GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
UNC-93 - Ion channel regulatory protein UNC-93
Pfam: PF05978 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0015
Length: 156
Sequences: 56570
Seq/Len: 362.63
HH_delta: 0.083 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
87_P91_T3.209293.581
66_P116_S2.769773.090
118_S126_N2.724673.040
76_G102_G2.652782.960
49_S97_A2.448112.732
57_A105_L2.264372.527
67_K71_I2.124352.370
89_S93_Y1.990112.221
119_T122_T1.960582.188
88_N91_T1.958692.185
90_Y94_P1.888262.107
122_T125_R1.879432.097
83_S95_A1.671161.865
53_S101_F1.610251.797
65_G68_W1.606941.793
73_G105_L1.585911.770
61_V109_A1.548671.728
90_Y93_Y1.535911.714
68_W72_L1.479241.651
53_S56_F1.474491.645
56_F59_S1.434381.600
86_Y91_T1.432291.598
25_S28_E1.391821.553
59_S63_K1.383211.543
60_I64_L1.355931.513
86_Y95_A1.337841.493
64_L68_W1.271711.419
45_I97_A1.264811.411
49_S53_S1.250261.395
68_W71_I1.239721.383
91_T95_A1.234221.377
58_P62_N1.199351.338
36_A40_Y1.198981.338
80_Y95_A1.173431.309
45_I93_Y1.173271.309
115_T123_I1.169551.305
38_L41_Y1.152281.286
115_T127_T1.126711.257
120_E123_I1.110771.239
64_L69_S1.101041.229
24_H27_H1.098981.226
80_Y99_L1.07711.202
62_N66_P1.051841.174
37_G89_S1.050311.172
61_V66_P1.047041.168
46_L100_G1.034941.155
69_S72_L1.008111.125
114_L130_F1.004341.121
72_L76_G1.002911.119
55_L59_S0.994871.110
80_Y102_G0.9931.108
66_P112_T0.98591.100
60_I69_S0.984061.098
65_G69_S0.980671.094
91_T94_P0.967441.079
46_L103_A0.96271.074
22_V26_V0.961011.072
82_A85_F0.940631.050
20_E24_H0.926071.033
25_S29_R0.924641.032
124_G128_G0.917121.023
80_Y98_L0.914461.020
73_G102_G0.884960.987
134_F138_L0.881210.983
53_S104_A0.878670.980
70_M110_Q0.876210.978
143_L147_F0.865350.966
52_I56_F0.864080.964
24_H28_E0.862430.962
37_G40_Y0.85740.957
125_R129_I0.850270.949
48_G51_A0.849850.948
21_S24_H0.848870.947
70_M113_Y0.84830.947
144_F147_F0.830420.927
71_I75_L0.825010.921
108_T111_G0.821060.916
94_P98_L0.818980.914
112_T116_S0.816210.911
72_L75_L0.807140.901
27_H30_N0.80260.896
52_I55_L0.802490.895
37_G41_Y0.800440.893
132_A135_Q0.798580.891
77_Y103_A0.78980.881
36_A39_G0.787160.878
75_L79_I0.782760.873
94_P97_A0.780550.871
76_G80_Y0.776070.866
50_F103_A0.774670.864
21_S25_S0.76050.849
62_N112_T0.760160.848
71_I74_S0.759880.848
87_P90_Y0.758640.846
46_L50_F0.746660.833
50_F104_A0.723760.808
113_Y117_Y0.720230.804
140_F143_L0.711550.794
75_L78_A0.709470.792
111_G127_T0.704660.786
111_G130_F0.702920.784
105_L109_A0.693970.774
49_S100_G0.690530.770
44_A47_Y0.687140.767
96_S99_L0.683040.762
118_S122_T0.676590.755
106_L110_Q0.672890.751
45_I49_S0.671510.749
122_T126_N0.666050.743
74_S78_A0.655860.732
77_Y102_G0.655060.731
114_L127_T0.653770.729
22_V27_H0.653380.729
135_Q139_I0.653360.729
123_I127_T0.649910.725
107_W111_G0.648780.724
131_W134_F0.648580.724
18_I21_S0.648520.724
26_V29_R0.640980.715
23_I30_N0.63970.714
46_L96_S0.638620.713
44_A48_G0.63290.706
22_V25_S0.631020.704
40_Y45_I0.630870.704
73_G106_L0.629990.703
135_Q142_N0.628880.702
131_W135_Q0.62870.701
18_I145_L0.626980.700
108_T112_T0.626570.699
17_F20_E0.623220.695
110_Q130_F0.620210.692
50_F54_C0.609180.680
78_A82_A0.60230.672
104_A108_T0.600530.670
127_T131_W0.594440.663
47_Y50_F0.594420.663
66_P117_Y0.592220.661
57_A73_G0.584470.652
96_S100_G0.584230.652
85_F91_T0.58410.652
53_S57_A0.582230.650
137_S141_G0.577640.645
135_Q138_L0.576180.643
22_V30_N0.573750.640
77_Y99_L0.571640.638
87_P95_A0.570310.636
121_E125_R0.569360.635
95_A99_L0.5690.635
76_G98_L0.560760.626
58_P61_V0.558360.623
115_T118_S0.556240.621
49_S52_I0.554360.619
21_S30_N0.552430.616
132_A136_S0.549640.613
130_F133_I0.546060.609
100_G104_A0.543250.606
111_G131_W0.540850.603
129_I133_I0.53830.601
23_I27_H0.536240.598
56_F60_I0.536170.598
129_I132_A0.535770.598
86_Y90_Y0.535060.597
111_G115_T0.534030.596
81_I96_S0.532470.594
61_V108_T0.531590.593
69_S73_G0.525530.586
80_Y84_F0.523910.585
26_V30_N0.523260.584
29_R37_G0.522310.583
60_I63_K0.521680.582
128_G132_A0.521450.582
57_A61_V0.517810.578
80_Y83_S0.515660.575
110_Q113_Y0.513620.573
73_G109_A0.513030.572
79_I82_A0.513030.572
44_A96_S0.512010.571
85_F95_A0.511620.571
54_C107_W0.509990.569
24_H30_N0.509320.568
54_C108_T0.507230.566
114_L117_Y0.506380.565
23_I28_E0.50430.563
139_I142_N0.504030.562
97_A100_G0.496480.554
143_L146_F0.495840.553
140_F144_F0.494780.552
125_R128_G0.494660.552
48_G52_I0.491950.549
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4j05A0.987299.50.083
3o7qA0.961599.50.099
1pw4A0.955199.50.122
2gfpA0.961599.40.137
4gc0A0.993699.40.143
4jr9A0.955199.40.165
4iu9B0.955199.40.166
4apsA0.987299.40.169
2xutA0.961599.30.201
1pw4A0.961599.10.272

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