GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
TRIC - TRIC channel
Pfam: PF05197 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 197
Sequences: 1182
Seq/Len: 6
HH_delta: 0.964 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
22_S58_W0.331652.462
157_A184_L0.323262.399
21_S134_R0.315072.339
190_S194_L0.305282.266
185_V189_L0.305142.265
31_I44_P0.295552.194
103_K112_M0.286292.125
94_I189_L0.277962.063
98_V185_V0.271342.014
39_E105_Y0.267631.986
100_H120_G0.258661.920
16_L151_T0.256531.904
24_L133_L0.253161.879
93_K192_M0.252021.871
160_L183_F0.250991.863
31_I122_G0.245141.820
140_E146_K0.244431.814
101_A185_V0.227771.691
100_H154_C0.219771.631
125_F133_L0.217151.612
190_S196_S0.213641.586
156_L187_F0.20611.530
97_G185_V0.205681.527
19_W58_W0.204441.517
117_T155_L0.200731.490
27_F54_A0.198831.476
48_N52_L0.198321.472
21_S135_G0.191371.420
23_M54_A0.189731.408
16_L20_L0.189071.403
149_F153_A0.186911.387
142_N145_L0.183441.362
26_C54_A0.183131.359
115_I120_G0.180441.339
22_S54_A0.177481.317
112_M162_T0.173971.291
163_L169_L0.173661.289
44_P122_G0.17191.276
101_A184_L0.171681.274
191_M196_S0.171111.270
37_L111_V0.168391.250
31_I43_A0.168311.249
23_M51_V0.166531.236
181_T185_V0.16651.236
134_R140_E0.166321.234
44_P111_V0.163331.212
57_I61_I0.163311.212
113_I162_T0.160091.188
112_M116_G0.15841.176
32_L118_V0.158161.174
176_L180_Y0.157241.167
133_L145_L0.156771.164
101_A181_T0.152511.132
113_I155_L0.151291.123
163_L168_Y0.149691.111
101_A157_A0.149571.110
17_A21_S0.148681.104
30_G96_S0.147561.095
116_G180_Y0.146421.087
144_L186_Y0.146371.086
97_G189_L0.145131.077
113_I159_I0.14441.072
154_C158_S0.143831.068
52_L56_A0.142081.055
182_V186_Y0.141961.054
178_F182_V0.141491.050
37_L107_N0.141491.050
100_H144_L0.140551.043
161_F180_Y0.137591.021
25_M28_G0.13631.012
111_V115_I0.135651.007
129_F133_L0.134981.002
20_L151_T0.134971.002
164_Q171_I0.134831.001
33_S128_P0.134190.996
17_A151_T0.133060.988
17_A142_N0.132950.987
33_S96_S0.132360.982
43_A115_I0.132050.980
104_L175_Q0.131350.975
109_W113_I0.13120.974
124_G142_N0.131010.972
18_S62_F0.130940.972
14_H102_L0.130290.967
32_L122_G0.130280.967
45_L111_V0.130260.967
159_I196_S0.130040.965
125_F145_L0.129780.963
123_G128_P0.129710.963
23_M122_G0.129630.962
96_S128_P0.128910.957
31_I42_L0.128730.955
107_N111_V0.128590.954
42_L152_K0.12840.953
114_L118_V0.12810.951
115_I119_K0.12810.951
175_Q179_L0.127080.943
168_Y182_V0.126330.938
30_G123_G0.125490.931
121_A144_L0.125280.930
99_D124_G0.125120.929
94_I192_M0.125080.928
116_G140_E0.124380.923
15_P62_F0.123930.920
160_L179_L0.123720.918
24_L126_M0.123580.917
14_H142_N0.122820.912
107_N158_S0.122510.909
168_Y172_S0.120250.893
143_E148_S0.119580.888
153_A187_F0.119460.887
19_W55_T0.118710.881
128_P150_P0.118590.880
54_A62_F0.117920.875
155_L159_I0.117070.869
124_G150_P0.116680.866
58_W65_P0.116340.864
172_S175_Q0.115510.857
183_F186_Y0.115090.854
163_L182_V0.114610.851
190_S195_G0.114270.848
33_S127_K0.113660.844
