GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF791 - Protein of unknown function (DUF791)
Pfam: PF05631 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0015
Length: 354
Sequences: 28706
Seq/Len: 81.09
HH_delta: 0.371 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
119_S123_V1.873274.244
108_L134_A1.578213.576
122_P126_L1.406693.187
89_V137_L1.358583.078
121_Y125_L1.222572.770
112_S127_G1.221032.766
81_S129_V1.193982.705
120_N123_V1.186362.688
110_S205_L1.133082.567
105_F137_L1.121432.541
67_S70_Q1.120742.539
85_F133_I1.099432.491
238_R242_S1.058872.399
112_S130_L1.041992.361
116_K199_D1.01982.310
99_K103_L1.01522.300
112_S134_A1.007962.284
269_P272_D0.959942.175
90_G94_D0.955662.165
85_F136_S0.946772.145
118_S123_V0.924582.095
307_R310_S0.922352.090
103_L209_A0.902682.045
276_E279_P0.899032.037
103_L213_L0.881241.997
210_V214_K0.87241.977
91_S95_R0.841651.907
77_A129_V0.829221.879
118_S127_G0.812751.841
81_S85_F0.796521.805
107_I209_A0.791731.794
70_Q121_Y0.789011.788
93_A141_A0.762541.728
92_L101_A0.743471.684
112_S131_G0.740331.677
190_F196_A0.735361.666
74_L124_L0.726641.646
110_S209_A0.723551.639
310_S314_Y0.714911.620
66_F70_Q0.708041.604
100_K103_L0.700571.587
152_K155_F0.69761.581
114_L202_I0.681981.545
320_A324_A0.670441.519
77_A125_L0.670151.518
199_D203_V0.660951.497
104_L108_L0.652031.477
92_L96_Y0.645841.463
100_K104_L0.641691.454
105_F134_A0.634951.439
98_R149_E0.6271.421
108_L112_S0.625261.417
309_E313_R0.623441.412
279_P282_L0.616361.396
191_G195_V0.605591.372
97_G100_K0.604521.370
66_F121_Y0.603051.366
85_F88_F0.602711.366
289_V293_L0.588161.333
123_V127_G0.586181.328
211_L215_T0.584831.325
310_S313_R0.584061.323
290_A294_G0.582281.319
114_L117_H0.581261.317
153_R156_P0.577411.308
297_L300_R0.577311.308
93_A98_R0.574151.301
98_R148_H0.573321.299
267_W270_A0.571911.296
314_Y318_V0.570821.293
126_L130_L0.569881.291
110_S202_I0.56981.291
192_F195_V0.567021.285
151_N154_G0.563651.277
241_L247_L0.556161.260
100_K218_E0.547571.241
247_L251_L0.546081.237
294_G297_L0.54371.232
146_M150_H0.542761.230
115_T127_G0.534641.211
101_A104_L0.53451.211
110_S206_A0.533161.208
158_E162_D0.532041.205
182_V185_V0.529541.200
59_A62_E0.528981.198
122_P125_L0.522221.183
206_A210_V0.522171.183
176_A288_M0.520791.180
119_S195_V0.520231.179
318_V322_S0.51871.175
123_V126_L0.516711.171
97_G218_E0.514541.166
103_L107_I0.513481.163
96_Y100_K0.507881.151
202_I206_A0.507481.150
300_R305_S0.505711.146
239_A242_S0.504341.143
196_A199_D0.501891.137
238_R241_L0.501731.137
175_V179_A0.500651.134
72_A76_V0.497331.127
49_A205_L0.496821.126
109_Y134_A0.49631.124
306_L311_L0.493791.119
156_P159_W0.493641.118
116_K195_V0.49321.117
212_I216_W0.490161.111
275_D279_P0.487881.105
128_R132_G0.486831.103
267_W272_D0.486741.103
99_K218_E0.486651.103
96_Y101_A0.486391.102
147_V151_N0.485461.100
317_A321_V0.484861.099
115_T124_L0.484051.097
203_V207_V0.48291.094
230_S233_F0.482281.093
155_F158_E0.481381.091
234_R238_R0.481151.090
88_F91_S0.475421.077
293_L296_S0.472291.070
268_T272_D0.470151.065
321_V325_I0.466341.057
268_T271_L0.464181.052
147_V150_H0.461891.046
306_L310_S0.461761.046
97_G101_A0.461041.045
293_L297_L0.460271.043
185_V189_W0.460071.042
106_C209_A0.456051.033
300_R304_K0.455621.032
181_V285_S0.4491.017
74_L125_L0.448981.017
