GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
FPN1 - Ferroportin1 (FPN1)
Pfam: PF06963 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0015
Length: 432
Sequences: 52865
Seq/Len: 122.37
HH_delta: 0.232 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
104_W108_A2.412954.686
50_S114_I1.664223.232
107_I111_A1.552433.015
105_L108_A1.515922.944
67_R138_V1.455412.826
291_S294_V1.370322.661
385_V393_V1.341622.605
106_F110_F1.325712.575
58_V122_L1.323172.570
146_A149_R1.268782.464
36_S39_P1.261762.450
68_L72_R1.257562.442
143_D146_A1.256822.441
148_A318_K1.250692.429
54_F118_A1.212412.354
63_D391_G1.202062.334
140_A150_M1.198052.327
386_P389_E1.119082.173
176_A180_I1.097012.130
79_N189_N1.08772.112
46_V114_I1.05232.044
74_S122_L1.040472.021
39_P106_F1.03452.009
86_C183_I0.984061.911
321_G324_R0.98391.911
84_A112_L0.971031.886
66_P69_K0.961041.866
60_R64_R0.920951.788
50_S54_F0.919831.786
253_R257_R0.918531.784
54_F121_R0.913641.774
46_V110_F0.907611.763
108_A112_L0.899541.747
322_L383_E0.880541.710
35_G106_F0.863341.677
144_P147_L0.85661.664
315_W319_R0.856131.663
81_S112_L0.853211.657
314_P318_K0.849171.649
65_S70_V0.836861.625
85_S112_L0.831031.614
43_Y109_L0.827651.607
290_Y294_V0.822851.598
69_K73_T0.808521.570
61_W65_S0.802861.559
81_S85_S0.801151.556
309_G368_I0.800511.555
183_I187_G0.80011.554
35_G39_P0.783121.521
81_S115_L0.766891.489
316_L320_I0.761511.479
62_I126_A0.749561.456
27_L30_I0.748391.453
107_I110_F0.746541.450
177_S180_I0.745851.448
62_I67_R0.743771.444
312_V315_W0.736311.430
309_G312_V0.735671.429
65_S69_K0.729231.416
251_G254_T0.727621.413
149_R318_K0.723241.405
357_Y361_G0.714131.387
171_L175_F0.707481.374
54_F57_W0.706181.371
61_W70_V0.698391.356
66_P70_V0.698381.356
269_L404_F0.692751.345
305_F364_A0.690811.342
59_G63_D0.687031.334
294_V297_I0.682991.326
59_G391_G0.677281.315
324_R328_W0.67381.309
305_F309_G0.670831.303
140_A143_D0.660471.283
198_F202_R0.657431.277
69_K72_R0.652691.268
63_D392_A0.651261.265
174_T293_S0.648891.260
323_V327_L0.647211.257
137_V147_L0.645541.254
82_V86_C0.643411.249
329_S372_S0.643061.249
324_R327_L0.642611.248
172_L180_I0.636621.236
332_W369_G0.633861.231
47_R120_E0.631161.226
50_S117_G0.630851.225
17_G20_M0.624841.213
389_E392_A0.62461.213
29_L40_V0.624321.212
286_K292_P0.621051.206
72_R197_Y0.62031.205
284_Y288_Q0.614261.193
258_Q262_L0.608431.182
42_I46_V0.608261.181
41_S45_L0.606531.178
63_D67_R0.605141.175
49_L406_L0.605011.175
256_F262_L0.604671.174
70_V73_T0.602531.170
149_R153_T0.602111.169
52_I399_S0.601371.168
57_W60_R0.601281.168
180_I183_I0.599451.164
167_L300_G0.595491.156
111_A115_L0.595321.156
72_R193_V0.593331.152
261_F265_F0.590551.147
179_V183_I0.591.146
260_V263_A0.588591.143
361_G365_L0.587671.141
74_S119_I0.587371.141
186_A190_L0.586561.139
246_R249_I0.585491.137
259_P263_A0.583571.133
387_E390_R0.58331.133
311_W315_W0.582421.131
167_L171_L0.581921.130
315_W318_K0.581551.129
