GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
HR_lesion - HR-like lesion-inducing
Pfam: PF05514 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0131
Length: 138
Sequences: 1090
Seq/Len: 7.9
HH_delta: 0.932 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
104_D107_N0.566283.603
23_K73_K0.377792.404
13_A77_G0.326662.078
17_L77_G0.322422.051
26_E29_D0.29541.879
76_G87_G0.281051.788
117_Q121_M0.268471.708
79_L87_G0.266711.697
105_F122_F0.261971.667
103_Y118_L0.259151.649
69_A73_K0.247551.575
13_A80_F0.241691.538
22_Q25_N0.241581.537
119_L123_L0.234091.489
20_A77_G0.225471.435
21_W74_G0.224021.425
8_G131_A0.213021.355
19_S94_Y0.21231.351
99_T122_F0.209451.333
66_V69_A0.207751.322
27_F67_A0.203591.295
119_L122_F0.202961.291
71_A75_L0.199341.268
23_K94_Y0.196681.251
6_F10_V0.196031.247
101_I104_D0.195931.247
20_A74_G0.195631.245
89_Y93_L0.191611.219
118_L125_N0.191311.217
6_F83_G0.190491.212
76_G81_I0.188661.200
27_F70_I0.18841.199
19_S124_Q0.18711.190
8_G127_A0.185011.177
96_A100_P0.184151.172
92_L96_A0.184041.171
19_S23_K0.183331.166
121_M124_Q0.182461.161
123_L126_L0.182161.159
13_A17_L0.181811.157
128_L131_A0.181711.156
121_M125_N0.178491.136
16_F19_S0.177291.128
23_K26_E0.175861.119
21_W25_N0.171311.090
116_V120_I0.163541.040
8_G134_F0.162531.034
87_G90_L0.161681.029
5_S134_F0.160671.022
121_M128_L0.159041.012
17_L20_A0.157661.003
95_L129_F0.156970.999
23_K69_A0.155350.988
99_T129_F0.155010.986
10_V14_S0.154290.982
68_A82_F0.153370.976
102_L118_L0.152350.969
53_L56_Q0.150980.961
67_A71_A0.149820.953
117_Q120_I0.149770.953
92_L99_T0.148430.944
95_L98_V0.147070.936
98_V102_L0.147050.936
66_V73_K0.146910.935
99_T125_N0.145620.926
11_L130_G0.145550.926
66_V70_I0.145280.924
23_K66_V0.144630.920
23_K70_I0.142560.907
17_L22_Q0.142320.905
27_F31_G0.142290.905
91_L132_L0.142080.904
17_L81_I0.142040.904
18_L21_W0.141510.900
19_S30_D0.140760.896
95_L99_T0.139620.888
78_I82_F0.138280.880
118_L121_M0.13750.875
15_V128_L0.137090.872
98_V101_I0.136210.867
75_L116_V0.135850.864
22_Q26_E0.135230.860
19_S120_I0.134390.855
103_Y106_Y0.13360.850
69_A98_V0.132170.841
73_K94_Y0.132150.841
68_A114_E0.13130.835
7_V10_V0.131180.835
98_V125_N0.130840.832
129_F132_L0.129540.824
24_F70_I0.129230.822
14_S127_A0.128240.816
77_G83_G0.128070.815
97_I104_D0.127450.811
72_L78_I0.127430.811
80_F83_G0.1270.808
12_F24_F0.126910.807
83_G88_A0.12660.805
59_H93_L0.126570.805
74_G117_Q0.125630.799
81_I114_E0.124730.794
9_R77_G0.124160.790
17_L26_E0.123810.788
94_Y98_V0.123370.785
20_A72_L0.122230.778
16_F128_L0.121890.775
86_F90_L0.121490.773
30_D124_Q0.121430.773
31_G65_L0.121040.770
78_I90_L0.120750.768
55_V94_Y0.120650.768
22_Q119_L0.12030.765
103_Y124_Q0.118870.756
95_L102_L0.11840.753
59_H90_L0.118270.752
11_L131_A0.118020.751
120_I124_Q0.117880.750
75_L79_L0.11690.744
100_P104_D0.116850.743
79_L86_F0.116550.742
60_I109_D0.116130.739
92_L131_A0.11590.737
18_L26_E0.115890.737
94_Y132_L0.115420.734
8_G66_V0.114990.732
7_V56_Q0.11490.731
7_V132_L0.114510.729
24_F71_A0.114170.726
21_W84_S0.113680.723
59_H129_F0.113420.722
25_N128_L0.113160.720
23_K102_L0.112930.718
60_I96_A0.112810.718
21_W92_L0.112450.715
85_S108_Y0.111840.712
108_Y114_E0.111590.710
15_V117_Q0.109980.700
60_I92_L0.109630.697
8_G130_G0.109550.697
68_A75_L0.109520.697
65_L69_A0.109460.696
52_K58_P0.109410.696
56_Q60_I0.108650.691
24_F66_V0.108470.690
100_P129_F0.108220.689
27_F98_V0.10790.686
60_I126_L0.10780.686
90_L94_Y0.107770.686
16_F124_Q0.107680.685
56_Q108_Y0.107480.684
118_L122_F0.107440.684
77_G120_I0.10740.683
21_W123_L0.106820.680
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
1zcdA0.5294.10.932
1q90R0.21741.60.944
2k1aA0.19571.60.944
1v54G0.22461.50.945
2jo1A0.22461.30.947
2l8sA0.18841.10.949
1m56C0.65221.10.949
2gutA0.18841.10.949
3v67A0.33331.10.949
2kncA0.21011.10.949
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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