GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
AXE1 - Acetyl xylan esterase (AXE1)
Pfam: PF05448 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0028
Length: 320
Sequences: 3956
Seq/Len: 12.36
HH_delta: 0.203 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
110_Y318_K0.438322.970
62_E68_R0.420552.849
179_V189_A0.417232.827
173_D176_R0.406362.753
178_G201_A0.405842.750
118_R158_D0.399362.706
61_F162_A0.394352.672
83_L111_A0.391462.652
178_G317_L0.391412.652
73_L113_L0.38752.625
193_A202_A0.348882.364
57_Y75_R0.343642.328
73_L111_A0.336082.277
85_A172_V0.326672.213
60_S68_R0.317922.154
61_F71_G0.314512.131
108_A314_L0.304742.065
71_G113_L0.30432.062
59_V71_G0.298892.025
293_E312_K0.284221.926
165_F169_L0.283341.920
271_L298_P0.277121.878
86_V105_W0.272851.849
76_P111_A0.270261.831
285_Y292_K0.268911.822
265_V288_I0.264811.794
267_F285_Y0.264741.794
271_L296_V0.256481.738
116_D121_G0.251251.702
182_G205_D0.245611.664
91_G183_S0.245471.663
179_V202_A0.24291.646
86_V110_Y0.239781.625
189_A202_A0.239741.624
175_K200_K0.236971.606
53_G77_K0.236411.602
75_R111_A0.232261.574
61_F115_M0.22951.555
64_F161_R0.229081.552
108_A318_K0.224621.522
164_D198_R0.219281.486
203_A317_L0.217911.476
204_A207_P0.216571.467
60_S70_Y0.215681.461
85_A111_A0.213881.449
182_G206_V0.212961.443
295_V312_K0.209111.417
113_L162_A0.208851.415
284_A288_I0.207521.406
282_F296_V0.207081.403
65_D118_R0.201341.364
272_Q299_E0.200751.360
55_E77_K0.199921.355
186_G204_A0.199761.353
269_V281_Q0.197431.338
189_A204_A0.196861.334
268_S297_Y0.196031.328
267_F288_I0.192881.307
89_F159_A0.191541.298
57_Y169_L0.190651.292
90_H117_V0.189781.286
55_E75_R0.188151.275
190_L204_A0.186981.267
163_V199_V0.18671.265
181_G186_G0.185651.258
86_V317_L0.185261.255
104_P108_A0.183611.244
282_F286_N0.182271.235
85_A113_L0.18181.232
311_D315_N0.181581.230
285_Y294_L0.180161.221
58_D70_Y0.179671.217
79_A83_L0.179661.217
92_Y184_Q0.179291.215
74_Y114_A0.179221.214
183_S273_D0.177291.201
59_V165_F0.176331.195
259_R287_A0.176331.195
76_P83_L0.175841.191
269_V278_P0.174951.185
161_R164_D0.174551.183
160_V196_D0.173391.175
60_S123_R0.172311.167
194_A261_I0.1721.165
111_A171_E0.16981.150
179_V199_V0.169561.149
164_D168_S0.167631.136
189_A193_A0.16651.128
157_L195_L0.161991.098
243_P247_E0.161741.096
73_L171_E0.160871.090
257_F260_R0.160761.089
64_F157_L0.159871.083
84_P176_R0.159641.082
268_S295_V0.15921.079
113_L166_L0.158591.075
278_P282_F0.158131.071
269_V294_L0.157851.070
179_V192_A0.157461.067
58_D72_W0.156991.064
79_A111_A0.156111.058
184_Q187_G0.155771.055
160_V164_D0.154691.048
82_K173_D0.15421.045
78_N82_K0.153641.041
207_P276_C0.151981.030
160_V192_A0.151871.029
85_A166_L0.151461.026
282_F294_L0.151261.025
270_G302_H0.149391.012
84_P173_D0.148821.008
155_V184_Q0.14841.005
