GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF914 - Eukaryotic protein of unknown function (DUF914)
Pfam: PF06027 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0184
Length: 334
Sequences: 10569
Seq/Len: 31.64
HH_delta: 0.756 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
99_A173_A0.979693.441
277_D283_Y0.877763.083
252_I256_M0.776712.728
95_L172_L0.772592.714
98_L172_L0.762142.677
138_G299_G0.7342.578
95_L175_L0.702272.467
50_N54_L0.689462.422
129_R188_E0.666292.341
123_S129_R0.66212.326
118_F177_A0.64422.263
171_L175_L0.64322.259
109_Q273_A0.642842.258
120_M139_V0.611592.148
114_T118_F0.558191.961
107_S170_D0.554511.948
290_I294_A0.517131.817
122_L185_V0.516411.814
75_L78_P0.512161.799
103_T170_D0.511931.798
133_W137_L0.503981.770
26_T272_Y0.500581.758
46_Q50_N0.496741.745
252_I255_R0.478571.681
118_F181_A0.461961.623
287_W291_L0.460161.616
145_G292_A0.457051.606
243_L246_F0.456221.603
132_S135_H0.455961.602
78_P193_K0.445861.566
98_L102_Y0.44241.554
103_T169_G0.441971.553
91_E179_L0.441941.552
105_V277_D0.441871.552
102_Y169_G0.437351.536
108_V173_A0.433581.523
145_G296_I0.432251.518
268_T272_Y0.429011.507
276_I280_F0.426681.499
102_Y168_L0.425991.496
294_A298_I0.424631.492
140_L144_A0.418951.472
138_G303_Y0.416611.463
95_L179_L0.415881.461
32_S97_V0.407971.433
122_L182_V0.406311.427
103_T107_S0.406121.427
33_S37_N0.40321.416
167_I171_L0.403121.416
119_V263_N0.400461.407
76_K80_W0.399941.405
148_L288_L0.398371.399
110_L150_V0.397561.397
169_G173_A0.397051.395
142_C267_L0.39591.391
136_I140_L0.394121.384
26_T276_I0.393051.381
148_L295_L0.392641.379
98_L101_Q0.391941.377
138_G302_V0.39121.374
96_V100_Y0.387261.360
118_F178_I0.386321.357
77_R80_W0.385961.356
123_S127_L0.384891.352
47_S51_Y0.384881.352
195_P198_E0.382491.344
110_L293_F0.380041.335
254_L258_S0.37791.327
84_L186_L0.376221.322
142_C299_G0.375121.318
30_T33_S0.371771.306
26_T30_T0.367641.291
286_S289_Y0.367611.291
111_L173_A0.364821.282
122_L178_I0.363771.278
168_L172_L0.362921.275
106_T274_L0.362871.275
258_S261_F0.36251.273
86_A206_F0.36031.266
120_M131_Y0.359421.263
187_E251_P0.35871.260
149_V292_A0.358151.258
127_L185_V0.356021.251
100_Y108_V0.355481.249
124_F131_Y0.354831.246
81_K186_L0.353961.243
33_S283_Y0.35371.242
88_L182_V0.351791.236
181_A185_V0.350951.233
209_I213_I0.348831.225
272_Y276_I0.348451.224
230_S234_G0.347251.220
122_L181_A0.346461.217
301_V305_L0.346011.215
111_L177_A0.344411.210
55_A208_F0.339071.191
177_A181_A0.336361.182
125_I128_K0.336231.181
51_Y54_L0.335471.178
89_D183_S0.332521.168
119_V259_A0.329481.157
83_F206_F0.328121.153
131_Y136_I0.32721.149
189_K192_K0.324941.141
144_A148_L0.32411.139
26_T29_G0.318361.118
104_S107_S0.318251.118
124_F130_R0.317811.116
105_V281_F0.316981.113
119_V181_A0.315871.110
173_A177_A0.315661.109
75_L79_W0.315231.107
102_Y172_L0.314511.105
30_T276_I0.314391.104
26_T33_S0.314051.103
189_K193_K0.310641.091
117_P139_V0.309321.087
111_L174_L0.308671.084
274_L285_F0.30861.084
129_R135_H0.307881.082
213_I216_A0.307371.080
26_T34_L0.306261.076
300_F304_N0.305511.073
61_I65_R0.304291.069
208_F212_G0.304081.068
188_E192_K0.302481.063
114_T146_V0.301891.060
