GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Put_Phosphatase - Putative Phosphatase
Pfam: PF06888 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0137
Length: 234
Sequences: 5291
Seq/Len: 22.61
HH_delta: 0.356 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
176_G181_D0.84633.343
96_S103_I0.762653.013
91_D117_S0.761513.008
77_K81_R0.73162.890
185_A193_V0.697272.754
100_S104_E0.668312.640
108_E113_R0.655832.591
81_R115_C0.613842.425
86_N117_S0.558582.207
157_R161_E0.536492.119
93_I118_E0.532342.103
168_P171_R0.52542.075
92_L116_F0.519542.052
159_L172_V0.499321.972
5_F92_L0.478311.889
10_T181_D0.465981.841
7_F12_V0.465751.840
3_V175_I0.454261.794
2_L167_V0.437731.729
183_C187_R0.435651.721
157_R160_Q0.434951.718
3_V83_L0.431111.703
4_V95_I0.427781.690
81_R87_Q0.423831.674
137_Y153_K0.421551.665
104_E108_E0.41561.642
3_V90_F0.407941.611
7_F94_I0.404271.597
7_F103_I0.38481.520
159_L169_Y0.379391.499
86_N115_C0.374791.481
153_K157_R0.371281.467
75_G78_E0.370231.463
153_K156_E0.364671.441
174_Y184_P0.363571.436
78_E81_R0.361721.429
19_W22_E0.359441.420
83_L90_F0.356681.409
103_I121_T0.356051.406
82_F88_R0.351461.388
182_F193_V0.349051.379
173_I194_V0.33981.342
174_Y185_A0.338781.338
100_S124_A0.338371.337
155_L176_G0.33531.325
167_V172_V0.333961.319
185_A192_D0.332461.313
95_I154_I0.325751.287
61_E65_D0.317631.255
159_L190_P0.312221.233
86_N92_L0.304771.204
100_S121_T0.304411.203
104_E113_R0.303331.198
44_E47_D0.302481.195
172_V190_P0.302161.194
19_W23_L0.301741.192
120_F158_L0.299221.182
174_Y181_D0.299061.181
75_G79_L0.298661.180
5_F11_I0.298411.179
95_I174_Y0.296351.171
8_D177_D0.295821.169
8_D14_Q0.29521.166
100_S123_P0.292261.155
72_I77_K0.286191.131
44_E48_R0.285431.128
179_R183_C0.285351.127
183_C186_L0.28441.123
82_F87_Q0.284241.123
48_R52_L0.282941.118
32_E36_S0.277411.096
31_E35_E0.276851.094
13_D71_P0.276541.092
118_E161_E0.275971.090
4_V93_I0.274441.084
8_D98_A0.274111.083
93_I162_Q0.272861.078
184_P188_L0.270911.070
7_F11_I0.269741.066
105_T109_H0.268311.060
11_I76_M0.267651.057
2_L172_V0.267221.056
62_D65_D0.265271.048
6_D177_D0.263371.040
73_D198_K0.262961.039
73_D76_M0.252810.999
32_E35_E0.251220.992
34_R38_P0.249650.986
156_E160_Q0.247390.977
22_E28_E0.244690.967
48_R51_Q0.240550.950
59_T62_D0.237820.939
180_N183_C0.237040.936
158_L162_Q0.236680.935
4_V190_P0.235910.932
155_L181_D0.234810.928
47_D51_Q0.233850.924
120_F161_E0.233640.923
4_V158_L0.232250.917
97_D174_Y0.231470.914
121_T124_A0.23090.912
156_E169_Y0.229450.906
105_T108_E0.226640.895
8_D176_G0.225890.892
155_L190_P0.225780.892
174_Y190_P0.224930.889
160_Q170_D0.222720.880
83_L175_I0.22240.879
17_D70_I0.221270.874
13_D73_D0.220610.871
120_F157_R0.220180.870
79_L175_I0.21940.867
3_V173_I0.21890.865
180_N184_P0.217880.861
10_T176_G0.217120.858
7_F98_A0.216880.857
80_L115_C0.216260.854
156_E187_R0.214760.848
95_I120_F0.213790.845
107_L111_G0.213170.842
81_R114_D0.212710.840
174_Y180_N0.212710.840
5_F79_L0.212040.838
72_I112_L0.211570.836
4_V172_V0.211140.834
78_E82_F0.210260.831