138_V390_R0.577811.122
335_V339_L0.577671.122
404_F408_S0.577561.122
194_F198_F0.576921.120
259_P262_L0.576611.120
313_Y372_S0.576611.120
308_L312_V0.57371.114
27_L31_S0.573281.113
285_L290_Y0.571761.110
83_A87_A0.570351.108
283_A287_S0.566811.101
147_L383_E0.563491.094
286_K295_I0.562991.093
159_L306_G0.562411.092
39_P110_F0.562051.091
293_S297_I0.561791.091
265_F400_L0.561341.090
113_L117_G0.559731.087
210_L213_K0.557681.083
108_A111_A0.556171.080
321_G325_A0.552961.074
320_I324_R0.552521.073
81_S119_I0.552511.073
320_I325_A0.551851.072
52_I406_L0.551331.071
304_V308_L0.550771.070
76_V193_V0.549621.067
47_R117_G0.546471.061
249_I253_R0.544341.057
254_T257_R0.543631.056
73_T76_V0.541791.052
308_L311_W0.541411.051
379_Q383_E0.538731.046
327_L331_W0.537531.044
72_R76_V0.536781.042
360_L364_A0.536241.041
381_M397_Q0.535181.039
209_A213_K0.534241.037
80_L84_A0.533921.037
328_W331_W0.533351.036
334_W338_A0.532471.034
187_G191_A0.532271.034
45_L406_L0.53051.030
302_G367_R0.526531.023
357_Y360_L0.526061.022
283_A286_K0.52571.021
24_A173_M0.525411.020
297_I301_L0.524751.019
248_I251_G0.523011.016
327_L330_L0.522431.015
104_W107_I0.520221.010
140_A146_A0.517541.005
170_G296_G0.516361.003
46_V50_S0.511360.993
127_N130_A0.510940.992
325_A328_W0.510930.992
81_S116_L0.510740.992
183_I186_A0.509510.989
190_L194_F0.507370.985
331_W335_V0.506070.983
83_A186_A0.50330.977
79_N83_A0.500090.971
262_L266_A0.499440.970
210_L214_K0.499010.969
43_Y106_F0.498190.967
256_F259_P0.498080.967
122_L126_A0.494920.961
79_N193_V0.494490.960
382_Q394_S0.491430.954
356_A360_L0.487970.948
84_A87_A0.487290.946
256_F260_V0.486850.945
28_F178_P0.48640.945
312_V316_L0.485530.943
60_R392_A0.484940.942
56_P60_R0.484680.941
51_A402_S0.483740.939
111_A114_I0.48340.939
55_G398_N0.483210.938
268_A397_Q0.482930.938
260_V264_S0.480450.933
19_R162_K0.480030.932
372_S376_A0.479510.931
149_R315_W0.478070.928
258_Q261_F0.476580.926
151_N382_Q0.476360.925
43_Y110_F0.476040.924
24_A181_A0.474590.922
17_G185_I0.473480.919
250_R253_R0.473280.919
253_R256_F0.47310.919
164_L167_L0.471350.915
262_L265_F0.470920.915
358_L362_G0.470850.914
137_V390_R0.470730.914
148_A314_P0.469840.912
285_L288_Q0.469650.912
168_F171_L0.469010.911
38_L42_I0.468880.911
187_G190_L0.466950.907
258_Q384_N0.465410.904
328_W332_W0.465170.903
161_C165_A0.462140.897
257_R260_V0.460960.895
145_G149_R0.458770.891
331_W334_W0.45870.891
184_F187_G0.458640.891
82_V85_S0.458060.890
317_M376_A0.457180.888
42_I45_L0.456760.887
172_L176_A0.45620.886
332_W336_C0.456130.886
309_G313_Y0.456130.886
212_V215_R0.455850.885
395_G399_S0.455740.885
152_A310_T0.452550.879
173_M181_A0.449510.873
47_R113_L0.446050.866
193_V197_Y0.445780.866
156_R159_L0.445580.865
85_S119_I0.445190.865
157_I161_C0.444590.863
317_M321_G0.444440.863
151_N379_Q0.443990.862
163_L303_A0.442750.860
121_R125_I0.442370.859
39_P42_I0.442260.859
28_F32_I0.441110.857
199_L202_R0.44060.856
165_A169_V0.440290.855
