GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
TRI12 - Fungal trichothecene efflux pump (TRI12)
Pfam: PF06609 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0015
Length: 599
Sequences: 5441
Seq/Len: 9.08
HH_delta: 0.627 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
129_Q133_T0.737474.926
250_G284_L0.604264.037
434_V442_A0.532183.555
274_I278_V0.519563.471
246_L290_W0.507793.392
132_N136_A0.492093.287
304_R438_D0.491483.283
123_I127_T0.470263.141
249_A283_L0.449553.003
365_G417_F0.44792.992
124_V137_G0.433612.897
130_N133_T0.431142.880
126_A200_Y0.428972.866
119_V206_S0.422322.821
391_T544_V0.416892.785
275_A279_I0.415682.777
117_L144_G0.404732.704
86_A139_V0.378982.532
254_F280_G0.369672.469
107_R157_E0.368592.462
285_V289_V0.359972.405
537_Y541_A0.356252.380
393_F415_A0.355072.372
242_I290_W0.351152.346
257_G277_L0.348762.330
112_I210_L0.342992.291
361_G413_V0.335242.239
344_D350_E0.33372.229
271_A275_A0.332762.223
395_G540_I0.326642.182
388_V547_I0.326312.180
398_A537_Y0.319412.134
388_V392_A0.309152.065
90_A139_V0.306662.049
385_F421_G0.303672.029
393_F418_G0.30272.022
314_A552_F0.302492.021
396_A411_F0.299051.998
468_K534_Y0.296591.981
191_A345_P0.291161.945
320_F453_G0.2861.911
343_S354_I0.278141.858
468_K472_E0.273931.830
163_W166_L0.272231.819
87_W145_A0.268181.791
253_L276_P0.266971.783
548_I552_F0.264981.770
269_K274_I0.26431.766
121_G140_L0.262971.757
238_E298_D0.262141.751
526_E530_H0.261761.749
128_A133_T0.25991.736
435_P438_D0.258491.727
185_I188_L0.255151.704
261_G268_W0.254241.698
160_P163_W0.252321.686
250_G280_G0.251111.677
133_T137_G0.249871.669
277_L281_F0.247041.650
246_L283_L0.245461.640
113_I117_L0.245261.638
284_L288_V0.244171.631
94_S143_V0.242271.618
336_Q341_F0.239991.603
464_I538_S0.239711.601
253_L279_I0.235121.571
240_D243_G0.235111.571
249_A253_L0.232711.555
122_S202_F0.232631.554
116_L210_L0.231231.545
131_M135_I0.22991.536
468_K471_K0.229721.535
128_A137_G0.228121.524
288_V292_W0.227541.520
280_G284_L0.226911.516
292_W304_R0.226161.511
372_L376_I0.225561.507
306_F313_A0.224071.497
256_L260_W0.222591.487
399_A411_F0.221961.483
302_P438_D0.220791.475
453_G457_G0.220311.472
260_W266_Y0.221.470
472_E530_H0.219621.467
350_E353_W0.219231.464
207_G211_V0.217491.453
103_D440_G0.217421.452
161_N164_R0.216951.449
313_A317_V0.216281.445
302_P441_T0.215171.437
350_E354_I0.212921.422
253_L283_L0.21141.412
327_F454_G0.211081.410
101_L110_F0.2111.409
246_L286_A0.210571.407
188_L192_H0.210011.403
402_P526_E0.208271.391
472_E475_K0.207821.388
90_A94_S0.207821.388
365_G420_G0.207761.388
386_G422_I0.207551.386
191_A346_I0.206381.379
189_F193_S0.205841.375
165_G370_G0.204671.367
76_G131_M0.204521.366
203_I207_G0.204141.364
116_L120_V0.204021.363
289_V293_F0.203451.359
391_T395_G0.203421.359
136_A140_L0.202631.354
124_V133_T0.202281.351
398_A540_I0.201941.349
393_F414_L0.199931.336
391_T547_I0.199891.335
381_W385_F0.199881.335
189_F197_W0.197451.319
112_I116_L0.196931.316
385_F389_L0.196891.315
386_G418_G0.196551.313
241_W245_F0.19621.311
328_S461_Y0.196181.310
121_G144_G0.195911.309
125_C137_G0.195751.308
281_F285_V0.194631.300
530_H534_Y0.194081.296