151_V286_S0.300021.054
285_F290_I0.298581.049
182_V186_L0.296251.041
253_V257_S0.292681.028
122_L125_I0.292281.027
77_R81_K0.291641.024
80_W84_L0.289971.019
129_R260_T0.285731.004
291_L295_L0.283660.996
119_V185_V0.283230.995
253_V262_F0.283010.994
145_G299_G0.282260.992
92_A179_L0.282080.991
210_I213_I0.281470.989
287_W290_I0.278360.978
117_P142_C0.276790.972
285_F289_Y0.276530.971
229_T232_V0.276440.971
52_V208_F0.275820.969
46_Q51_Y0.275380.967
229_T233_I0.274830.965
132_S136_I0.274540.964
76_K79_W0.274370.964
48_F51_Y0.272770.958
105_V109_Q0.272670.958
180_Y184_N0.27230.957
246_F250_V0.271720.955
59_T201_G0.270350.950
29_G32_S0.270270.949
188_E259_A0.269110.945
201_G205_L0.268770.944
277_D281_F0.268660.944
268_T271_F0.266510.936
118_F122_L0.266170.935
134_F302_V0.265750.934
99_A108_V0.265380.932
119_V123_S0.265140.931
60_P63_L0.262940.924
133_W136_I0.262810.923
148_L291_L0.261840.920
230_S233_I0.260840.916
264_L267_L0.259560.912
208_F211_S0.259210.911
46_Q54_L0.258640.909
78_P81_K0.257980.906
239_Y244_F0.257160.903
103_T108_V0.255510.898
240_A244_F0.254960.896
199_F203_L0.254490.894
178_I182_V0.253970.892
33_S36_A0.253350.890
143_I147_V0.253120.889
96_V108_V0.252820.888
44_T51_Y0.252430.887
56_L60_P0.252360.886
231_Q234_G0.252160.886
88_L186_L0.250290.879
265_S268_T0.249170.875
99_A103_T0.248380.873
213_I217_I0.247910.871
94_Y98_L0.246350.865
202_M205_L0.246020.864
242_C245_L0.245730.863
184_N254_L0.244970.861
122_L126_F0.244790.860
78_P194_A0.24470.860
105_V283_Y0.244120.858
87_L210_I0.243340.855
275_I279_F0.242360.851
146_V150_V0.24180.849
290_I293_F0.24040.844
126_F182_V0.239370.841
92_A183_S0.238810.839
257_S262_F0.237190.833
188_E258_S0.237040.833
32_S36_A0.236680.831
242_C246_F0.236310.830
110_L147_V0.235960.829
174_L177_A0.235640.828
234_G238_G0.235560.827
271_F293_F0.235230.826
206_F210_I0.235050.826
89_D247_Y0.234860.825
284_K287_W0.233890.822
110_L149_V0.232680.817
119_V184_N0.232340.816
82_Y199_F0.231640.814
205_L209_I0.231530.813
49_F52_V0.231290.812
286_S290_I0.231170.812
191_V199_F0.230870.811
31_F34_L0.230150.808
232_V235_L0.22940.806
120_M184_N0.228810.804
90_V93_N0.228550.803
167_I170_D0.228440.802
51_Y55_A0.228350.802
250_V253_V0.228180.802
52_V56_L0.227750.800
137_L144_A0.227610.800
184_N250_V0.227590.799
275_I278_I0.22720.798
129_R259_A0.227130.798
28_T33_S0.22710.798
180_Y250_V0.226010.794
111_L170_D0.225720.793
43_P46_Q0.225490.792
130_R134_F0.22540.792
88_L179_L0.225020.790
274_L278_I0.224720.789
45_F49_F0.224590.789
168_L171_L0.223940.787
170_D174_L0.223510.785
86_A90_V0.223270.784
59_T63_L0.223190.784
30_T273_A0.223040.784
79_W83_F0.222150.780
114_T142_C0.221930.780
276_I279_F0.219840.772
249_L253_V0.219720.772
141_I299_G0.21960.771
254_L262_F0.219530.771
187_E199_F0.218820.769
278_I285_F0.218350.767
263_N266_L0.217380.764
172_L175_L0.216940.762
134_F305_L0.216570.761
81_K85_L0.216390.760
237_V240_A0.216070.759
141_I298_I0.214890.755
64_Y67_G0.214730.754
26_T31_F0.214590.754
27_G30_T0.214080.752
30_T34_L0.214020.752
103_T173_A0.213410.750
207_G211_S0.21340.750
249_L252_I0.213060.748
216_A220_R0.212450.746
138_G142_C0.212440.746
166_P170_D0.212070.745