209_A214_K0.440040.855
196_E199_L0.439580.854
214_K217_S0.438890.852
125_I129_I0.436370.847
365_L369_G0.43480.844
156_R307_L0.434160.843
180_I187_G0.433710.842
29_L32_I0.433430.842
275_L405_E0.432810.841
62_I391_G0.432120.839
339_L343_S0.432110.839
53_L57_W0.430890.837
390_R394_S0.430790.837
137_V151_N0.430340.836
329_S373_F0.43030.836
391_G395_G0.430250.836
180_I184_F0.430150.835
42_I110_F0.429430.834
52_I403_L0.428610.832
44_G279_G0.428120.831
403_L407_L0.427920.831
375_L379_Q0.423570.823
162_K303_A0.423390.822
104_W179_V0.421070.818
409_F412_T0.419880.815
156_R311_W0.419710.815
340_C343_S0.418960.814
53_L56_P0.417830.811
378_T382_Q0.417630.811
208_P212_V0.414530.805
76_V80_L0.414440.805
316_L319_R0.414360.805
39_P107_I0.413220.802
26_P30_I0.412620.801
399_S403_L0.410230.797
305_F308_L0.410010.796
290_Y298_F0.409550.795
47_R51_A0.408740.794
67_R129_I0.408660.794
246_R251_G0.405990.788
113_L116_L0.40580.788
396_V400_L0.40580.788
29_L35_G0.405640.788
152_A314_P0.405430.787
127_N154_M0.405060.787
25_V40_V0.404630.786
19_R22_E0.404260.785
263_A266_A0.40270.782
198_F201_A0.401950.781
335_V338_A0.401750.780
155_R159_L0.401580.780
330_L373_F0.401210.779
18_D51_A0.401180.779
355_S358_L0.40090.779
52_I402_S0.400840.778
364_A368_I0.400310.777
85_S109_L0.399720.776
181_A185_I0.399260.775
247_T251_G0.398860.775
296_G300_G0.397750.772
361_G364_A0.397330.772
273_T408_S0.396740.770
294_V298_F0.394730.767
166_P300_G0.394220.766
197_Y201_A0.39160.760
189_N192_S0.391420.760
202_R208_P0.39130.760
336_C340_C0.391060.759
258_Q386_P0.390860.759
152_A156_R0.390550.758
171_L293_S0.389680.757
275_L278_G0.389410.756
320_I328_W0.389370.756
265_F269_L0.388890.755
81_S84_A0.388560.755
24_A28_F0.388260.754
125_I128_T0.388240.754
51_A120_E0.388090.754
151_N154_M0.388050.754
29_L33_F0.38790.753
249_I252_W0.387490.753
251_G389_E0.387320.752
313_Y316_L0.387160.752
191_A195_V0.387080.752
160_F164_L0.386190.750
171_L174_T0.386090.750
247_T254_T0.383660.745
45_L48_S0.383540.745
213_K217_S0.383510.745
247_T250_R0.383460.745
55_G395_G0.38280.743
282_T286_K0.38230.742
175_F293_S0.382180.742
359_L362_G0.380880.740
79_N186_A0.380390.739
163_L304_V0.379880.738
26_P29_L0.379750.737
268_A272_F0.379560.737
30_I33_F0.379540.737
158_D162_K0.377620.733
105_L109_L0.377510.733
48_S409_F0.376860.732
306_G371_W0.376080.730
35_G40_V0.376030.730
58_V61_W0.375910.730
104_W112_L0.375520.729
316_L325_A0.375080.728
55_G402_S0.374770.728
146_A150_M0.374650.728
148_A379_Q0.374630.728
20_M181_A0.374350.727
17_G21_W0.374280.727
166_P299_R0.373740.726
117_G121_R0.37330.725
48_S405_E0.372640.724
300_G304_V0.372270.723
301_L305_F0.37010.719
149_R152_A0.369640.718
37_L287_S0.369450.717
170_G292_P0.369170.717
55_G399_S0.368340.715
188_W192_S0.368150.715
341_V345_W0.367450.714
49_L52_I0.366960.713
209_A215_R0.366610.712
82_V185_I0.365790.710
192_S196_E0.364960.709
322_L326_G0.363770.706
208_P213_K0.363730.706