102_S150_L0.192041.283
121_G137_G0.191821.281
371_L375_K0.191271.278
193_S197_W0.191231.277
115_S209_A0.190511.273
521_V525_Q0.18961.267
325_N543_G0.188791.261
547_I551_L0.188311.258
98_V114_G0.18761.253
400_V404_N0.18751.253
392_A396_A0.186521.246
386_G421_G0.185651.240
361_G365_G0.184011.229
123_I203_I0.183371.225
279_I283_L0.183141.223
156_S439_I0.183091.223
257_G280_G0.182921.222
233_R237_K0.182491.219
76_G79_N0.182381.218
93_V248_I0.181831.215
112_I214_F0.181721.214
249_A279_I0.180791.208
159_V167_G0.180431.205
387_S546_A0.180061.203
278_V282_V0.179681.200
498_L501_G0.178941.195
522_A526_E0.178611.193
472_E476_Y0.177951.189
273_V276_P0.176431.179
317_V549_A0.175351.171
369_L421_G0.175261.171
95_F447_G0.175091.170
257_G273_V0.174911.168
250_G283_L0.17451.166
402_P529_A0.173491.159
522_A525_Q0.173011.156
66_I70_I0.172611.153
121_G124_V0.172481.152
338_V351_I0.172271.151
540_I544_V0.172231.151
266_Y273_V0.171621.146
103_D107_R0.171061.143
243_G291_E0.171.136
262_G267_P0.16961.133
288_V303_H0.168611.126
410_A414_L0.166941.115
290_W294_G0.166891.115
394_C539_S0.166431.112
124_V127_T0.165941.108
183_P352_G0.165481.105
85_T259_S0.164291.097
125_C134_F0.164261.097
282_V286_A0.163891.095
132_N135_I0.163571.093
266_Y272_H0.163331.091
124_V140_L0.162921.088
311_G554_G0.162331.084
120_V124_V0.161311.078
324_M542_F0.160691.073
136_A139_V0.15971.067
251_L452_I0.15961.066
316_L445_L0.159561.066
273_V277_L0.159251.064
324_M457_G0.159111.063
169_A173_I0.1591.062
465_F535_V0.158381.058
315_L430_A0.158051.056
66_I198_I0.157411.052
314_A549_A0.156591.046
251_L448_S0.156461.045
114_G147_V0.15621.043
336_Q529_A0.155911.041
187_Q352_G0.155321.038
94_S146_G0.154691.033
357_P361_G0.154531.032
97_F244_I0.154381.031
321_I549_A0.15411.029
66_I190_A0.153661.026
67_L84_S0.153221.024
384_I550_A0.152581.019
283_L286_A0.151681.013
244_I248_I0.151321.011
529_A533_R0.149370.998
165_G169_A0.148580.993
416_G420_G0.148560.992
138_M141_Y0.148520.992
98_V147_V0.148010.989
272_H275_A0.147870.988
245_F249_A0.14780.987
270_S275_A0.147330.984
376_I382_Q0.147240.984
266_Y270_S0.146980.982
472_E531_A0.146580.979
110_F113_I0.146490.979
373_F425_P0.146220.977
301_F445_L0.145490.972
393_F411_F0.145390.971
253_L280_G0.145340.971
409_I413_V0.14480.967
286_A289_V0.144320.964
380_K384_I0.144120.963
257_G276_P0.144070.962
270_S273_V0.14320.957
79_N132_N0.142410.951
390_M543_G0.14240.951
410_A413_V0.142260.950
372_L382_Q0.142240.950
287_F291_E0.142160.950
267_P270_S0.141240.943
430_A446_T0.141080.942
531_A535_V0.141050.942
311_G314_A0.140820.941
285_V288_V0.140720.940
286_A290_W0.140620.939
289_V292_W0.139610.933
390_M418_G0.13960.933
271_A279_I0.139570.932
247_F287_F0.139470.932
311_G429_I0.139350.931
183_P186_A0.139160.930
125_C128_A0.138880.928
243_G290_W0.13850.925
310_R554_G0.138250.924
190_A196_R0.138110.923
114_G146_G0.137840.921
534_Y538_S0.137830.921
211_V216_F0.137220.917
389_L417_F0.136550.912
282_V285_V0.136540.912
161_N432_L0.136280.910
381_W384_I0.135450.905
397_M400_V0.13540.904
172_S366_A0.135290.904
353_W356_S0.135150.903
258_L261_G0.135090.902
310_R315_L0.134560.899
250_G288_V0.134260.897
119_V207_G0.134160.896
