GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
ANKH - Progressive ankylosis protein (ANKH)
Pfam: PF07260 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 345
Sequences: 11179
Seq/Len: 32.4
HH_delta: 0.197 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
141_L202_A1.069383.691
157_H160_I1.023663.533
53_G280_T0.976223.369
110_G113_L0.957223.304
235_Q239_K0.947673.271
129_R133_L0.862732.978
312_L319_V0.826422.852
108_P113_L0.79642.749
130_R191_L0.788852.723
11_W15_R0.712222.458
301_P304_D0.601862.077
231_S235_Q0.597192.061
106_W133_L0.586222.023
37_G177_A0.584552.018
159_W163_S0.574021.981
230_D233_T0.568741.963
73_G90_M0.567291.958
105_A136_T0.562131.940
37_G180_L0.557641.925
38_L193_P0.556741.922
164_A207_I0.554031.912
51_S127_K0.551171.902
45_P48_T0.54751.890
138_L198_Y0.546791.887
85_K230_D0.53911.861
164_A208_V0.536371.851
110_G129_R0.535841.849
171_A203_V0.524311.810
77_V80_K0.524071.809
168_D204_R0.521681.801
189_P192_I0.518281.789
144_L205_F0.515361.779
325_S329_V0.501751.732
127_K130_R0.495971.712
126_E130_R0.49171.697
137_L140_F0.491631.697
134_Y194_I0.484071.671
305_K309_Q0.481151.661
94_G147_I0.476171.644
110_G116_D0.469331.620
322_S326_K0.463071.598
307_N312_L0.460691.590
75_V79_S0.457511.579
78_N305_K0.455981.574
191_L195_L0.452781.563
74_L77_V0.44851.548
77_V154_K0.448291.547
321_Q325_S0.442671.528
176_V193_P0.436181.505
82_S85_K0.435571.503
34_I197_L0.435261.502
242_W246_L0.432581.493
134_Y191_L0.431071.488
93_A234_L0.430781.487
258_V279_L0.424411.465
122_P126_E0.423451.462
301_P305_K0.421991.457
47_E123_S0.421011.453
307_N319_V0.41931.447
300_Y327_F0.41511.433
141_L205_F0.411251.419
148_H208_V0.40861.410
206_T210_L0.395861.366
180_L193_P0.395521.365
175_L196_A0.394651.362
76_F240_F0.39331.357
55_A132_F0.392871.356
18_I22_I0.391691.352
123_S126_E0.389641.345
109_L133_L0.388031.339
329_V333_L0.387991.339
87_V151_I0.38541.330
113_L116_D0.3851.329
35_N284_P0.384531.327
125_A129_R0.382551.320
302_A305_K0.380621.314
174_V177_A0.379731.311
174_V178_I0.376241.299
102_L140_F0.373231.288
116_D125_A0.371681.283
34_I172_Q0.37091.280
102_L106_W0.369911.277
109_L129_R0.366621.265
172_Q197_L0.365731.262
37_G176_V0.363041.253
116_D122_P0.36081.245
307_N310_N0.360361.244
36_A40_R0.359771.242
12_P15_R0.359291.240
163_S167_A0.358441.237
210_L214_Q0.358111.236
167_A170_I0.356891.232
260_L264_R0.356691.231
14_I18_I0.355071.226
26_A166_I0.353891.221
289_P292_W0.353121.219
137_L198_Y0.350541.210
103_L107_T0.349861.208
176_V196_A0.349771.207
134_Y195_L0.349651.207
319_V323_H0.348231.202
308_P320_T0.346581.196
86_A233_T0.346061.194
306_N310_N0.345671.193
36_A39_A0.345031.191
133_L137_L0.344581.189
263_S276_V0.343811.187
85_K89_C0.341191.178
262_V279_L0.33971.172
171_A175_L0.336151.160
134_Y198_Y0.334051.153
175_L179_L0.332031.146
172_Q176_V0.330561.141
302_A306_N0.327961.132
52_F190_L0.326611.127
177_A180_L0.326461.127
177_A181_S0.326061.125
78_N154_K0.324751.121
102_L105_A0.323421.116
113_L117_L0.321811.111
192_I196_A0.317481.096
151_I155_H0.314691.086
48_T127_K0.313891.083
21_A295_E0.313781.083
38_L52_F0.313351.082
300_Y304_D0.312461.078
59_M135_L0.311741.076
96_V100_I0.30941.068
170_I174_V0.308721.066
94_G143_A0.307661.062
152_L212_Y0.306961.059
134_Y137_L0.306711.059
35_N49_L0.30641.058
333_L337_A0.305381.054
115_N125_A0.304231.050
22_I162_G0.303621.048
85_K88_L0.302331.043
299_V304_D0.302241.043
249_A253_I0.30191.042
229_G234_L0.301881.042
24_S28_D0.301531.041
25_L29_L0.300841.038
177_A183_H0.300481.037
145_R204_R0.298331.030
157_H161_V0.297131.026