33_S150_P0.113540.843
27_F43_A0.113530.843
169_L172_S0.113160.840
13_K140_E0.11260.836
54_A162_T0.112310.834
93_K97_G0.112290.833
30_G99_D0.112150.832
168_Y174_H0.111880.830
58_W62_F0.111660.829
14_H124_G0.111620.828
99_D188_K0.111420.827
26_C30_G0.111250.826
153_A157_A0.110980.824
32_L144_L0.110540.820
112_M115_I0.110520.820
43_A50_D0.110290.819
171_I179_L0.11020.818
51_V110_I0.110090.817
96_S150_P0.110070.817
38_G148_S0.109760.815
47_N53_L0.109330.811
60_L84_A0.109240.811
97_G101_A0.109040.809
36_L45_L0.108690.807
101_A112_M0.108680.807
110_I113_I0.108190.803
33_S119_K0.108030.802
135_G140_E0.107820.800
33_S123_G0.107760.800
178_F186_Y0.107470.798
12_R22_S0.106350.789
43_A119_K0.10630.789
35_L60_L0.105730.785
28_G123_G0.105720.785
107_N112_M0.105490.783
34_N128_P0.105450.783
163_L172_S0.10540.782
55_T58_W0.105360.782
96_S123_G0.105260.781
91_A182_V0.104770.778
56_A106_P0.104530.776
120_G184_L0.104290.774
135_G163_L0.103880.771
34_N96_S0.103760.770
36_L108_S0.10350.768
135_G144_L0.103210.766
164_Q176_L0.103090.765
65_P85_M0.103060.765
46_A50_D0.102980.764
14_H150_P0.10270.762
183_F187_F0.10260.762
153_A156_L0.102520.761
108_S115_I0.102290.759
41_P100_H0.102180.758
30_G119_K0.102140.758
26_C151_T0.101730.755
96_S124_G0.101260.752
95_L190_S0.100970.749
64_C89_S0.100880.749
95_L149_F0.100750.748
165_H168_Y0.100610.747
147_P197_H0.100580.747
45_L95_L0.100570.746
142_N151_T0.100550.746
154_C161_F0.100460.746
28_G44_P0.100450.746
102_L107_N0.100060.743
168_Y171_I0.100040.743
63_Y90_R0.099890.741
58_W158_S0.099820.741
16_L121_A0.099750.740
14_H127_K0.099570.739
117_T121_A0.099460.738
96_S127_K0.099180.736
35_L129_F0.099080.735
19_W23_M0.099070.735
52_L196_S0.098860.734
127_K150_P0.09880.733
156_L189_L0.098760.733
98_V174_H0.09860.732
86_K181_T0.098310.730
59_Y189_L0.098130.728
165_H176_L0.097720.725
38_G149_F0.09770.725
96_S99_D0.097450.723
125_F160_L0.097320.722
91_A160_L0.097120.721
113_I197_H0.097030.720
34_N153_A0.096820.719
171_I175_Q0.096730.718
96_S188_K0.096630.717
97_G112_M0.096490.716
40_P45_L0.096320.715
42_L116_G0.096270.715
123_G150_P0.096250.714
159_I173_P0.096010.713
14_H96_S0.095940.712
60_L160_L0.095890.712
59_Y169_L0.095780.711
45_L115_I0.095720.710
42_L45_L0.095580.709
25_M127_K0.095410.708
100_H142_N0.095280.707
19_W172_S0.095250.707
31_I115_I0.095170.706
53_L152_K0.095170.706
56_A109_W0.095080.706
160_L176_L0.094790.704
116_G162_T0.094630.702
21_S26_C0.094610.702
90_R117_T0.094420.701
27_F50_D0.094220.699
117_T154_C0.093940.697
162_T165_H0.093880.697
35_L40_P0.093850.697
33_S188_K0.093760.696
61_I65_P0.093760.696
20_L24_L0.093470.694
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
1pw4A0.91883.20.964
4apsA0.93430.965
4jr9A0.9341.70.969
4gh4D0.16751.50.97
3uguA0.30461.40.97
2aa4A0.82231.20.971
4g6hA0.36041.20.971
4ijaA0.87821.10.972
4iu9B0.9341.10.972
1mwqA0.172610.973
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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