175_F179_T0.134160.896
84_S331_I0.134120.896
494_L500_A0.133940.895
269_K273_V0.133840.894
103_D106_G0.133450.891
83_F131_M0.133230.890
387_S547_I0.132740.887
202_F416_G0.132740.887
156_S164_R0.132480.885
191_A344_D0.132270.884
186_A190_A0.132190.883
323_G454_G0.132150.883
311_G433_I0.131880.881
115_S206_S0.131750.880
127_T137_G0.131720.880
205_W208_I0.131720.880
102_S107_R0.13160.879
91_S145_A0.131490.878
271_A274_I0.131480.878
291_E300_L0.13140.878
548_I551_L0.131260.877
108_R112_I0.131070.876
138_M142_G0.131010.875
279_I286_A0.130980.875
308_D554_G0.130750.873
111_F154_A0.130360.871
172_S176_I0.130320.871
122_S203_I0.130220.870
379_I429_I0.130220.870
274_I281_F0.130120.869
238_E297_K0.13010.869
316_L449_I0.129640.866
307_K313_A0.129090.862
364_A413_V0.128910.861
173_I176_I0.128810.860
541_A545_V0.128750.860
133_T136_A0.128710.860
304_R307_K0.128210.856
291_E294_G0.128090.856
472_E534_Y0.128080.856
383_L553_L0.127850.854
365_G369_L0.127760.853
118_G138_M0.127650.853
92_A451_S0.127160.849
82_W86_A0.127120.849
123_I200_Y0.127090.849
145_A148_Q0.126860.847
337_V354_I0.126070.842
544_V548_I0.126010.842
331_I458_Y0.125660.839
343_S350_E0.125260.837
138_M204_I0.124740.833
389_L414_L0.124160.829
127_T200_Y0.123870.827
310_R313_A0.12360.826
318_I387_S0.123510.825
192_H346_I0.123370.824
129_Q137_G0.123310.824
469_L531_A0.12320.823
391_T543_G0.122990.822
326_F330_N0.122980.822
431_Q443_T0.122810.820
174_P178_T0.12230.817
338_V345_P0.122050.815
294_G299_P0.121730.813
449_I453_G0.121710.813
308_D311_G0.121630.812
109_Y113_I0.121220.810
319_S446_T0.121090.809
86_A135_I0.121060.809
172_S370_G0.121030.808
87_W138_M0.120780.807
127_T133_T0.120630.806
531_A534_Y0.120430.804
331_I335_Q0.120410.804
326_F454_G0.120210.803
494_L499_A0.120150.803
427_I443_T0.120010.802
60_L63_P0.119940.801
461_Y539_S0.11990.801
356_S359_G0.119860.801
113_I116_L0.119710.800
262_G467_N0.119320.797
188_L193_S0.119250.797
83_F134_F0.119210.796
411_F414_L0.11910.796
247_F251_L0.119050.795
119_V123_I0.118940.795
119_V210_L0.118760.793
395_G399_A0.118710.793
106_G109_Y0.118660.793
118_G122_S0.118640.793
402_P525_Q0.118240.790
194_G197_W0.118130.789
275_A283_L0.118040.789
79_N131_M0.117930.788
477_V523_A0.117860.787
88_T454_G0.117580.785
312_F316_L0.117550.785
386_G425_P0.117490.785
182_S186_A0.117320.784
336_Q340_V0.117060.782
87_W118_G0.116530.778
384_I551_L0.116420.778
334_P355_S0.116330.777
250_G253_L0.116310.777
117_L121_G0.1160.775
401_R404_N0.115820.774
395_G398_A0.115710.773
189_F201_I0.115640.772
523_A527_A0.115560.772
180_W356_S0.115370.771
360_F363_C0.115370.771
354_I406_N0.11490.768
86_A90_A0.114810.767
332_L535_V0.114450.765
176_I362_S0.114130.762
155_I171_A0.113880.761
275_A278_V0.113750.760
242_I245_F0.113690.759
189_F194_G0.113520.758
333_W337_V0.113490.758
336_Q532_Y0.113440.758
369_L372_L0.113240.756
154_A158_L0.113020.755
89_L252_A0.112890.754
308_D433_I0.11280.754
246_L250_G0.112780.753
212_L217_Y0.112540.752
279_I282_V0.112490.751
211_V214_F0.112480.751
393_F396_A0.112320.750
268_W273_V0.112240.750
378_H381_W0.112230.750
102_S106_G0.11220.750
494_L498_L0.112170.749
190_A345_P0.111670.746
