unknown function (DUF692)
Pfam: PF05114 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0036
Length: 274
Sequences: 5768
Seq/Len: 21.05
HH_delta: 0.353 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
48_E52_E0.871913.366
167_G199_V0.851823.289
28_F241_P0.784523.029
134_P167_G0.725192.800
205_G223_P0.679322.623
191_D236_R0.660582.550
136_L199_V0.651992.517
49_A53_R0.630022.432
134_P199_V0.593622.292
19_A54_Y0.585992.262
81_A131_L0.569722.200
84_D131_L0.544512.102
185_D188_E0.532082.054
191_D233_V0.520832.011
232_E236_R0.508291.962
90_W136_L0.504191.947
233_V236_R0.491711.898
83_A88_P0.484391.870
136_L169_L0.48221.862
46_Q49_A0.476361.839
167_G197_R0.475611.836
19_A23_R0.474731.833
44_R85_R0.474481.832
77_R81_A0.471141.819
43_P46_Q0.463251.789
73_K77_R0.455341.758
115_E118_D0.450661.740
156_F160_L0.424741.640
50_I53_R0.418281.615
155_E159_E0.417161.611
188_E191_D0.408581.578
48_E85_R0.402831.555
83_A91_V0.395831.528
117_L160_L0.39111.510
119_H122_D0.382531.477
201_I234_L0.38231.476
69_D73_K0.379471.465
121_V160_L0.370791.432
188_E192_A0.365621.412
50_I54_Y0.36421.406
170_L175_L0.363731.404
205_G225_E0.363461.403
26_V244_L0.362481.400
125_R166_C0.358911.386
129_D164_T0.358611.385
114_E118_D0.356291.376
21_A26_V0.35281.362
78_R81_A0.349151.348
187_Y229_L0.348341.345
152_S192_A0.347241.341
195_L198_V0.342641.323
155_E192_A0.341411.318
171_D245_E0.337551.303
45_E49_A0.33521.294
190_L237_F0.333981.289
20_H23_R0.332631.284
84_D132_G0.331941.282
129_D165_G0.331131.278
30_E200_E0.32921.271
90_W134_P0.328231.267
127_V131_L0.324251.252
74_D78_R0.323621.249
228_D232_E0.323361.248
74_D77_R0.322311.244
118_D160_L0.321911.243
19_A50_I0.321421.241
118_D122_D0.318891.231
72_D123_R0.315991.220
80_K131_L0.315811.219
117_L156_F0.314431.214
173_N204_A0.313721.211
119_H123_R0.313291.210
132_G165_G0.311941.204
139_N175_L0.307971.189
207_S219_S0.3071.185
49_A52_E0.30451.176
138_E245_E0.303511.172
174_N204_A0.30291.169
172_I230_L0.30251.168
21_A29_L0.302021.166
204_A247_D0.29961.157
73_K126_R0.299021.155
115_E119_H0.296891.146
92_S169_L0.296511.145
51_R56_V0.295611.141
203_L227_W0.295431.141
187_Y191_D0.295171.140
70_P74_D0.291471.125
222_V225_E0.290461.121
45_E85_R0.288831.115
125_R129_D0.287751.111
84_D133_R0.286291.105
81_A127_V0.285381.102
19_A53_R0.285261.101
160_L164_T0.285181.101
229_L233_V0.284331.098
90_W199_V0.284171.097
149_S153_E0.283591.095
138_E202_H0.282711.092
139_N154_P0.282141.089
18_L50_I0.280771.084
20_H24_P0.279461.079
202_H245_E0.274511.060
44_R86_L0.274461.060
18_L54_Y0.274251.059
22_E55_P0.274151.058
46_Q50_I0.274041.058
51_R58_L0.27381.057
156_F159_E0.26881.038
126_R163_R0.258320.997
171_D202_H0.257710.995
154_P158_R0.257480.994
231_E235_R0.257420.994
195_L237_F0.256710.991
22_E27_D0.256590.991
126_R129_D0.255810.988
45_E52_E0.255540.987
121_V125_R0.254790.984
128_Q135_L0.252010.973
175_L189_Y0.25180.972
233_V237_F0.250050.965
73_K123_R0.247880.957
67_S71_L0.246130.950
48_E51_R0.245150.947
204_A218_H0.24320.939
76_L80_K0.243090.939
92_S136_L0.241810.934
158_R161_V0.240680.929
150_E153_E0.240090.927
22_E54_Y0.236330.912
140_P247_D0.234250.904
129_D163_R0.233060.900
70_P73_K0.232980.900
31_V56_V0.23280.899
229_L232_E0.232030.896
173_N206_H0.231950.896
77_R80_K0.231050.892
92_S174_N0.229660.887
187_Y232_E0.22880.883
170_L189_Y0.228270.881
152_S156_F0.227250.877
19_A22_E0.227230.877
155_E193_L0.226610.875
134_P165_G0.226160.873
174_N206_H0.226040.873
201_I242_T0.225480.871
30_E243_L0.224480.867
48_E87_N0.224440.867
234_L239_P0.224270.866
195_L233_V0.224120.865
58_L88_P0.222760.860
140_P204_A0.222450.859
80_K127_V0.222240.858
121_V163_R0.220890.853
125_R165_G0.22010.850
141_S177_V0.217820.841