276_E280_L0.4431.004
78_G132_G0.442881.003
196_A200_A0.441251.000
282_L286_S0.441150.999
151_N155_F0.440280.998
301_L306_L0.43670.989
61_Y71_I0.435550.987
195_V199_D0.435160.986
301_L311_L0.429320.973
94_D98_R0.426730.967
151_N156_P0.42550.964
244_P248_L0.423110.959
286_S290_A0.422780.958
146_M149_E0.422220.957
44_L171_G0.421790.956
46_A102_C0.420620.953
155_F159_W0.420130.952
78_G135_T0.420030.952
73_I77_A0.415560.942
311_L314_Y0.415540.941
148_H151_N0.41540.941
223_T227_S0.415150.941
313_R317_A0.414940.940
104_L107_I0.414870.940
209_A213_L0.414030.938
81_S132_G0.412870.935
183_A187_A0.409490.928
278_L282_L0.408530.926
159_W163_T0.408190.925
126_L129_V0.406710.921
251_L255_L0.403060.913
244_P247_L0.401330.909
178_G181_V0.399660.905
191_G196_A0.397460.900
294_G298_F0.395240.895
304_K307_R0.395180.895
107_I111_L0.395150.895
235_E238_R0.394620.894
297_L301_L0.393050.891
317_A320_A0.390040.884
322_S325_I0.388980.881
307_R311_L0.388540.880
127_G130_L0.388020.879
172_N176_A0.387720.878
73_I76_V0.386630.876
60_L64_Y0.386280.875
69_H73_I0.386220.875
74_L121_Y0.385030.872
49_A53_Q0.384130.870
171_G175_V0.384080.870
102_C142_F0.382750.867
140_S143_E0.382060.866
210_V213_L0.380910.863
73_I80_A0.379510.860
117_H123_V0.379160.859
299_S304_K0.378810.858
296_S300_R0.377980.856
103_L212_I0.377870.856
276_E281_G0.377830.856
159_W162_D0.377470.855
61_Y66_F0.376480.853
279_P283_I0.376320.853
136_S140_S0.375320.850
154_G157_Q0.374040.847
61_Y68_E0.373920.847
109_Y135_T0.373620.846
228_S232_S0.373460.846
157_Q304_K0.373420.846
113_C131_G0.373010.845
181_V185_V0.372190.843
313_R320_A0.371110.841
289_V292_M0.370790.840
180_G183_A0.369710.838
98_R218_E0.36940.837
109_Y113_C0.366940.831
62_E65_G0.366750.831
250_G254_S0.366560.830
277_E280_L0.365970.829
45_L208_A0.365290.828
111_L114_L0.365180.827
107_I110_S0.364740.826
78_G82_S0.362740.822
80_A84_I0.36060.817
314_Y317_A0.360420.817
77_A81_S0.359810.815
74_L77_A0.358220.812
229_L232_S0.35780.811
154_G158_E0.357230.809
246_I250_G0.35630.807
70_Q125_L0.356190.807
291_M295_S0.356010.807
105_F141_A0.355360.805
108_L130_L0.354320.803
128_R131_G0.354220.803
162_D165_S0.354160.802
106_C208_A0.353580.801
173_G291_M0.352730.799
199_D202_I0.351590.797
116_K202_I0.351270.796
75_F265_F0.35020.793
113_C201_A0.350080.793
87_T91_S0.349850.793
52_L201_A0.349390.792
73_I125_L0.349360.792
298_F301_L0.349190.791
53_Q201_A0.348760.790
211_L214_K0.347950.788
119_S122_P0.347240.787
47_M51_W0.345750.783
152_K156_P0.344650.781
273_P276_E0.344390.780
224_S227_S0.342750.777
283_I286_S0.342580.776
196_A203_V0.342160.775
84_I88_F0.341640.774
59_A63_S0.339110.768
241_L244_P0.338640.767
235_E239_A0.336430.762
110_S114_L0.335970.761
316_F320_A0.335010.759
78_G128_R0.334880.759
80_A83_A0.33240.753
247_L250_G0.331560.751
90_G93_A0.331520.751
113_C202_I0.331020.750
214_K217_P0.330960.750
109_Y138_L0.330820.750
177_I181_V0.328930.745
84_I87_T0.328710.745
233_F236_A0.328540.744
245_R248_L0.32570.738
103_L106_C0.324570.735
313_R316_F0.324470.735
258_G262_L0.324210.735
182_V186_L0.323480.733
141_A144_S0.323360.733
306_L314_Y0.323190.732
290_A293_L0.322560.731
207_V210_V0.322390.730
257_E260_M0.322330.730
243_D247_L0.322270.730
188_D278_L0.32010.725
204_L207_V0.319140.723
173_G176_A0.318370.721
187_A197_P0.318080.721
286_S289_V0.317450.719