293_F297_K0.111540.745
391_T540_I0.111470.745
217_Y220_P0.111270.743
333_W412_L0.110990.741
353_W357_P0.11090.741
183_P202_F0.110860.741
389_L418_G0.110550.738
373_F428_V0.11050.738
534_Y537_Y0.11050.738
118_G202_F0.110280.737
392_A395_G0.11020.736
468_K531_A0.109580.732
294_G297_K0.10950.731
358_V416_G0.109220.730
186_A202_F0.109180.729
93_V252_A0.109170.729
112_I213_I0.10880.727
524_F528_Y0.108780.727
299_P303_H0.108680.726
473_L527_A0.108590.725
256_L276_P0.108490.725
447_G451_S0.108330.724
172_S424_V0.108280.723
289_V294_G0.108050.722
77_S335_Q0.108040.722
312_F430_A0.107950.721
186_A352_G0.107840.720
190_A197_W0.107810.720
102_S153_L0.107760.720
119_V203_I0.107750.720
384_I388_V0.107650.719
129_Q196_R0.107440.718
183_P187_Q0.107190.716
335_Q339_N0.107070.715
292_W307_K0.107040.715
392_A414_L0.106960.715
292_W303_H0.106930.714
290_W293_F0.106760.713
329_V394_C0.106730.713
398_A533_R0.106620.712
175_F363_C0.106550.712
168_L172_S0.106480.711
210_L214_F0.106250.710
326_F419_I0.106090.709
69_Y73_D0.106080.709
271_A278_V0.106060.708
260_W263_Y0.106020.708
371_L374_S0.105950.708
88_T455_S0.105940.708
95_F451_S0.105870.707
117_L143_V0.105810.707
212_L216_F0.105720.706
71_N80_W0.105710.706
242_I246_L0.105430.704
244_I300_L0.105270.703
280_G283_L0.105270.703
88_T323_G0.105190.703
103_D441_T0.105070.702
181_I184_L0.104960.701
373_F382_Q0.104880.701
92_A452_I0.104760.700
201_I204_I0.104750.700
543_G546_A0.104570.699
530_H533_R0.104560.698
460_I542_F0.104480.698
200_Y204_I0.104470.698
365_G368_I0.104260.696
68_P351_I0.10420.696
361_G416_G0.104010.695
306_F312_F0.103980.695
373_F424_V0.103930.694
156_S431_Q0.103560.692
406_N409_I0.103550.692
360_F364_A0.103520.692
180_W362_S0.103490.691
82_W87_W0.103370.691
269_K272_H0.103260.690
120_V123_I0.103220.690
320_F456_I0.103210.689
272_H276_P0.103070.689
122_S141_Y0.102970.688
125_C206_S0.10280.687
400_V411_F0.102740.686
239_L244_I0.102710.686
465_F528_Y0.102410.684
311_G553_L0.102330.684
62_L186_A0.102280.683
323_G326_F0.102190.683
111_F209_A0.102190.683
169_A366_A0.101950.681
202_F206_S0.101880.681
369_L373_F0.101630.679
396_A399_A0.101550.678
476_Y526_E0.101340.677
274_I279_I0.101330.677
90_A142_G0.101110.675
370_G375_K0.101090.675
166_L371_L0.101060.675
277_L280_G0.1010.675
260_W273_V0.10070.673
332_L462_N0.100350.670
308_D313_A0.099930.668
187_Q199_F0.099590.665
370_G374_S0.099530.665
287_F301_F0.099380.664
303_H307_K0.099180.663
383_L550_A0.099170.662
102_S123_I0.099140.662
365_G421_G0.098860.660
421_G425_P0.098710.659
532_Y535_V0.098570.658
342_G345_P0.098350.657
368_I371_L0.098280.657
332_L335_Q0.098180.656
62_L185_I0.098150.656
211_V215_F0.097980.655
471_K474_P0.09790.654
321_I546_A0.097840.654
261_G267_P0.097590.652
189_F198_I0.097490.651
125_C141_Y0.097280.650
283_L364_A0.097260.650
109_Y112_I0.097250.650
457_G538_S0.096980.648
237_K278_V0.096880.647
122_S126_A0.096880.647
118_G199_F0.096690.646
185_I189_F0.096560.645
305_L357_P0.096540.645
62_L198_I0.096460.644
67_L71_N0.096350.644
62_L201_I0.096090.642
197_W204_I0.095770.640
545_V549_A0.095450.638
69_Y72_A0.095390.637
197_W202_F0.095370.637
354_I409_I0.095360.637
341_F354_I0.095260.636
