GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
S6PP - Sucrose-6F-phosphate phosphohydrolase
Pfam: PF05116 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0137
Length: 247
Sequences: 7460
Seq/Len: 30.2
HH_delta: 0.225 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
186_V200_G1.217283.798
197_L203_G1.169653.649
3_R183_Q1.094913.416
42_T49_V1.033023.223
7_S38_F0.992523.096
15_D19_E0.957332.987
174_M184_V0.938042.926
6_A170_L0.876342.734
171_R199_G0.799072.493
165_S195_E0.792012.471
186_V196_M0.761052.374
172_Y175_E0.751952.346
181_P199_G0.733462.288
180_P183_Q0.726792.267
191_G212_E0.704312.197
4_L39_V0.703042.193
22_A26_E0.692982.162
191_G210_Q0.681472.126
7_S187_A0.675382.107
6_A41_V0.66952.089
9_L14_I0.637961.990
25_E55_E0.633451.976
24_L27_L0.623431.945
171_R175_E0.619451.933
65_I169_A0.599861.871
168_A171_R0.582951.819
186_V197_L0.581741.815
167_G199_G0.572851.787
172_Y176_R0.57121.782
205_V209_A0.559491.745
37_L177_W0.549971.716
4_L174_M0.535061.669
42_T66_T0.534421.667
174_M181_P0.534091.666
39_V173_L0.527241.645
21_L24_L0.525051.638
24_L28_L0.521741.628
23_R27_L0.516881.613
39_V63_Y0.515011.607
200_G203_G0.50531.576
25_E29_E0.49321.539
31_Q36_I0.492741.537
170_L196_M0.483741.509
194_L198_E0.46081.438
4_L179_I0.455831.422
185_L204_V0.451041.407
36_I185_L0.448861.400
165_S168_A0.448471.399
70_T161_P0.438721.369
5_L36_I0.436261.361
137_R141_R0.435531.359
15_D18_D0.430681.344
182_E201_D0.426291.330
161_P164_A0.424281.324
49_V64_I0.422751.319
181_P184_V0.422591.318
167_G195_E0.42041.312
28_L38_F0.416421.299
135_E138_A0.410191.280
174_M179_I0.409821.279
9_L52_L0.408081.273
134_E138_A0.405561.265
70_T164_A0.396511.237
148_N195_E0.392681.225
45_S67_S0.389021.214
173_L177_W0.388751.213
63_Y177_W0.387961.210
6_A39_V0.386741.207
134_E137_R0.384571.200
174_M199_G0.376771.175
72_I172_Y0.371471.159
4_L184_V0.36941.152
5_L31_Q0.366541.144
190_S210_Q0.366211.142
6_A184_V0.36561.141
67_S71_E0.364191.136
148_N163_G0.36411.136
170_L186_V0.363671.135
72_I169_A0.363341.134
66_T71_E0.357981.117
29_E33_R0.356631.113
174_M201_D0.353481.103
160_L165_S0.350341.093
41_V65_I0.348141.086
20_A24_L0.344781.076
22_A25_E0.341841.066
26_E29_E0.334811.045
31_Q38_F0.334471.043
138_A141_R0.332981.039
40_Y49_V0.331491.034
9_L49_V0.331451.034
133_L137_R0.330781.032
184_V200_G0.329571.028
5_L185_L0.321591.003
46_L66_T0.321541.003
66_T73_Y0.319460.997
150_I160_L0.314710.982
40_Y53_L0.3130.976
135_E139_R0.311370.971
185_L202_H0.303720.948
9_L40_Y0.30330.946
45_S48_S0.303020.945
8_D189_D0.301990.942
170_L200_G0.300820.938
13_L24_L0.300450.937
184_V199_G0.299620.935
23_R26_E0.298840.932
80_P83_E0.294780.920
191_G194_L0.293440.915
146_R162_K0.293430.915
50_L54_R0.290120.905
4_L173_L0.288380.900
5_L187_A0.285520.891
68_V158_D0.282910.883
68_V192_N0.282430.881
206_V209_A0.281130.877
43_G192_N0.279830.873
160_L195_E0.277860.867
86_A89_D0.277490.866
171_R181_P0.275650.860
179_I184_V0.275270.859
149_V157_L0.275140.858
12_T192_N0.274810.857
95_E98_E0.27420.855
15_D21_L0.272880.851
101_L104_L0.272830.851
53_L64_I0.272590.850
7_S13_L0.270740.845
29_E57_N0.268580.838
84_W87_H0.268030.836
184_V201_D0.266720.832
99_E102_A0.266590.832
49_V66_T0.266340.831
36_I183_Q0.264510.825
152_S156_D0.264330.825
41_V196_M0.264250.824
168_A172_Y0.263130.821
11_G206_V0.262950.820
31_Q35_E0.262490.819
138_A142_Q0.261980.817
6_A173_L0.261680.816
189_D209_A0.261380.815
37_L63_Y0.261330.815
31_Q34_P0.261320.815
46_L73_Y0.260660.813
24_L187_A0.260470.813
124_V128_D0.260460.813
181_P201_D0.260220.812
96_R99_E0.259030.808
121_S124_V0.258130.805
167_G171_R0.257760.804
187_A202_H0.257620.804
