GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF1292 - Protein of unknown function (DUF1292)
Pfam: PF06949 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 76
Sequences: 624
Seq/Len: 8.21
HH_delta: 0.854 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
19_K42_K0.388582.600
24_L41_F0.37222.490
60_D64_E0.333642.232
63_F67_S0.281141.881
23_V70_Y0.263091.760
67_S71_E0.244661.637
15_E20_E0.22111.479
1_E60_D0.218811.464
17_D65_M0.213741.430
14_F54_L0.208191.393
47_D50_G0.205541.375
68_E72_E0.196591.315
21_Y58_E0.19641.314
46_E50_G0.192891.291
43_V70_Y0.18981.270
9_E27_V0.188761.263
18_G50_G0.176951.184
23_V40_I0.176871.183
12_D73_L0.176321.180
23_V66_V0.175111.172
10_V13_E0.172191.152
6_H70_Y0.170471.141
57_I63_F0.169851.136
8_F24_L0.167131.118
5_E48_E0.165411.107
23_V38_V0.164951.104
10_V20_E0.161921.083
65_M68_E0.161151.078
11_L70_Y0.160671.075
65_M69_A0.160421.073
35_D75_E0.158911.063
43_V46_E0.157741.055
60_D63_F0.153581.028
5_E20_E0.152331.019
57_I66_V0.149471.000
42_K62_E0.148480.993
14_F22_I0.146490.980
2_D5_E0.146490.980
14_F70_Y0.145850.976
8_F59_D0.145840.976
22_I70_Y0.14250.953
18_G40_I0.141870.949
27_V49_D0.14130.945
43_V52_E0.140470.940
62_E66_V0.140420.939
16_V69_A0.138660.928
24_L39_Y0.138490.927
10_V55_E0.137810.922
68_E71_E0.136060.910
69_A72_E0.136050.910
8_F27_V0.134670.901
12_D69_A0.134260.898
39_Y42_K0.133920.896
13_E43_V0.13160.880
21_Y57_I0.131030.877
56_P66_V0.129210.864
26_P72_E0.129160.864
54_L63_F0.128780.862
47_D51_E0.127160.851
46_E49_D0.126180.844
23_V56_P0.125240.838
4_N74_L0.123760.828
11_L73_L0.123470.826
40_I67_S0.122490.820
13_E20_E0.120510.806
11_L22_I0.118060.790
63_F66_V0.117930.789
55_E59_D0.117710.788
6_H53_E0.117390.785
13_E40_I0.117320.785
22_I68_E0.11710.783
19_K60_D0.116610.780
46_E53_E0.116360.779
1_E55_E0.116330.778
12_D23_V0.116160.777
15_E18_G0.115730.774
40_I47_D0.113910.762
49_D55_E0.113890.762
14_F23_V0.113770.761
12_D63_F0.112210.751
10_V43_V0.112090.750
52_E68_E0.112090.750
10_V22_I0.110180.737
70_Y73_L0.110010.736
67_S72_E0.110010.736
12_D16_V0.10960.733
26_P52_E0.109490.733
24_L71_E0.109050.730
36_G50_G0.108590.727
1_E18_G0.10840.725
20_E25_V0.107960.722
38_V43_V0.107720.721
56_P65_M0.107380.718
19_K56_P0.107040.716
28_D51_E0.106480.712
23_V74_L0.105570.706
21_Y66_V0.105430.705
5_E43_V0.104980.702
48_E53_E0.104560.700
14_F21_Y0.102320.685
25_V61_E0.101590.680
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
1jalA0.46059.60.854
2dbyA0.46059.50.854
1ni3A0.47379.40.854
4ic7E0.89478.30.858
2ohfA0.55263.20.882
2nptA0.89472.70.885
1ah9A0.53951.80.896
3fssA0.34211.10.906
2h36X0.43421.10.907
3k6mA0.89471.10.907
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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