GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF697 - Domain of unknown function (DUF697)
Pfam: PF05128 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 162
Sequences: 1052
Seq/Len: 6.49
HH_delta: 0.763 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
26_I132_I0.359773.194
61_I135_F0.281332.498
54_Q124_T0.278642.474
26_I128_G0.245772.182
37_V120_A0.242022.149
25_I64_I0.239722.128
23_N132_I0.238352.116
22_A65_Y0.225752.004
65_Y136_E0.219971.953
25_I57_M0.212191.884
56_K60_E0.203911.810
100_K103_K0.19141.699
61_I64_I0.188991.678
13_E17_Q0.178491.585
57_M124_T0.178021.581
26_I61_I0.17691.571
22_A61_I0.173521.541
19_D136_E0.169521.505
38_A117_A0.163921.455
105_S108_G0.160951.429
34_A42_I0.160091.421
106_L109_T0.156211.387
19_D132_I0.152371.353
37_V41_P0.149441.327
41_P120_A0.147561.310
41_P44_F0.146981.305
89_G123_L0.142521.265
62_A135_F0.137671.222
121_G125_Y0.136681.213
19_D65_Y0.129651.151
49_A53_I0.129471.149
94_G98_V0.129291.148
87_G90_A0.129081.146
55_A76_E0.128941.145
24_R28_R0.127631.133
32_L53_I0.126851.126
30_A34_A0.126821.126
92_E95_A0.125911.118
23_N129_K0.125451.114
22_A132_I0.125121.111
125_Y129_K0.122271.086
109_T112_G0.122181.085
57_M83_S0.122091.084
99_G102_L0.121791.081
39_A86_A0.119751.063
32_L35_G0.119431.060
38_A113_A0.11921.058
57_M128_G0.11711.040
26_I57_M0.116971.038
24_R27_K0.116911.038
58_I131_A0.116211.032
22_A64_I0.115741.028
30_A128_G0.115611.026
61_I132_I0.114511.017
12_Q93_L0.114031.012
42_I103_K0.114021.012
107_A115_I0.11341.007
119_S123_L0.113331.006
107_A114_A0.113231.005
47_A96_S0.112540.999
115_I118_A0.112210.996
33_A53_I0.112090.995
56_K120_A0.11070.983
84_G126_A0.109770.975
29_Y60_E0.109730.974
40_S50_L0.109660.974
72_A75_K0.109270.970
58_I81_L0.109190.969
39_A105_S0.107160.951
50_L124_T0.106740.948
12_Q63_K0.106720.947
35_G96_S0.10530.935
17_Q33_A0.103950.923
25_I60_E0.103580.920
116_Q120_A0.10350.919
34_A128_G0.103010.915
65_Y131_A0.102930.914
40_S92_E0.102830.913
108_G112_G0.102830.913
37_V131_A0.102640.911
110_V114_A0.10220.907
109_T116_Q0.102040.906
58_I115_I0.101740.903
99_G110_V0.101590.902
57_M64_I0.100520.892
46_D88_Q0.100080.889
46_D120_A0.099930.887
55_A74_A0.099830.886
62_A131_A0.099690.885
37_V40_S0.099560.884
48_A52_A0.099310.882
24_R31_W0.099290.882
129_K132_I0.099190.881
37_V48_A0.099150.880
18_R136_E0.098760.877
47_A95_A0.098740.877
12_Q20_Q0.098730.877
53_I73_G0.098370.873
81_L91_V0.098140.871
86_A132_I0.098020.870
52_A56_K0.097690.867
85_L102_L0.097330.864
37_V53_I0.097050.862
98_V102_L0.096720.859
93_L97_L0.096710.859
53_I92_E0.096110.853
19_D22_A0.095850.851
16_E20_Q0.095780.850
17_Q20_Q0.095770.850
71_Q82_G0.09560.849
33_A129_K0.095180.845
85_L107_A0.094830.842
109_T113_A0.094420.838
14_L55_A0.093770.833
38_A46_D0.093620.831
40_S45_L0.093560.831
107_A112_G0.093430.830
31_W60_E0.093160.827
34_A41_P0.092830.824
67_L82_G0.092680.823
58_I127_I0.091580.813
131_A135_F0.091430.812
16_E118_A0.091410.812
62_A78_I0.09120.810
55_A82_G0.091120.809
24_R94_G0.091060.808
19_D111_S0.0910.808
73_G128_G0.090950.807
55_A59_R0.090870.807
45_L66_G0.090580.804
37_V116_Q0.090330.802
59_R74_A0.09020.801
22_A131_A0.09010.800
15_L38_A0.090020.799
36_A103_K0.089750.797
62_A129_K0.089540.795
58_I102_L0.089430.794
36_A109_T0.089410.794
21_R44_F0.089260.792
47_A72_A0.088950.790
43_P86_A0.088880.789
26_I70_S0.088450.785
31_W35_G0.088380.785
132_I136_E0.088280.784
114_A128_G0.087940.781
82_G139_P0.087620.778
79_S82_G0.087580.778
23_N27_K0.087310.775
12_Q61_I0.087160.774
121_G130_A0.087010.773
13_E99_G0.08690.772
21_R25_I0.086790.771
43_P80_S0.086620.769
83_S86_A0.086430.767
37_V69_P0.086060.764
23_N26_I0.0860.764
122_A126_A0.085840.762
114_A133_E0.085660.761
49_A119_S0.085550.760
105_S110_V0.085520.759
117_A122_A0.085260.757
67_L135_F0.085230.757
38_A51_L0.084650.752
105_S109_T0.084460.750
50_L95_A0.084430.750
76_E101_L0.084330.749
88_Q91_V0.084080.746
51_L77_L0.083930.745
20_Q133_E0.083790.744
16_E63_K0.083750.744
76_E104_S0.083520.742
84_G124_T0.083440.741
91_V115_I0.083210.739
21_R45_L0.083130.738
55_A118_A0.082810.735
18_R64_I0.082780.735
12_Q17_Q0.08260.733
17_Q130_A0.082480.732
90_A110_V0.082310.731
50_L120_A0.082150.729
84_G119_S0.082080.729
58_I62_A0.081310.722
110_V129_K0.081310.722
33_A54_Q0.081130.720
110_V125_Y0.081080.720
28_R125_Y0.080890.718
135_F138_G0.080860.718
16_E50_L0.080780.717
94_G101_L0.080510.715
87_G96_S0.080510.715
111_S121_G0.080490.715
30_A121_G0.080340.713
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1tq4A0.901297.70.763
1czaN0.870438.80.907
4ay3A0.703717.70.921
3v7iA0.740714.20.924
3vs8A0.7469140.924
4b4kA0.6914110.927
3k7aM0.9639.40.929
1hr6B0.33339.10.93
3hl2A0.95688.20.931
1aisB0.96917.90.932
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