89_D203_L0.212060.745
117_P143_I0.21020.738
95_L176_G0.210120.738
102_Y166_P0.210110.738
137_L141_I0.209960.738
214_Q218_L0.209830.737
135_H258_S0.209380.736
63_L67_G0.2090.734
60_P64_Y0.208880.734
236_L240_A0.207860.730
198_E202_M0.207270.728
289_Y293_F0.206880.727
120_M124_F0.206230.724
74_V77_R0.206140.724
31_F35_L0.205690.723
50_N53_L0.205660.722
144_A295_L0.205080.720
55_A205_L0.204940.720
183_S187_E0.204730.719
82_Y194_A0.204670.719
91_E95_L0.204550.719
86_A210_I0.203610.715
113_C177_A0.203510.715
236_L239_Y0.203240.714
248_S252_I0.203240.714
248_S251_P0.202440.711
141_I302_V0.202260.711
148_L289_Y0.200980.706
109_Q113_C0.200640.705
127_L188_E0.200610.705
194_A199_F0.200540.704
113_C116_I0.200510.704
61_I64_Y0.200140.703
31_F235_L0.198690.698
234_G237_V0.198310.697
293_F297_I0.198240.696
299_G302_V0.197230.693
89_D93_N0.196970.692
47_S50_N0.196870.692
123_S259_A0.196850.692
278_I282_G0.196810.691
28_T31_F0.196790.691
183_S203_L0.19660.691
180_Y247_Y0.196030.689
247_Y250_V0.195680.687
44_T94_Y0.195670.687
49_F212_G0.195490.687
29_G109_Q0.195290.686
83_F87_L0.195280.686
47_S97_V0.195120.685
74_V78_P0.195110.685
44_T50_N0.194780.684
96_V176_G0.194630.684
147_V151_V0.193570.680
54_L58_Y0.193380.679
297_I301_V0.193340.679
86_A89_D0.192640.677
89_D92_A0.19240.676
298_I302_V0.192320.676
149_V296_I0.192250.675
261_F303_Y0.192220.675
206_F209_I0.192140.675
220_R223_I0.191910.674
115_S266_L0.191460.673
120_M135_H0.19130.672
202_M206_F0.190970.671
99_A169_G0.190530.669
105_V270_D0.190380.669
80_W83_F0.189870.667
112_D180_Y0.189810.667
104_S108_V0.189590.666
95_L98_L0.189220.665
250_V254_L0.189170.665
165_N168_L0.188640.663
54_L57_V0.188340.662
120_M136_I0.188260.661
286_S291_L0.188230.661
142_C183_S0.187750.660
91_E175_L0.187390.658
100_Y104_S0.187340.658
65_R68_F0.186750.656
241_L245_L0.186450.655
79_W206_F0.186050.654
31_F238_G0.186010.653
115_S180_Y0.185990.653
81_K189_K0.185680.652
246_F251_P0.185090.650
121_I124_F0.1850.650
79_W82_Y0.184490.648
148_L292_A0.183950.646
300_F303_Y0.183720.645
228_W232_V0.183590.645
26_T273_A0.183260.644
123_S126_F0.183180.643
100_Y109_Q0.182870.642
51_Y207_G0.182720.642
83_F210_I0.182630.642
245_L249_L0.18250.641
34_L37_N0.182440.641
149_V270_D0.182160.640
43_P50_N0.182010.639
210_I214_Q0.181960.639
29_G33_S0.18080.635
143_I267_L0.180580.634
131_Y135_H0.180050.632
284_K289_Y0.179490.631
53_L57_V0.179480.630
257_S261_F0.17880.628
62_L201_G0.178710.628
278_I284_K0.178660.628
28_T100_Y0.177630.624
29_G96_V0.177070.622
44_T49_F0.176820.621
243_L247_Y0.176790.621
211_S214_Q0.176780.621
48_F52_V0.176250.619
142_C264_L0.176080.619
288_L291_L0.174340.612
115_S177_A0.174050.611
75_L80_W0.173920.611
62_L65_R0.173090.608
104_S170_D0.172370.606
266_L269_S0.172330.605
50_N56_L0.172020.604
245_L248_S0.171960.604
192_K195_P0.171910.604
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2i68A0.386298.90.756
3b5dA0.326398.30.804
3b5dA0.326398.20.81
2i68A0.4072980.822
4he8J0.52194.30.89
4j05A0.952190.40.903
3l1lA0.859379.30.916
3rkoJ0.538967.80.923
1pw4A0.901261.50.926
3b9wA0.763551.80.93
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

Page generated in 0.0466 seconds.