163_G168_A0.256330.800
63_Y173_L0.255340.797
3_R36_I0.254880.795
67_S156_D0.254450.794
119_K158_D0.253080.790
67_S158_D0.251270.784
41_V186_V0.25060.782
171_R174_M0.249950.780
164_A168_A0.249240.778
187_A204_V0.249130.777
159_I162_K0.248830.776
102_A106_G0.248730.776
186_V203_G0.248610.776
72_I173_L0.24730.772
148_N165_S0.245430.766
63_Y74_Y0.244960.764
148_N162_K0.244580.763
99_E103_E0.243880.761
20_A25_E0.242660.757
160_L164_A0.238970.746
23_R28_L0.238420.744
13_L20_A0.237320.740
48_S67_S0.23670.738
179_I182_E0.235790.736
197_L205_V0.234660.732
98_E102_A0.233270.728
12_T189_D0.233080.727
49_V53_L0.232690.726
9_L13_L0.232620.726
156_D190_S0.232030.724
103_E106_G0.231760.723
179_I183_Q0.229860.717
100_I103_E0.229830.717
65_I173_L0.229520.716
46_L50_L0.228130.712
32_A38_F0.227820.711
7_S40_Y0.227780.711
11_G153_N0.226830.708
25_E28_L0.226090.705
153_N190_S0.224690.701
65_I69_G0.224020.699
202_H205_V0.223530.697
151_Y154_G0.222140.693
48_S156_D0.221220.690
41_V68_V0.220390.688
42_T64_I0.220190.687
27_L31_Q0.219540.685
13_L40_Y0.219420.685
42_T48_S0.219210.684
9_L18_D0.218970.683
153_N156_D0.216990.677
199_G203_G0.21670.676
149_V159_I0.216630.676
118_F122_Y0.216260.675
40_Y56_Y0.21520.671
150_I154_G0.214950.671
43_G167_G0.214290.669
97_V101_L0.214220.668
204_V207_G0.213910.667
186_V201_D0.213550.666
125_D128_D0.212670.663
10_D44_R0.212230.662
13_L38_F0.212140.662
142_Q145_L0.212030.661
105_P109_P0.211870.661
80_P87_H0.211240.659
168_A195_E0.210990.658
176_R180_P0.21060.657
67_S70_T0.21050.657
183_Q201_D0.210150.656
151_Y156_D0.20910.652
49_V52_L0.208890.652
8_D12_T0.208140.649
205_V208_N0.207230.647
166_K193_D0.207090.646
140_L159_I0.206210.643
45_S190_S0.205360.641
7_S31_Q0.204770.639
95_E99_E0.204270.637
29_E32_A0.204080.637
94_R98_E0.20370.635
4_L37_L0.203080.634
41_V195_E0.202130.631
42_T153_N0.200860.627
185_L201_D0.200370.625
119_K123_Y0.199950.624
122_Y136_I0.199820.623
9_L24_L0.199370.622
12_T166_K0.197830.617
121_S158_D0.196840.614
43_G158_D0.196420.613
104_L107_L0.1960.611
115_Q118_F0.195990.611
90_E93_D0.195920.611
47_E50_L0.194740.608
194_L197_L0.194460.607
65_I72_I0.19380.605
43_G46_L0.193420.603
79_Q82_E0.193180.603
38_F204_V0.192510.601
72_I176_R0.192240.600
11_G190_S0.191670.598
118_F121_S0.191610.598
4_L177_W0.190630.595
151_Y155_R0.190140.593
79_Q87_H0.189850.592
67_S121_S0.189540.591
93_D97_V0.189450.591
101_L105_P0.189430.591
101_L109_P0.188730.589
37_L179_I0.188530.588
80_P85_Q0.187940.586
174_M178_G0.187380.585
51_R55_E0.187210.584
167_G197_L0.186940.583
128_D135_E0.186440.582
143_R147_V0.18640.582
149_V152_S0.186160.581
144_G162_K0.18570.579
48_S51_R0.185550.579
173_L176_R0.185070.577
167_G170_L0.184840.577
122_Y125_D0.184160.575
116_R120_I0.183570.573
99_E106_G0.182910.571
136_I140_L0.182910.571
120_I125_D0.182490.569
51_R54_R0.182180.568
38_F58_L0.180840.564
119_K125_D0.180630.564
85_Q88_I0.180590.563
97_V100_I0.180460.563
86_A90_E0.180390.563
81_D84_W0.180220.562
109_P115_Q0.179880.561
47_E51_R0.179650.560
86_A91_R0.179170.559
166_K189_D0.179140.559
82_E86_A0.178990.558
189_D193_D0.178740.558
88_I91_R0.178590.557
95_E103_E0.177920.555
119_K122_Y0.177170.553
39_V65_I0.176950.552
183_Q202_H0.176870.552
14_I48_S0.176330.550
82_E87_H0.175590.548
143_R146_R0.175280.547
74_Y176_R0.175270.547
133_L151_Y0.175250.547
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1s2oA0.94741000.225
3pgvA0.92311000.237
3daoA0.90691000.239
3mpoA0.9191000.253
3dnpA0.90691000.26
3l7yA0.90691000.262
4dw8A0.9151000.262
3fzqA0.89071000.276
3r4cA0.88261000.279
2pq0A0.88661000.282

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