GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF915 - Alphabeta hydrolase of unknown function (DUF915)
Pfam: PF06028 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0028
Length: 255
Sequences: 38120
Seq/Len: 149.49
HH_delta: 0.134 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
106_N135_K3.970544.556
121_L136_L2.408692.764
226_K247_L2.393942.747
188_L251_F2.311142.652
193_D229_T2.241392.572
50_S88_W2.236382.566
38_Q249_I2.099232.409
107_L117_W1.881092.158
104_K134_N1.823522.092
213_R223_Y1.813282.080
193_D200_S1.799582.065
30_M245_D1.733381.989
90_K120_Y1.726181.981
140_A201_D1.716621.970
193_D227_T1.673621.920
228_V247_L1.645631.888
90_K94_K1.628581.869
106_N134_N1.617171.855
106_N252_L1.613371.851
138_T141_G1.578071.811
17_I89_L1.571181.803
90_K124_Y1.544751.772
206_N227_T1.513431.736
191_Y209_S1.501111.722
139_I244_V1.493461.714
13_P43_K1.432211.643
187_V216_L1.396441.602
114_G141_G1.37991.583
119_Y123_N1.379371.583
117_W136_L1.342591.540
19_G111_S1.331131.527
210_L227_T1.325511.521
106_N137_V1.321411.516
247_L250_Q1.318511.513
206_N210_L1.309311.502
118_T138_T1.279251.468
137_V248_I1.278331.467
13_P45_L1.277741.466
136_L187_V1.267571.454
33_R245_D1.266471.453
16_F108_V1.263941.450
213_R225_E1.249241.433
94_K132_K1.241291.424
119_Y122_E1.222551.403
21_G111_S1.219011.399
120_Y124_Y1.19311.369
87_K123_N1.174291.347
89_L120_Y1.167941.340
17_I117_W1.163621.335
108_V139_I1.156311.327
243_Q247_L1.154351.324
52_N88_W1.149191.319
14_T108_V1.148941.318
210_L225_E1.14751.317
191_Y227_T1.143331.312
93_L105_F1.139851.308
246_K250_Q1.134111.301
90_K123_N1.129491.296
188_L226_K1.117081.282
211_S215_L1.103851.266
16_F27_F1.100921.263
12_T104_K1.100641.263
33_R249_I1.095391.257
124_Y132_K1.09141.252
191_Y206_N1.082681.242
33_R38_Q1.062391.219
138_T189_N1.058651.215
137_V188_L1.057421.213
31_I46_T1.048341.203
86_A119_Y1.039641.193
210_L214_Y1.030581.182
17_I107_L1.023361.174
12_T106_N1.02171.172
111_S235_H1.018761.169
93_L133_L1.012281.161
81_N84_K1.011741.161
33_R37_K1.009381.158
224_Q247_L1.006311.155
22_G26_S0.997651.145
135_K251_F0.994481.141
24_A48_T0.993921.140
193_D206_N0.977021.121
108_V137_V0.974971.119
110_H140_A0.974241.118
13_P102_F0.956311.097
191_Y225_E0.94971.090
233_A241_N0.947711.087
20_Y112_M0.940531.079
135_K188_L0.936281.074
109_G117_W0.933591.071
51_K54_K0.929781.067
230_G233_A0.929361.066
135_K186_Q0.929181.066
244_V248_I0.918731.054
38_Q42_Q0.917191.052
211_S214_Y0.895591.028
90_K132_K0.893731.025
83_K123_N0.892021.023
210_L213_R0.877761.007
137_V252_L0.875521.005
228_V233_A0.874761.004
42_Q106_N0.874551.003
94_K124_Y0.873371.002
105_F133_L0.865470.993
233_A237_Q0.863550.991
190_I244_V0.860910.988
125_G132_K0.854460.980
243_Q246_K0.851280.977
216_L223_Y0.848530.974
14_T42_Q0.843370.968
92_V95_Y0.841910.966
126_N132_K0.838990.963
188_L224_Q0.83620.959
15_I105_F0.831050.953
92_V96_L0.829660.952
48_T53_G0.824740.946
218_N223_Y0.822560.944
200_S230_G0.810190.930
190_I228_V0.808610.928
140_A192_G0.806430.925
110_H236_S0.804690.923
213_R217_K0.799270.917
16_F44_V0.797590.915
96_L102_F0.795940.913
91_K94_K0.794970.912
217_K223_Y0.78820.904
247_L251_F0.780630.896
13_P105_F0.78010.895
189_N223_Y0.777220.892
228_V243_Q0.77640.891
17_I49_V0.776230.891
136_L185_I0.76760.881
193_D230_G0.76410.877
166_M169_M0.762260.875
168_P172_D0.76180.874
109_G113_G0.759580.871
49_V52_N0.759320.871
110_H139_I0.752980.864
86_A90_K0.750260.861
87_K90_K0.749570.860
190_I226_K0.744610.854
107_L133_L0.743560.853