28_F57_S0.215680.833
125_R161_V0.214970.830
113_T116_A0.214810.829
176_Y186_P0.213920.826
31_V58_L0.21330.824
89_P132_G0.213230.823
89_P134_P0.211480.817
81_A84_D0.211270.816
158_R162_E0.210020.811
158_R197_R0.209470.809
92_S202_H0.208840.806
113_T153_E0.207510.801
30_E202_H0.207310.800
122_D125_R0.205790.795
159_E163_R0.204920.791
190_L233_V0.203080.784
152_S155_E0.201840.779
162_E197_R0.201830.779
71_L74_D0.200760.775
169_L174_N0.199190.769
190_L198_V0.198970.768
81_A85_R0.198870.768
77_R127_V0.198250.765
232_E235_R0.198180.765
138_E174_N0.197790.764
59_H94_H0.197640.763
141_S173_N0.197310.762
57_S241_P0.196860.760
157_L161_V0.196380.758
191_D237_F0.196040.757
18_L29_L0.195890.756
47_L50_I0.195730.756
80_K130_A0.195250.754
123_R127_V0.194070.749
75_Y78_R0.193160.746
72_D119_H0.1930.745
159_E162_E0.19270.744
235_R242_T0.19250.743
18_L51_R0.192240.742
227_W231_E0.19180.741
48_E86_L0.191240.738
93_E135_L0.190510.736
203_L242_T0.190090.734
122_D126_R0.189820.733
30_E245_E0.189210.731
44_R48_E0.189010.730
136_L167_G0.18830.727
231_E242_T0.187860.725
121_V161_V0.187470.724
90_W200_E0.186690.721
169_L200_E0.186470.720
200_E243_L0.186110.719
92_S140_P0.185450.716
94_H170_L0.185150.715
170_L198_V0.184580.713
155_E197_R0.183620.709
55_P89_P0.183550.709
220_A224_E0.182520.705
170_L190_L0.18210.703
117_L153_E0.181020.699
140_P174_N0.180410.697
158_R168_L0.180130.695
125_R163_R0.179680.694
83_A133_R0.179270.692
186_P225_E0.178520.689
141_S206_H0.178410.689
80_K128_Q0.178030.687
158_R166_C0.177610.686
57_S89_P0.177220.684
178_N184_F0.176660.682
172_I203_L0.176160.680
141_S174_N0.175660.678
51_R54_Y0.174450.674
32_H174_N0.17370.671
139_N168_L0.173360.669
60_G202_H0.173060.668
171_D204_A0.172980.668
192_A196_E0.172760.667
41_G44_R0.171850.664
117_L121_V0.171380.662
158_R192_A0.169990.656
69_D101_G0.169790.656
187_Y233_V0.169530.655
140_P144_L0.169460.654
168_L193_L0.168990.652
69_D72_D0.168930.652
140_P246_R0.168530.651
176_Y226_V0.168360.650
124_I135_L0.168190.649
138_E171_D0.167590.647
128_Q165_G0.16670.644
28_F243_L0.166240.642
22_E56_V0.165970.641
91_V133_R0.164490.635
40_G43_P0.164490.635
200_E241_P0.164220.634
139_N174_N0.164210.634
126_R130_A0.163690.632
125_R162_E0.163690.632
123_R126_R0.163060.630
77_R130_A0.163020.629
122_D163_R0.162590.628
118_D121_V0.162370.627
94_H204_A0.1620.625
27_D228_D0.161870.625
94_H243_L0.161470.623
124_I137_L0.158970.614
27_D55_P0.158420.612
94_H139_N0.158340.611
157_L160_L0.158020.610
191_D195_L0.157630.609
65_L76_L0.15750.608
168_L198_V0.15730.607
72_D75_Y0.157240.607
142_S178_N0.157230.607
51_R55_P0.157210.607
87_N133_R0.156890.606
114_E150_E0.156690.605
153_E156_F0.156570.605
203_L244_L0.155940.602
45_E48_E0.155920.602
72_D76_L0.155660.601
201_I239_P0.154120.595
198_V237_F0.153840.594
237_F240_R0.152950.591
18_L56_V0.152660.589
193_L196_E0.152550.589
22_E25_A0.152440.589
42_R46_Q0.152360.588
114_E159_E0.152210.588
59_H241_P0.152150.587
140_P143_Y0.151980.587
191_D232_E0.151470.585
155_E158_R0.151410.585
173_N176_Y0.151360.584
92_S200_E0.151320.584
44_R82_L0.151050.583
32_H35_N0.150370.581
186_P189_Y0.150360.581
143_Y177_V0.14970.578
82_L86_L0.149540.577
64_S67_S0.148890.575
154_P168_L0.148730.574
230_L234_L0.148730.574
206_H246_R0.148090.572
59_H218_H0.1470.568
23_R53_R0.146830.567
98_S157_L0.14660.566
153_E157_L0.146420.565
175_L184_F0.146410.565
60_G79_L0.146160.564
204_A246_R0.146070.564
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3kwsA0.90511000.353
1i60A0.94891000.356
3dx5A0.93431000.368
2qulA0.90511000.371
3u0hA0.94531000.372
3vniA0.9271000.374
3bwwA0.99641000.375
2qw5A0.9271000.375
3tvaA0.91971000.379
3qxbA0.94161000.381

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