106_C212_I0.316650.717
186_L196_A0.315120.714
263_F267_W0.315090.714
89_V101_A0.315050.714
161_S299_S0.314820.713
225_S228_S0.314350.712
186_L190_F0.31420.712
89_V140_S0.312210.707
102_C212_I0.311410.706
51_W172_N0.309520.701
308_P311_L0.309040.700
228_S236_A0.308850.700
270_A273_P0.308680.699
161_S165_S0.30850.699
259_S262_L0.308450.699
117_H199_D0.308330.699
234_R237_W0.307440.697
184_N188_D0.307430.697
79_F82_S0.307250.696
301_L305_S0.306970.695
180_G184_N0.30660.695
226_S230_S0.306260.694
277_E281_G0.3060.693
81_S86_G0.303170.687
76_V80_A0.303160.687
183_A186_L0.303160.687
75_F79_F0.302380.685
285_S288_M0.302210.685
306_L309_E0.301910.684
267_W271_L0.301690.684
281_G285_S0.301640.683
114_L199_D0.300330.680
117_H127_G0.299780.679
321_V324_A0.298960.677
253_Q257_E0.298790.677
109_Y131_G0.2970.673
189_W195_V0.296710.672
106_C205_L0.296460.672
158_E161_S0.294510.667
70_Q73_I0.294080.666
219_N222_D0.293670.665
85_F89_V0.293420.665
58_Y61_Y0.292840.663
72_A75_F0.292460.663
161_S304_K0.292360.662
173_G177_I0.292350.662
46_A138_L0.292230.662
227_S230_S0.292090.662
207_V211_L0.289450.656
94_D97_G0.289290.655
76_V79_F0.288020.653
132_G136_S0.287140.651
252_I256_F0.286730.650
60_L192_F0.28630.649
81_S84_I0.286270.649
151_N159_W0.285880.648
93_A144_S0.285460.647
81_S133_I0.28540.647
285_S289_V0.284860.645
208_A211_L0.28430.644
89_V93_A0.283950.643
254_S258_G0.283950.643
93_A101_A0.283580.642
260_M264_V0.282580.640
102_C141_A0.282330.640
61_Y64_Y0.281740.638
266_L269_P0.280810.636
98_R144_S0.280040.634
184_N281_G0.280010.634
177_I180_G0.279670.634
237_W241_L0.279520.633
51_W82_S0.279290.633
251_L254_S0.279120.632
225_S229_L0.279060.632
228_S231_G0.278710.631
223_T226_S0.27870.631
107_I206_A0.278210.630
187_A191_G0.278080.630
203_V206_A0.277530.629
236_A239_A0.277350.628
226_S229_L0.277340.628
257_E261_Y0.276440.626
200_A203_V0.275820.625
139_F142_F0.275790.625
322_S326_P0.275390.624
53_Q128_R0.274790.623
119_S127_G0.274440.622
299_S302_L0.273520.620
315_V318_V0.273480.620
183_A197_P0.273460.620
296_S299_S0.273210.619
48_A178_G0.272250.617
275_D283_I0.271930.616
117_H195_V0.271870.616
115_T131_G0.271770.616
291_M315_V0.271340.615
256_F260_M0.270790.614
312_L315_V0.270630.613
58_Y62_E0.270140.612
319_A322_S0.269730.611
150_H155_F0.268850.609
101_A105_F0.267340.606
157_Q162_D0.265760.602
177_I285_S0.265470.601
89_V92_L0.2650.600
278_L281_G0.264270.599
115_T128_R0.263970.598
68_E72_A0.263950.598
153_R158_E0.263810.598
208_A212_I0.263590.597
197_P201_A0.263550.597
315_V319_A0.262280.594
140_S144_S0.262260.594
179_A183_A0.262230.594
70_Q122_P0.261970.594
262_L266_L0.261010.591
153_R157_Q0.259290.587
82_S135_T0.258670.586
173_G180_G0.258440.586
213_L217_P0.258030.585
99_K213_L0.25790.584
160_L164_F0.257840.584
160_L165_S0.25770.584
77_A80_A0.256790.582
105_F138_L0.256760.582
63_S195_V0.256450.581
79_F83_A0.256270.581
177_I289_V0.255790.580
151_N157_Q0.255720.579
92_L137_L0.255350.579
252_I255_L0.255280.578
180_G285_S0.254680.577
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3o7qA0.91531000.371
1pw4A0.92091000.398
4j05A0.93791000.399
2gfpA0.85031000.433
4iu9B0.912499.90.462
4jr9A0.920999.90.462
4apsA0.920999.90.463
4gc0A0.898399.90.486
2cfqA0.892799.90.501
2xutA0.920999.90.537

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