GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF1206 - Domain of Unknown Function (DUF1206)
Pfam: PF06724 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 73
Sequences: 502
Seq/Len: 6.88
HH_delta: 0.862 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
31_Q35_G0.348892.568
62_I66_V0.277012.039
47_R51_G0.224851.655
15_G22_A0.224591.653
37_L50_L0.216621.595
60_Y64_Q0.216051.590
9_I28_S0.212151.562
53_V56_G0.200461.476
48_W51_G0.194031.428
7_R11_Y0.188081.385
7_R17_L0.187581.381
19_L56_G0.184381.357
40_L43_Q0.183181.348
2_I35_G0.178761.316
16_Y20_Q0.178531.314
66_V70_Y0.174251.283
56_G60_Y0.174061.281
9_I52_A0.17131.261
56_G59_G0.170731.257
17_L36_A0.16591.221
16_Y28_S0.157561.160
11_Y18_A0.157341.158
29_S57_L0.156581.153
33_S63_W0.155811.147
1_R12_G0.153291.128
7_R71_R0.151531.115
3_G8_G0.151371.114
12_G35_G0.150221.106
1_R11_Y0.149911.104
4_Y71_R0.146951.082
58_I61_G0.146331.077
1_R14_L0.146251.077
27_G69_V0.144921.067
5_A27_G0.143831.059
65_F69_V0.143291.055
17_L31_Q0.142291.047
6_A56_G0.139841.029
4_Y45_F0.137621.013
22_A35_G0.134860.993
10_V55_L0.133310.981
21_A32_G0.133060.980
24_G52_A0.13270.977
43_Q49_L0.131740.970
17_L21_A0.130540.961
55_L59_G0.129870.956
15_G21_A0.129320.952
4_Y40_L0.129310.952
5_A55_L0.129070.950
42_E47_R0.128810.948
58_I62_I0.128250.944
21_A30_D0.127380.938
2_I54_G0.126660.932
15_G26_G0.126430.931
19_L23_L0.126370.930
18_A48_W0.124720.918
32_G64_Q0.124520.917
34_Q41_L0.124390.916
67_K73_F0.12420.914
60_Y65_F0.123720.911
1_R5_A0.122930.905
17_L54_G0.12290.905
14_L33_S0.122440.901
13_A72_R0.122260.900
5_A8_G0.121920.897
2_I10_V0.121830.897
64_Q71_R0.120590.888
6_A55_L0.120320.886
8_G12_G0.120050.884
38_A69_V0.118110.869
38_A42_E0.117850.868
6_A72_R0.117690.866
35_G38_A0.116140.855
10_V63_W0.115320.849
63_W67_K0.111780.823
66_V72_R0.111720.822
4_Y68_A0.110990.817
17_L43_Q0.110450.813
5_A67_K0.109050.803
15_G54_G0.109010.802
11_Y14_L0.108380.798
2_I6_A0.108010.795
9_I57_L0.106120.781
9_I51_G0.105870.779
12_G16_Y0.105850.779
11_Y71_R0.105760.779
59_G70_Y0.105720.778
37_L56_G0.104420.769
54_G58_I0.103710.763
16_Y42_E0.103370.761
3_G63_W0.103180.760
4_Y63_W0.103140.759
34_Q57_L0.103130.759
21_A60_Y0.102530.755
60_Y71_R0.101550.748
47_R54_G0.101180.745
43_Q50_L0.100780.742
31_Q36_A0.100520.740
10_V54_G0.100440.739
23_L47_R0.100020.736
11_Y33_S0.099770.734
62_I70_Y0.099690.734
16_Y36_A0.099650.734
62_I73_F0.099590.733
55_L66_V0.098390.724
1_R53_V0.098270.723
54_G71_R0.097560.718
3_G68_A0.096960.714
37_L68_A0.096910.713
48_W52_A0.096850.713
18_A65_F0.096650.711
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
1rz2A0.547912.10.862
2f93B0.93155.70.88
3fwmA0.57535.20.882
2bs2C0.97263.60.89
4k1cA0.972630.894
2kncB0.57532.90.895
2lomA0.76712.80.896
3fpnA0.63012.50.898
1h2sB0.80822.40.899
4kjsA0.97262.10.902
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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