116_D123_R0.147160.997
111_A172_V0.145910.989
254_A257_F0.145770.988
203_A313_Q0.145340.985
167_R177_I0.145150.983
106_A109_G0.143610.973
59_V169_L0.142730.967
87_V177_I0.142590.966
172_V176_R0.142470.965
75_R171_E0.14120.957
91_G270_G0.140510.952
247_E250_S0.139870.948
167_R172_V0.139570.946
157_L161_R0.139370.944
102_L114_A0.138610.939
165_F168_S0.137090.929
307_E312_K0.136920.928
285_Y290_G0.136680.926
193_A263_C0.136590.925
167_R198_R0.136440.924
87_V115_M0.135760.920
165_F171_E0.135590.919
197_P262_K0.135140.916
267_F281_Q0.134330.910
74_Y106_A0.13410.909
92_Y118_R0.133150.902
269_V282_F0.132850.900
276_C281_Q0.132640.899
71_G162_A0.132510.898
202_A265_V0.132020.894
88_Q180_T0.131810.893
283_A286_N0.131010.888
180_T204_A0.130850.887
119_G184_Q0.130790.886
278_P296_V0.130610.885
89_F115_M0.13020.882
105_W180_T0.129940.880
117_V120_Q0.129640.878
226_P229_R0.129570.878
246_F249_L0.129450.877
164_D196_D0.129260.876
63_S69_V0.128420.870
92_Y121_G0.128260.869
71_G115_M0.128220.869
312_K315_N0.12740.863
116_D120_Q0.127160.862
194_A284_A0.126870.860
92_Y120_Q0.126560.858
103_L107_A0.126070.854
86_V180_T0.126060.854
181_G185_G0.125960.853
156_Y212_F0.125650.851
201_A317_L0.125630.851
90_H120_Q0.125450.850
246_F250_S0.124170.841
187_G190_L0.124060.841
104_P310_E0.123930.840
102_L268_S0.123570.837
93_G122_G0.123290.835
206_V270_G0.122510.830
271_L282_F0.122140.828
92_Y188_L0.121840.826
210_C284_A0.121150.821
251_Y254_A0.120410.816
91_G119_G0.119970.813
81_G84_P0.119760.811
203_A266_L0.119680.811
63_S118_R0.119290.808
87_V159_A0.118810.805
174_G200_K0.118740.805
180_T313_Q0.118270.801
83_L173_D0.118250.801
186_G206_V0.11780.798
201_A264_P0.117750.798
185_G189_A0.117640.797
297_Y312_K0.117490.796
190_L202_A0.117430.796
314_L318_K0.117250.794
267_F284_A0.117110.793
54_V107_A0.117080.793
289_P292_K0.117020.793
180_T205_D0.116840.792
92_Y115_M0.116540.790
233_R237_P0.11630.788
266_L312_K0.116260.788
238_H243_P0.115960.786
92_Y124_S0.115720.784
239_H242_E0.115720.784
156_Y192_A0.115460.782
163_V177_I0.114850.778
186_G267_F0.114750.777
79_A82_K0.114340.775
277_P280_T0.114330.775
85_A177_I0.114260.774
273_D277_P0.114090.773
282_F285_Y0.113550.769
266_L295_V0.113380.768
213_R217_E0.112860.765
206_V304_Y0.112820.764
262_K314_L0.11270.764
117_V188_L0.112660.763
70_Y122_G0.11260.763
310_E314_L0.112580.763
213_R243_P0.11210.760
203_A268_S0.11170.757
61_F69_V0.111370.755
104_P107_A0.110960.752
159_A192_A0.110790.751
120_Q184_Q0.109660.743
92_Y117_V0.108640.736
156_Y191_A0.108590.736
119_G273_D0.108560.736
75_R79_A0.108370.734
250_S256_N0.108090.732
205_D305_G0.107930.731
265_V292_K0.10780.730
87_V162_A0.107730.730
179_V195_L0.107720.730
84_P175_K0.10710.726
112_V288_I0.106430.721
91_G185_G0.106380.721
80_K83_L0.106160.719
56_V72_W0.105640.716
118_R188_L0.105540.715