15_I93_L0.742080.851
189_N209_S0.741850.851
110_H238_L0.741680.851
50_S54_K0.741070.850
87_K91_K0.739740.849
209_S225_E0.737620.846
85_Q112_M0.735050.843
25_N28_N0.733890.842
12_T134_N0.727880.835
167_T171_Q0.727450.835
47_V92_V0.720780.827
208_S211_S0.714770.820
191_Y204_V0.711860.817
115_L142_P0.708920.813
168_P171_Q0.707960.812
189_N213_R0.707340.812
118_T212_L0.699570.803
35_E44_V0.693170.795
21_G112_M0.686930.788
93_L120_Y0.68690.788
207_A210_L0.684760.786
88_W91_K0.678960.779
91_K95_Y0.67630.776
86_A116_S0.6760.776
105_F134_N0.675930.776
45_L92_V0.673610.773
190_I247_L0.671160.770
32_N37_K0.664060.762
112_M116_S0.658440.755
45_L96_L0.656190.753
135_K252_L0.653860.750
189_N212_L0.651490.747
31_I35_E0.651110.747
226_K243_Q0.647880.743
12_T42_Q0.64480.740
29_H32_N0.644510.739
120_Y133_L0.644220.739
84_K87_K0.642470.737
88_W92_V0.639730.734
14_T106_N0.637770.732
233_A240_E0.635930.730
169_M172_D0.634160.728
14_T44_V0.626050.718
144_N147_L0.625440.718
15_I92_V0.623080.715
14_T34_L0.622630.714
13_P96_L0.622570.714
109_G114_G0.618140.709
246_K249_I0.615690.706
17_I47_V0.613970.704
102_F105_F0.612950.703
201_D204_V0.612930.703
172_D175_K0.612380.703
139_I248_I0.610730.701
134_N137_V0.608570.698
47_V89_L0.607790.697
82_Y85_Q0.606670.696
42_Q252_L0.597410.685
209_S213_R0.594850.682
83_K87_K0.59460.682
48_T54_K0.594380.682
15_I107_L0.593130.681
48_T51_K0.591470.679
107_L120_Y0.590710.678
43_K102_F0.58920.676
144_N211_S0.585120.671
80_A84_K0.584510.671
120_Y132_K0.583730.670
35_E38_Q0.582220.668
31_I44_V0.580520.666
192_G237_Q0.578170.663
27_F110_H0.576830.662
192_G200_S0.57630.661
83_K119_Y0.576010.661
135_K138_T0.574350.659
224_Q251_F0.573390.658
43_K46_T0.572590.657
121_L185_I0.57140.656
117_W121_L0.570060.654
24_A54_K0.569680.654
140_A191_Y0.569240.653
224_Q250_Q0.568460.652
18_H23_T0.566760.650
137_V190_I0.564570.648
32_N35_E0.563930.647
245_D249_I0.558820.641
223_Y226_K0.556740.639
234_Q240_E0.556270.638
86_A123_N0.553140.635
24_A46_T0.549240.630
18_H52_N0.549120.630
26_S238_L0.545410.626
117_W138_T0.544680.625
105_F132_K0.544630.625
178_R181_F0.543950.624
108_V248_I0.543820.624
48_T52_N0.5430.623
42_Q249_I0.542050.622
118_T143_F0.540150.620
19_G22_G0.539480.619
139_I190_I0.538830.618
155_Q159_N0.538730.618
16_F31_I0.538610.618
28_N46_T0.536550.616
13_P42_Q0.531390.610
28_N32_N0.528120.606
37_K249_I0.527860.606
84_K88_W0.526890.605
88_W95_Y0.525490.603
17_I116_S0.523540.601
121_L133_L0.522250.599
209_S212_L0.521260.598
16_F34_L0.518740.595
29_H245_D0.515750.592
18_H47_V0.513910.590
83_K86_A0.513850.590
188_L247_L0.513220.589
115_L118_T0.510990.586
107_L136_L0.509010.584
225_E229_T0.506510.581
85_Q88_W0.505160.580
17_I51_K0.502020.576
15_I45_L0.498010.571
101_H104_K0.493980.567
20_Y111_S0.492490.565
212_L216_L0.491550.564
137_V251_F0.489440.562
183_K216_L0.487940.560
133_L136_L0.486930.559
122_E182_P0.486040.558
109_G121_L0.485580.557
49_V116_S0.485140.557
201_D235_H0.484840.556
139_I238_L0.484710.556
16_F46_T0.484380.556
111_S236_S0.483890.555
24_A47_V0.482730.554
19_G110_H0.48030.551
103_K132_K0.478580.549
189_N216_L0.478160.549
172_D176_N0.477160.547
112_M115_L0.476520.547
245_D248_I0.476060.546
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3fleA0.968699.90.134
1b6gA0.839299.90.164
2wtmA0.847199.90.173
3hjuA0.858899.90.174
3i28A0.843199.90.176
3fobA0.831499.90.18
3v48A0.831499.90.181
2pujA0.835399.90.182
3lp5A0.905999.90.184
3bf7A0.827599.90.185

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