GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF814 - Domain of unknown function (DUF814)
Pfam: PF05670 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 90
Sequences: 1279
Seq/Len: 14.21
HH_delta: 0.898 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
5_S60_E0.714993.152
33_W43_H0.572032.522
13_G19_N0.566112.496
4_S57_T0.558122.461
83_T87_Y0.551652.432
34_F46_L0.503072.218
31_D47_R0.469792.071
66_A78_V0.464462.048
6_D54_P0.451691.991
46_L57_T0.431311.901
44_V65_A0.414691.828
8_F57_T0.395271.743
45_I85_G0.381941.684
41_G65_A0.378531.669
36_A39_F0.345131.522
11_I26_Y0.343081.512
6_D57_T0.337431.488
27_A85_G0.330271.456
32_L84_Q0.329281.452
39_F72_W0.317131.398
62_A80_V0.308521.360
21_M26_Y0.304261.341
34_F58_L0.297471.311
4_S10_I0.292551.290
27_A45_I0.291241.284
28_R47_R0.290481.281
66_A80_V0.286021.261
14_R17_K0.28081.238
6_D56_P0.26891.185
59_Q63_Q0.268431.183
46_L53_E0.26241.157
24_K85_G0.256921.133
5_S57_T0.253011.115
32_L82_Y0.242691.070
55_P59_Q0.241681.065
67_S73_K0.240271.059
32_L58_L0.239911.058
8_F54_P0.238661.052
4_S8_F0.235461.038
39_F70_K0.234011.032
15_N18_E0.233481.029
12_V64_L0.233191.028
9_K47_R0.232431.025
19_N35_H0.230481.016
57_T60_E0.228831.009
56_P59_Q0.225470.994
12_V68_Y0.224450.990
26_Y47_R0.216620.955
16_A20_E0.21150.932
11_I47_R0.211110.931
21_M25_K0.207230.914
3_I9_K0.203360.897
54_P57_T0.203320.896
58_L62_A0.203250.896
34_F61_A0.197440.870
42_P65_A0.195240.861
4_S60_E0.195090.860
15_N37_D0.193680.854
10_I61_A0.192150.847
10_I46_L0.192040.847
8_F48_N0.191780.845
37_D41_G0.191290.843
48_N53_E0.190910.842
35_H43_H0.190610.840
11_I22_L0.185790.819
10_I60_E0.184530.814
57_T61_A0.183680.810
84_Q87_Y0.181780.801
85_G88_V0.178820.788
66_A73_K0.178480.787
30_N86_K0.177630.783
35_H40_P0.172880.762
3_I87_Y0.171640.757
30_N84_Q0.170750.753
12_V44_V0.170550.752
17_K88_V0.168450.743
19_N43_H0.168440.743
24_K84_Q0.168270.742
29_P85_G0.168260.742
44_V61_A0.168090.741
61_A65_A0.167080.737
50_P76_E0.166660.735
12_V65_A0.166020.732
30_N85_G0.164720.726
13_G35_H0.160440.707
46_L74_K0.159290.702
19_N80_V0.159180.702
32_L46_L0.158960.701
56_P70_K0.158460.699
52_D56_P0.157940.696
73_K78_V0.157410.694
34_F82_Y0.157090.693
83_T88_V0.156750.691
27_A33_W0.156220.689
34_F62_A0.156110.688
31_D49_N0.154830.683
63_Q77_K0.154490.681
19_N42_P0.153980.679
65_A69_S0.153920.679
20_E25_K0.153870.678
22_L46_L0.153450.676
64_L70_K0.151970.670
20_E90_K0.149290.658
6_D63_Q0.14830.654
17_K21_M0.147830.652
4_S64_L0.147560.651
36_A80_V0.146320.645
16_A90_K0.145670.642
44_V64_L0.145460.641
22_L26_Y0.145370.641
55_P84_Q0.14510.640
6_D60_E0.1440.635
27_A31_D0.143440.632
19_N22_L0.142050.626
50_P54_P0.140350.619
24_K27_A0.139730.616
51_G54_P0.139280.614
8_F47_R0.138880.612
30_N49_N0.138160.609
19_N33_W0.138020.608
14_R18_E0.137920.608
11_I88_V0.137610.607
4_S7_G0.136830.603
7_G64_L0.134710.594
37_D81_D0.134460.593
53_E56_P0.13420.592
42_P68_Y0.133960.591
14_R54_P0.132930.586
39_F90_K0.132280.583
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2iutA0.820.10.898
2hmaA0.888919.30.899
1jiwI0.514.80.904
1smpI0.488914.40.904
2iusA0.812.50.907
2j01J0.833311.10.909
3cf4A0.95568.70.913
1zavA0.87788.60.913
3u5wA0.95566.90.916
3j21A0.44446.90.916
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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