273_D276_C0.105370.714
171_E174_G0.105190.713
281_Q285_Y0.104890.711
299_E312_K0.104870.711
255_V287_A0.10480.710
223_G229_R0.104550.708
238_H242_E0.10450.708
80_K164_D0.104220.706
53_G107_A0.10420.706
190_L261_I0.10420.706
271_L299_E0.103830.703
106_A111_A0.10380.703
280_T283_A0.103670.702
180_T203_A0.103450.701
223_G226_P0.103440.701
265_V285_Y0.103440.701
80_K262_K0.103130.699
183_S206_V0.103080.698
109_G112_V0.103050.698
209_L212_F0.1030.698
285_Y289_P0.102990.698
184_Q188_L0.102880.697
199_V202_A0.10280.697
91_G186_G0.102490.694
201_A316_F0.102450.694
219_R227_E0.102360.694
243_P246_F0.102290.693
82_K262_K0.102270.693
111_A166_L0.102160.692
82_K174_G0.101980.691
195_L198_R0.101930.691
216_L226_P0.101820.690
215_A220_A0.101660.689
242_E270_G0.101050.685
214_R283_A0.100760.683
194_A263_C0.100580.681
232_F239_H0.100420.680
115_M162_A0.100340.680
187_G191_A0.10.678
73_L163_V0.099650.675
92_Y276_C0.099650.675
250_S254_A0.099490.674
55_E78_N0.099380.673
163_V198_R0.099350.673
91_G273_D0.09930.673
105_W112_V0.099280.673
61_F165_F0.099220.672
182_G275_V0.098690.669
167_R170_P0.098480.667
81_G260_R0.098350.666
156_Y188_L0.098310.666
113_L163_V0.098160.665
70_Y123_R0.098030.664
214_R217_E0.097850.663
160_V195_L0.097840.663
264_P313_Q0.097840.663
87_V113_L0.097440.660
173_D200_K0.097320.659
310_E313_Q0.097310.659
76_P173_D0.097270.659
172_V177_I0.097070.658
168_S260_R0.096970.657
87_V188_L0.096290.652
174_G177_I0.096240.652
86_V315_N0.096190.652
69_V191_A0.096140.651
186_G273_D0.095940.650
220_A228_I0.095610.648
56_V74_Y0.095590.648
89_F179_V0.095470.647
273_D302_H0.095460.647
220_A229_R0.095320.646
54_V77_K0.095260.645
250_S253_D0.09520.645
71_G87_V0.094950.643
226_P230_R0.094880.643
217_E283_A0.094740.642
213_R250_S0.094650.641
194_A257_F0.094450.640
262_K265_V0.094340.639
258_A261_I0.094310.639
159_A188_L0.094130.638
300_Y306_P0.094040.637
69_V312_K0.093850.636
105_W110_Y0.093840.636
69_V166_L0.093760.635
301_G304_Y0.093620.634
215_A281_Q0.093580.634
193_A261_I0.093340.632
69_V115_M0.09330.632
68_R125_P0.093150.631
213_R216_L0.092910.630
178_G200_K0.092680.628
63_S115_M0.09260.627
64_F67_S0.092550.627
167_R174_G0.092440.626
289_P311_D0.092410.626
88_Q182_G0.092270.625
261_I288_I0.092220.625
75_R83_L0.092160.624
93_G120_Q0.092140.624
157_L160_V0.091730.622
70_Y269_V0.091620.621
268_S271_L0.091590.621
206_V300_Y0.091490.620
207_P269_V0.091360.619
266_L316_F0.091340.619
155_V159_A0.091230.618
215_A277_P0.091230.618
59_V113_L0.091190.618
94_G120_Q0.091180.618
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3fcyA0.99381000.203
1vlqA0.98441000.233
1l7aA0.98121000.266
4hvtA0.89691000.43
3g8yA0.951000.44
4a5sA0.89691000.453
4hxfB0.89381000.456
3nuzA0.951000.456
1yr2A0.89381000.46
2ecfA0.89691000.46

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