GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Sm_multidrug_ex - Putative small multi-drug export protein
Pfam: PF06695 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 121
Sequences: 5607
Seq/Len: 46.34
HH_delta: 0.902 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
32_P104_K1.411133.207
103_D106_K1.187272.699
15_P18_E1.140842.593
74_F110_A1.04582.377
28_I112_F0.908912.066
16_P20_F0.819651.863
72_Y75_W0.805461.831
32_P108_F0.803091.825
34_I95_L0.788741.793
66_S70_E0.777171.766
15_P19_A0.749951.705
24_F116_L0.742231.687
36_L40_K0.738471.679
81_V111_I0.734341.669
78_A113_L0.708981.611
43_K66_S0.685251.558
63_E67_K0.667361.517
104_K108_F0.659481.499
105_K109_L0.65831.496
14_L19_A0.65771.495
18_E22_L0.651061.480
39_D101_G0.635731.445
80_F93_G0.633831.441
75_W79_L0.618371.406
38_L98_S0.617581.404
36_L104_K0.61431.396
74_F106_K0.60381.372
38_L99_L0.602361.369
42_L46_K0.581751.322
22_L26_G0.570061.296
31_V111_I0.559141.271
20_F24_F0.558121.269
27_N115_V0.542361.233
59_E63_E0.533331.212
17_W20_F0.531721.209
18_E21_L0.523491.190
35_L107_A0.516681.174
66_S100_L0.507261.153
63_E66_S0.502041.141
17_W21_L0.500011.136
110_A114_G0.492871.120
28_I108_F0.484711.102
35_L38_L0.474511.079
32_P36_L0.466911.061
43_K47_R0.458511.042
78_A110_A0.458151.041
81_V115_V0.457111.039
24_F28_I0.450151.023
68_K76_G0.434480.988
61_K64_K0.433970.986
82_A117_I0.433410.985
21_L25_L0.427230.971
108_F112_F0.426510.969
67_K70_E0.422520.960
24_F112_F0.42130.958
77_L110_A0.415470.944
24_F115_V0.413580.940
28_I115_V0.412240.937
78_A117_I0.410670.933
94_A111_I0.407720.927
106_K110_A0.400720.911
74_F102_M0.396990.902
111_I115_V0.386740.879
76_G80_F0.372830.847
36_L39_D0.372580.847
46_K55_Y0.364590.829
113_L116_L0.363790.827
42_L45_L0.361610.822
97_A102_M0.352890.802
98_S107_A0.351240.798
106_K109_L0.350130.796
60_K64_K0.348210.791
81_V85_L0.345390.785
44_W47_R0.344720.784
64_K68_K0.342550.779
33_F36_L0.342290.778
81_V94_A0.33960.772
31_V81_V0.337540.767
35_L98_S0.330730.752
113_L117_I0.330220.751
81_V114_G0.329660.749
21_L24_F0.329270.748
115_V118_A0.328880.748
43_K46_K0.327480.744
109_L113_L0.327410.744
27_N31_V0.326040.741
37_F41_I0.325660.740
55_Y59_E0.322570.733
67_K71_K0.322140.732
80_F84_P0.312140.709
69_I73_G0.311780.709
35_L39_D0.310540.706
64_K67_K0.310480.706
47_R59_E0.308780.702
31_V107_A0.306790.697
69_I97_A0.306680.697
42_L98_S0.305460.694
40_K44_W0.303220.689
23_A27_N0.300780.684
34_I94_A0.30020.682
22_L25_L0.299170.680
77_L102_M0.298930.679
68_K71_K0.296770.675
109_L112_F0.29480.670
35_L104_K0.291750.663
78_A114_G0.289040.657
31_V94_A0.288990.657
13_G19_A0.286020.650
39_D98_S0.285780.650
23_A34_I0.282890.643
94_A114_G0.279920.636
63_E101_G0.279770.636
31_V114_G0.278620.633
13_G16_P0.277530.631
65_K100_L0.277460.631
34_I38_L0.275720.627
41_I44_W0.274180.623
107_A111_I0.274170.623
82_A85_L0.273480.622
34_I92_T0.272450.619
31_V77_L0.271660.617
93_G97_A0.270430.615
23_A26_G0.269870.613
79_L83_I0.266650.606
26_G30_P0.266540.606
14_L23_A0.264040.600
76_G93_G0.263610.599
65_K118_A0.262740.597
112_F116_L0.261940.595
29_L32_P0.259980.591
31_V34_I0.259810.591
43_K101_G0.259140.589
60_K63_E0.255010.580
66_S96_I0.254340.578
66_S101_G0.253220.576
34_I37_F0.251590.572
30_P34_I0.249950.568
19_A27_N0.249630.567
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2jlnA0.8439.70.902
4hw9A0.83478.50.905
3w4tA0.45456.20.91
4gc0A0.53724.20.917
4apsA0.47113.30.92
2v50A0.52073.10.922
1fftA0.57022.70.923
4humA0.46282.70.924
3spcA0.50412.30.926
3o5vA0.46282.30.926
If you are interested in a protein containing this domain,
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