GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF1212 - Protein of unknown function (DUF1212)
Pfam: PF06738 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0470
Length: 193
Sequences: 1148
Seq/Len: 5.95
HH_delta: 0.933 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
76_R90_R0.381383.800
111_G136_L0.332763.316
90_R93_E0.290232.892
73_L94_I0.227052.262
26_L77_I0.220032.192
115_A132_F0.219142.183
83_S86_E0.201392.007
114_S135_G0.200381.997
102_P105_L0.194741.940
2_G40_I0.191341.906
111_G132_F0.188311.876
2_G19_M0.187931.872
77_I87_A0.186721.860
71_N75_R0.185741.851
18_T74_S0.183641.830
5_L10_A0.178871.782
118_A123_G0.178381.777
117_F188_M0.175961.753
124_S127_D0.163431.628
1_L18_T0.162671.621
134_L166_L0.161191.606
71_N74_S0.158511.579
19_M33_V0.156111.555
70_V91_L0.149461.489
14_R127_D0.146061.455
41_F54_V0.143161.426
1_L91_L0.14091.404
137_L162_L0.139371.389
73_L87_A0.139241.387
1_L70_V0.138781.383
69_A97_E0.138651.381
11_E16_E0.136411.359
3_R55_R0.135451.350
108_L132_F0.134511.340
127_D178_S0.134271.338
3_R7_E0.131671.312
18_T71_N0.131331.309
72_R76_R0.13111.306
86_E90_R0.129541.291
138_V189_P0.129061.286
188_M191_V0.127021.266
107_I136_L0.126111.257
110_A139_G0.125871.254
135_G139_G0.125821.254
111_G115_A0.125731.253
127_D176_P0.124371.239
110_A135_G0.123371.229
80_G87_A0.123271.228
19_M42_I0.121131.207
22_I74_S0.120941.205
163_A189_P0.120941.205
18_T21_R0.119031.186
52_T120_L0.118781.184
4_A70_V0.118631.182
101_Y105_L0.118251.178
83_S164_S0.11781.174
28_L44_F0.117441.170
14_R74_S0.116941.165
17_D21_R0.116941.165
34_F39_G0.11681.164
1_L74_S0.116761.163
10_A71_N0.11471.143
4_A95_D0.112971.126
134_L190_L0.112411.120
18_T75_R0.112321.119
16_E56_R0.111981.116
21_R74_S0.111211.108
134_L182_V0.111011.106
83_S89_E0.11051.101
11_E71_N0.110041.096
115_A119_L0.109761.094
2_G17_D0.109531.091
76_R82_L0.10921.088
103_P143_Q0.10921.088
144_L147_R0.109161.088
118_A185_G0.108771.084
76_R81_Q0.108311.079
63_N66_K0.108241.078
105_L125_W0.108171.078
89_E93_E0.108071.077
1_L22_I0.107651.073
86_E89_E0.10741.070
65_D69_A0.106881.065
115_A128_M0.106691.063
82_L87_A0.106341.060
77_I82_L0.106211.058
39_G54_V0.105791.054
31_V42_I0.105111.047
174_G177_F0.105031.046
6_L15_V0.103361.030
143_Q147_R0.103071.027
171_A175_P0.103031.027
13_Y16_E0.102541.022
130_V170_L0.102381.020
135_G184_I0.100851.005
116_A131_A0.100831.005
6_L56_R0.100180.998
114_S188_M0.099510.991
23_A31_V0.098280.979
170_L182_V0.097580.972
73_L161_F0.097440.971
20_Q58_P0.09710.967
43_S52_T0.09680.964
113_A186_A0.096260.959
138_V157_F0.096190.958
16_E37_P0.095920.956
134_L138_V0.095530.952
22_I77_I0.095360.950
4_A19_M0.095140.948
138_V163_A0.094940.946
85_E90_R0.094380.940
110_A138_V0.094370.940
93_E160_A0.094230.939
165_L177_F0.093990.936
122_G128_M0.093730.934
21_R71_N0.093360.930
140_L144_L0.092950.926
80_G93_E0.09270.924
36_T43_S0.092690.924
126_I129_I0.092440.921
17_D75_R0.092340.920
92_D169_L0.092320.920
35_V38_T0.092180.918
5_L180_S0.092070.917
10_A61_G0.092050.917
82_L86_E0.089470.891
16_E192_P0.08940.891
166_L170_L0.089090.888
141_L162_L0.0890.887
38_T118_A0.088980.887
178_S191_V0.088580.883
4_A66_K0.088030.877
60_R183_I0.08780.875
17_D185_G0.087210.869
89_E162_L0.08720.869
114_S142_R0.087130.868
127_D182_V0.087050.867
129_I132_F0.08690.866
11_E75_R0.086620.863
13_Y37_P0.086590.863
66_K94_I0.086560.862
67_L189_P0.086190.859
56_R117_F0.086110.858
133_I166_L0.085920.856
34_F56_R0.085850.855