397_M412_L0.095230.636
96_P247_F0.095050.635
178_T202_F0.094750.633
92_A168_L0.094740.633
81_S259_S0.094680.632
329_V415_A0.094610.632
270_S274_I0.094570.632
533_R537_Y0.094510.631
281_F293_F0.094450.631
111_F151_A0.094360.630
162_K166_L0.094160.629
367_V420_G0.094030.628
325_N539_S0.094010.628
198_I202_F0.0940.628
322_S390_M0.093920.627
87_W199_F0.093860.627
116_L288_V0.093680.626
368_I372_L0.093630.625
106_G157_E0.093480.624
384_I547_I0.093440.624
314_A318_I0.093280.623
107_R440_G0.093210.623
182_S195_W0.093180.622
100_R178_T0.093180.622
213_I218_F0.093020.621
420_G424_V0.093010.621
69_Y338_V0.0930.621
428_V431_Q0.092960.621
196_R200_Y0.092850.620
321_I545_V0.09280.620
397_M415_A0.092760.620
84_S88_T0.092720.619
74_I80_W0.092710.619
107_R291_E0.092620.619
332_L465_F0.092540.618
470_P474_P0.092330.617
385_F388_V0.092230.616
187_Q345_P0.092130.615
166_L369_L0.091990.615
248_I252_A0.091850.614
105_F239_L0.091570.612
537_Y540_I0.091430.611
260_W276_P0.091370.610
116_L136_A0.09130.610
96_P300_L0.091110.609
328_S539_S0.091060.608
67_L76_G0.090830.607
63_P254_F0.090820.607
173_I177_I0.09080.607
407_A410_A0.090710.606
118_G186_A0.090670.606
473_L524_F0.090580.605
68_P338_V0.090520.605
472_E527_A0.090430.604
500_A510_P0.090330.603
186_A203_I0.090310.603
91_S451_S0.090170.602
118_G141_Y0.090150.602
509_I524_F0.090040.601
190_A193_S0.089950.601
301_F306_F0.08990.601
395_G410_A0.089890.600
145_A259_S0.089880.600
343_S351_I0.089840.600
477_V526_E0.089740.599
401_R529_A0.089710.599
538_S541_A0.089650.599
253_L257_G0.089550.598
215_F218_F0.089370.597
255_L455_S0.089210.596
541_A544_V0.089120.595
129_Q211_V0.089110.595
387_S391_T0.089010.595
105_F113_I0.088880.594
281_F284_L0.088840.593
338_V444_G0.088790.593
318_I550_A0.088550.592
476_Y527_A0.088540.591
501_G510_P0.088480.591
520_V523_A0.088460.591
126_A196_R0.088460.591
362_S419_I0.088410.591
268_W277_L0.088380.590
66_I466_T0.088370.590
386_G459_A0.088340.590
162_K165_G0.08830.590
169_A370_G0.088180.589
63_P83_F0.088080.588
184_L353_W0.088080.588
411_F415_A0.088050.588
310_R343_S0.088020.588
249_A252_A0.0880.588
108_R214_F0.087990.588
426_A429_I0.087870.587
308_D434_V0.087860.587
427_I446_T0.087750.586
155_I158_L0.087610.585
358_V415_A0.087590.585
115_S419_I0.087570.585
417_F421_G0.08750.585
237_K297_K0.087470.584
153_L377_R0.087450.584
525_Q528_Y0.08740.584
337_V341_F0.087390.584
438_D441_T0.087360.584
120_V551_L0.087340.583
154_A209_A0.087310.583
137_G140_L0.087210.583
500_A509_I0.087170.582
126_A197_W0.087150.582
165_G299_P0.087030.581
100_R104_L0.0870.581
102_S157_E0.086950.581
184_L359_G0.086920.581
92_A448_S0.086920.581
176_I366_A0.08680.580
399_A407_A0.086770.580
360_F413_V0.086730.579
415_A419_I0.086710.579
186_A204_I0.086670.579
125_C199_F0.086620.579
99_G103_D0.08660.578
280_G533_R0.086590.578
306_F323_G0.086530.578
100_R298_D0.086450.577
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1pw4A0.73621000.627
4j05A0.80631000.629
4apsA0.7781000.645
3o7qA0.67781000.672
4jr9A0.68611000.686
2gfpA0.61771000.689
4iu9B0.69621000.689
2xutA0.78961000.692
4gc0A0.74961000.7
2cfqA0.679599.90.752
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