343_S347_P0.362690.704
28_F40_V0.362550.704
309_G371_W0.361980.703
297_I300_G0.36160.702
31_S178_P0.361360.702
29_L37_L0.361060.701
375_L378_T0.360710.700
70_V74_S0.360670.700
45_L409_F0.360350.700
364_A367_R0.359630.698
355_S359_L0.359540.698
170_G297_I0.358740.697
332_W368_I0.358630.696
408_S411_L0.358380.696
129_I394_S0.357930.695
54_F58_V0.35690.693
407_L410_V0.3550.689
378_T397_Q0.354340.688
130_A139_I0.35380.687
83_A183_I0.352870.685
174_T291_S0.352860.685
31_S179_V0.352850.685
251_G256_F0.352710.685
71_I127_N0.35260.685
277_F281_M0.352260.684
64_R69_K0.351760.683
147_L382_Q0.351030.682
171_L297_I0.350220.680
147_L151_N0.349960.680
16_W20_M0.349780.679
45_L410_V0.349570.679
75_L193_V0.34950.679
336_C339_L0.348860.677
167_L297_I0.348810.677
326_G329_S0.348270.676
336_C362_G0.348170.676
85_S116_L0.348080.676
25_V29_L0.347880.676
118_A121_R0.347580.675
20_M169_V0.346970.674
20_M23_F0.34620.672
128_T154_M0.345510.671
148_A152_A0.344960.670
254_T388_S0.344660.669
155_R310_T0.343760.668
189_N193_V0.343150.666
113_L124_S0.343080.666
167_L170_G0.343080.666
257_R261_F0.342970.666
314_P317_M0.342730.666
252_W256_F0.342670.665
150_M157_I0.342390.665
48_S52_I0.342370.665
112_L115_L0.342130.664
144_P383_E0.342120.664
58_V121_R0.342080.664
337_L341_V0.341920.664
154_M157_I0.340420.661
274_V277_F0.340350.661
27_L173_M0.340080.660
329_S369_G0.33960.660
293_S296_G0.33890.658
279_G282_T0.33710.655
126_A129_I0.337050.655
75_L192_S0.336820.654
264_S267_L0.336490.653
280_L412_T0.336290.653
25_V44_G0.33580.652
155_R158_D0.335670.652
137_V382_Q0.335530.652
58_V62_I0.334730.650
178_P182_A0.334640.650
162_K166_P0.334480.650
373_F376_A0.33440.649
32_I35_G0.333440.648
381_M385_V0.333410.647
191_A194_F0.33330.647
33_F36_S0.333270.647
177_S181_A0.333130.647
76_V79_N0.333050.647
159_L162_K0.333030.647
410_V413_I0.330910.643
382_Q390_R0.330380.642
285_L359_L0.330030.641
358_L361_G0.329640.640
343_S362_G0.329050.639
114_I118_A0.329020.639
38_L41_S0.328260.637
363_I366_S0.327830.637
360_L363_I0.327790.637
50_S118_A0.327730.636
315_W320_I0.327650.636
43_Y46_V0.327570.636
271_Y373_F0.326760.635
194_F197_Y0.326140.633
409_F413_I0.326070.633
112_L119_I0.325930.633
56_P399_S0.325530.632
20_M185_I0.324980.631
80_L83_A0.324980.631
156_R310_T0.324630.630
17_G22_E0.324480.630
159_L307_L0.324480.630
42_I410_V0.324160.630
151_N155_R0.323990.629
373_F377_V0.323530.628
201_A208_P0.32340.628
74_S121_R0.323320.628
72_R201_A0.32330.628
16_W185_I0.323250.628
248_I253_R0.322740.627
303_A307_L0.322460.626
318_K321_G0.322110.626
301_L304_V0.321450.624
376_A379_Q0.321410.624
156_R160_F0.321110.624
285_L298_F0.320830.623
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4j05A0.92361000.232
1pw4A0.90051000.246
3o7qA0.85191000.274
2gfpA0.84031000.285
4apsA0.93291000.329
4gc0A0.94211000.358
4jr9A0.85651000.372
4iu9B0.85421000.373
2cfqA0.87041000.377
2xutA0.93981000.397

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