GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
CFEM - CFEM domain
Pfam: PF05730 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 66
Sequences: 784
Seq/Len: 11.88
HH_delta: 0.857 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
50_S53_D0.506032.811
23_C30_C0.413952.299
12_C44_C0.361982.011
9_A57_A0.337491.875
55_L59_N0.30111.672
37_F41_V0.297341.652
53_D56_T0.28851.602
45_V57_A0.269151.495
19_S40_A0.259031.439
59_N63_S0.245041.361
36_D39_S0.237381.319
35_Q39_S0.236941.316
16_A41_V0.231361.285
51_P55_L0.231251.284
56_T59_N0.224981.250
60_A64_L0.222451.236
31_L37_F0.214021.189
9_A61_A0.213411.185
14_N18_S0.209161.162
27_D30_C0.208021.155
17_I37_F0.206591.148
5_L9_A0.205411.141
8_C49_C0.195991.089
15_S48_S0.191151.062
29_A33_K0.188891.049
13_F37_F0.187421.041
7_S10_Q0.186661.037
33_K63_S0.185961.033
34_N37_F0.185471.030
6_P9_A0.18541.030
11_N14_N0.184721.026
52_D62_Q0.177980.989
41_V61_A0.17690.983
14_N36_D0.175720.976
29_A39_S0.17550.975
22_G31_L0.174920.972
58_L62_Q0.174550.970
34_N55_L0.174180.967
16_A43_D0.17320.962
16_A40_A0.171130.951
36_D40_A0.168880.938
17_I25_P0.167450.930
14_N25_P0.16420.912
3_Q10_Q0.16230.902
45_V54_Q0.162190.901
13_F46_Q0.161230.896
22_G34_N0.16070.893
11_N15_S0.160640.892
43_D47_S0.160560.892
29_A35_Q0.159360.885
15_S19_S0.157130.873
42_T46_Q0.154640.859
24_S29_A0.15330.852
55_L61_A0.151130.839
31_L45_V0.150460.836
52_D55_L0.149660.831
20_S37_F0.149640.831
13_F45_V0.149490.830
26_T63_S0.149340.830
34_N38_Q0.148550.825
29_A51_P0.14680.815
50_S57_A0.146250.812
30_C57_A0.145470.808
31_L43_D0.143790.799
35_Q38_Q0.143590.798
3_Q25_P0.143490.797
7_S11_N0.143250.796
38_Q42_T0.140380.780
39_S43_D0.140210.779
37_F46_Q0.139160.773
11_N50_S0.139090.773
24_S31_L0.138770.771
51_P54_Q0.135640.753
28_I33_K0.134610.748
11_N16_A0.134010.744
37_F40_A0.133880.744
17_I26_T0.133560.742
31_L41_V0.133320.741
9_A45_V0.133170.740
13_F16_A0.130860.727
3_Q64_L0.129960.722
50_S55_L0.129910.722
13_F48_S0.129320.718
37_F45_V0.129230.718
14_N43_D0.127630.709
38_Q55_L0.125580.698
46_Q51_P0.125420.697
32_C65_C0.125150.695
15_S57_A0.124880.694
9_A48_S0.123930.688
7_S18_S0.123160.684
20_S31_L0.121190.673
17_I46_Q0.121180.673
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
1aukA0.40913.80.857
2lamA0.43942.70.866
1wn8A0.15152.20.872
1wcoN0.515220.875
2gj0A0.45451.70.879
1kalA0.36361.70.879
1jjzA0.43941.60.881
2ln4A0.48481.30.887
2fqaA0.40911.20.888
4e6kG0.575810.893
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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