155_L184_P0.210210.830
8_D11_I0.209120.826
5_F83_L0.208560.824
20_V24_L0.207660.820
23_L62_D0.204780.809
2_L91_D0.204070.806
111_G114_D0.203580.804
122_N176_G0.203540.804
60_P64_R0.203090.802
7_F106_I0.200610.792
156_E159_L0.200350.791
175_I194_V0.19940.788
107_L112_L0.198630.785
120_F124_A0.197790.781
21_I26_P0.196350.776
185_A190_P0.195280.771
8_D96_S0.195170.771
102_F106_I0.193980.766
103_I106_I0.192210.759
12_V106_I0.191850.758
162_Q167_V0.19130.756
80_L116_F0.191110.755
6_D10_T0.189830.750
9_H15_D0.189430.748
33_L36_S0.188330.744
18_D22_E0.187660.741
103_I107_L0.187240.740
116_F119_I0.186930.738
77_K114_D0.186510.737
96_S121_T0.18650.737
86_N114_D0.186380.736
156_E188_L0.185550.733
76_M79_L0.185440.733
71_P74_P0.184620.729
112_L115_C0.184570.729
23_L26_P0.183630.725
15_D178_G0.183570.725
10_T177_D0.183190.724
7_F10_T0.183090.723
92_L115_C0.182480.721
197_R203_H0.182230.720
65_D68_R0.181690.718
16_S71_P0.181560.717
79_L82_F0.18090.715
94_I107_L0.180550.713
97_D176_G0.180550.713
178_G188_L0.180270.712
193_V196_P0.180260.712
5_F116_F0.179540.709
9_H12_V0.178750.706
29_L32_E0.177760.702
31_E34_R0.176210.696
103_I119_I0.174290.688
94_I116_F0.174060.688
182_F195_F0.173160.684
38_P45_Y0.172330.681
25_P28_E0.171960.679
181_D184_P0.171550.678
101_F104_E0.17090.675
45_Y97_D0.170620.674
21_I24_L0.17050.674
173_I193_V0.17020.672
79_L83_L0.170130.672
14_Q98_A0.170080.672
178_G181_D0.169420.669
50_L63_I0.1690.668
83_L92_L0.168850.667
43_T47_D0.16770.662
7_F158_L0.167480.662
108_E114_D0.165770.655
167_V171_R0.165770.655
81_R86_N0.165650.654
96_S123_P0.165590.654
174_Y178_G0.165450.654
40_G45_Y0.165340.653
11_I94_I0.165310.653
99_N102_F0.165280.653
6_D181_D0.165150.652
11_I80_L0.164950.652
98_A181_D0.16480.651
76_M198_K0.164260.649
154_I188_L0.163360.645
166_G170_D0.163020.644
5_F175_I0.162880.643
36_S39_K0.162620.642
169_Y188_L0.161740.639
42_W45_Y0.16160.638
47_D50_L0.161430.638
154_I158_L0.160650.635
2_L90_F0.160240.633
177_D180_N0.159880.632
3_V92_L0.159120.629
9_H14_Q0.157550.622
12_V103_I0.157280.621
95_I98_A0.157210.621
155_L158_L0.156660.619
8_D95_I0.156070.617
30_P33_L0.155930.616
93_I120_F0.155390.614
175_I181_D0.155150.613
184_P190_P0.154210.609
34_R39_K0.15290.604
181_D199_G0.152830.604
93_I158_L0.152310.602
77_K111_G0.152250.601
87_Q168_P0.152250.601
50_L53_L0.151980.600
51_Q54_H0.151760.599
28_E52_L0.151520.599
4_V155_L0.150540.595
2_L93_I0.150320.594
176_G180_N0.150140.593
169_Y190_P0.150110.593
154_I198_K0.149860.592
22_E87_Q0.149280.590
41_G67_L0.149140.589
77_K115_C0.147950.584
64_R101_F0.147680.583
6_D11_I0.147350.582
74_P77_K0.146510.579
181_D188_L0.146310.578
5_F136_P0.145550.575
97_D155_L0.145320.574
98_A176_G0.144280.570
98_A102_F0.144180.570
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3kbbA0.863299.90.356
3qxgA0.85999.90.365
2ah5A0.837699.90.368
4ex6A0.863299.90.379
3dv9A0.85999.90.38
4eekA0.863299.90.388
3s6jA0.863299.90.388
2hszA0.854799.90.392
3mc1A0.867599.90.396
2pibA0.850499.90.398

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