83_S96_R0.085690.854
108_L141_L0.085660.853
33_V42_I0.085590.853
22_I42_I0.085320.850
180_S185_G0.085320.850
140_L147_R0.08520.849
80_G189_P0.08490.846
12_T37_P0.084720.844
124_S170_L0.084660.844
59_P96_R0.084640.843
113_A117_F0.084580.843
8_S160_A0.084530.842
48_G166_L0.084410.841
104_W107_I0.084280.840
181_A185_G0.08410.838
62_V188_M0.083950.836
16_E64_L0.083720.834
31_V94_I0.083580.833
28_L107_I0.083520.832
72_R90_R0.083240.829
138_V142_R0.083070.828
6_L38_T0.083020.827
38_T60_R0.082750.825
83_S177_F0.082690.824
11_E18_T0.082590.823
96_R108_L0.082170.819
79_A89_E0.082120.818
169_L173_L0.081960.817
40_I49_E0.081780.815
12_T71_N0.081360.811
71_N189_P0.081320.810
83_S97_E0.081120.808
85_E108_L0.080980.807
21_R27_G0.080920.806
115_A131_A0.080670.804
82_L98_P0.080590.803
108_L173_L0.080530.802
7_E73_L0.080480.802
65_D97_E0.080450.802
73_L77_I0.080350.801
107_I139_G0.080170.799
161_F164_S0.079910.796
123_G131_A0.079880.796
161_F168_A0.079810.795
18_T67_L0.079580.793
86_E129_I0.079540.793
150_L165_L0.079320.790
45_D97_E0.079250.790
164_S179_P0.079070.788
12_T69_A0.078970.787
125_W133_I0.078750.785
184_I188_M0.078630.783
57_V186_A0.078550.783
24_R129_I0.078430.781
5_L32_E0.078410.781
16_E185_G0.07770.774
8_S113_A0.077590.773
6_L104_W0.077440.772
113_A188_M0.077410.771
52_T162_L0.077360.771
79_A175_P0.077240.770
52_T55_R0.077220.769
154_I184_I0.076990.767
14_R113_A0.076720.764
137_L158_I0.076510.762
84_L88_I0.076130.759
21_R75_R0.07610.758
160_A190_L0.076050.758
4_A77_I0.075950.757
77_I154_I0.075910.756
1_L4_A0.075890.756
79_A129_I0.07580.755
23_A76_R0.075730.755
32_E154_I0.075670.754
156_E161_F0.075560.753
52_T69_A0.075520.752
133_I137_L0.075520.752
11_E117_F0.075440.752
68_A72_R0.075380.751
4_A91_L0.075080.748
9_G186_A0.075030.748
29_E158_I0.075020.747
58_P73_L0.075010.747
167_A182_V0.074870.746
89_E161_F0.074830.746
35_V40_I0.074710.744
7_E189_P0.074540.743
106_V134_L0.074520.743
104_W108_L0.07450.742
160_A163_A0.074430.742
141_L159_A0.074390.741
59_P63_N0.07430.740
28_L100_R0.074260.740
57_V179_P0.074240.740
25_A78_V0.074240.740
32_E53_R0.074230.740
52_T185_G0.074080.738
141_L174_G0.074010.737
156_E192_P0.073960.737
96_R133_I0.073930.737
71_N188_M0.073650.734
137_L165_L0.073610.733
42_I146_S0.073440.732
8_S60_R0.07330.730
27_G54_V0.073180.729
5_L53_R0.073160.729
14_R67_L0.073040.728
1_L82_L0.072980.727
36_T135_G0.072940.727
142_R156_E0.07290.726
64_L73_L0.072860.726
89_E133_I0.072780.725
56_R64_L0.072740.725
34_F184_I0.072630.724
89_E96_R0.072550.723
125_W128_M0.072510.722
130_V134_L0.072460.722
105_L116_A0.072310.720
96_R150_L0.072270.720
12_T78_V0.072240.720
103_P166_L0.072220.720
47_D158_I0.072170.719
76_R97_E0.072120.719
51_R94_I0.072120.719
102_P147_R0.071990.717
130_V175_P0.071950.717
93_E137_L0.071870.716
84_L165_L0.071760.715
85_E89_E0.07170.714
184_I187_I0.071650.714
86_E133_I0.071610.714
89_E175_P0.071460.712
8_S66_K0.071450.712
89_E172_R0.071430.712
92_D162_L0.071190.709
26_L87_A0.070950.707
11_E17_D0.070820.706
29_E52_T0.070770.705
55_R190_L0.070760.705
28_L32_E0.070590.703
11_E34_F0.070580.703
125_W148_R0.070520.703
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3rfuA0.77244.20.933
3qe7A0.518137.40.935
4jkvA0.937828.40.939
3hd7B0.4404280.939
3b8cA0.704724.10.941
1rfzA0.699523.80.941
3ucsA0.461119.50.943
4bduA0.430117.10.944
4dveA0.704716.40.945
2nwlA0.528515.90.945
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

Page generated in 0.0396 seconds.