233_T236_R0.294951.018
92_V96_V0.294351.016
89_C234_L0.292211.009
50_A277_A0.289821.000
23_T165_S0.289470.999
102_L137_L0.289460.999
191_L194_I0.28930.999
122_P125_A0.288730.997
148_H205_F0.286160.988
178_I184_L0.284790.983
322_S325_S0.283970.980
84_R88_L0.283810.980
138_L201_I0.283530.979
171_A200_G0.283140.977
73_G77_V0.28230.974
305_K308_P0.28160.972
299_V302_A0.281590.972
232_A235_Q0.280990.970
160_I211_G0.280950.970
16_F19_P0.280190.967
109_L113_L0.280070.967
98_A136_T0.278920.963
320_T324_I0.27890.963
132_F136_T0.27880.962
329_V332_L0.278580.962
72_I75_V0.277040.956
16_F158_S0.277030.956
108_P114_I0.275350.950
37_G181_S0.27470.948
115_N128_T0.273150.943
149_Q153_I0.272090.939
54_L263_S0.271180.936
179_L199_A0.269540.930
164_A204_R0.269040.929
319_V322_S0.268690.927
195_L198_Y0.268630.927
334_L338_L0.268580.927
164_A168_D0.268530.927
153_I158_S0.26820.926
184_L189_P0.2670.922
39_A49_L0.264010.911
89_C229_G0.263440.909
207_I210_L0.263060.908
130_R133_L0.261460.902
92_V229_G0.260320.898
115_N129_R0.26020.898
322_S329_V0.26020.898
306_N309_Q0.260140.898
200_G204_R0.260050.898
332_L336_L0.259270.895
279_L283_Y0.259080.894
202_A206_T0.257840.890
103_L106_W0.257790.890
172_Q200_G0.257740.890
219_I222_Q0.257560.889
167_A207_I0.257050.887
196_A200_G0.256630.886
33_I173_V0.255650.882
203_V207_I0.254940.880
95_A144_L0.253380.875
299_V303_F0.252880.873
236_R239_K0.252630.872
73_G151_I0.251510.868
301_P306_N0.251390.868
48_T51_S0.251230.867
40_R181_S0.250830.866
100_I103_L0.250590.865
74_L78_N0.250070.863
51_S124_V0.249580.861
301_P308_P0.248920.859
176_V180_L0.248780.859
275_A278_V0.247990.856
156_R306_N0.247480.854
304_D320_T0.247320.854
157_H215_S0.246890.852
136_T139_P0.246830.852
175_L199_A0.246710.852
140_F143_A0.246530.851
303_F307_N0.245850.849
195_L199_A0.245550.848
295_E299_V0.2450.846
110_G126_E0.244940.845
168_D172_Q0.24490.845
238_L242_W0.244790.845
126_E129_R0.244010.842
217_H220_I0.2440.842
90_M237_M0.243990.842
66_L143_A0.241740.834
107_T113_L0.240040.829
164_A211_G0.239580.827
109_L132_F0.239410.826
245_A250_T0.238650.824
299_V305_K0.23820.822
47_E127_K0.237760.821
214_Q217_H0.236890.818
238_L241_W0.23540.812
161_V164_A0.235080.811
100_I104_I0.234620.810
304_D308_P0.234410.809
150_G153_I0.234150.808
304_D309_Q0.233460.806
99_V103_L0.233360.805
231_S234_L0.232720.803
29_L33_I0.232580.803
52_F56_Y0.232140.801
120_V263_S0.231390.799
83_R87_V0.230810.797
259_N263_S0.230750.796
153_I161_V0.230480.796
209_C213_Y0.229580.792
284_P287_H0.229550.792
210_L213_Y0.229440.792
152_L160_I0.228920.790
55_A135_L0.228890.790
166_I170_I0.228240.788
72_I240_F0.22780.786
68_M72_I0.227620.786
34_I176_V0.226190.781
46_V277_A0.225560.779
137_L141_L0.225390.778
74_L79_S0.225320.778
232_A236_R0.224560.775
50_A53_G0.224380.774
95_A99_V0.224290.774
302_A307_N0.223780.772
86_A90_M0.223480.771
12_P156_R0.223210.770
50_A124_V0.223070.770
179_L184_L0.222760.769
326_K330_L0.222480.768
146_W149_Q0.221860.766
299_V306_N0.221050.763
299_V309_Q0.220670.762
300_Y305_K0.219960.759
200_G203_V0.219420.757
17_F21_A0.218940.756
95_A140_F0.218690.755
233_T237_M0.218250.753
13_L17_F0.218130.753
145_R149_Q0.218050.753
287_H291_G0.217990.752
274_E277_A0.217420.750
68_M78_N0.217270.750
323_H326_K0.216740.748
303_F306_N0.216720.748
79_S308_P0.216420.747
266_L275_A0.215370.743
109_L136_T0.215370.743
198_Y202_A0.214270.740
152_L208_V0.21370.738
102_L136_T0.213570.737
239_K242_W0.213420.737
244_L247_V0.213250.736
123_S127_K0.212730.734
250_T254_S0.21220.732
258_V261_F0.211780.731
47_E50_A0.211680.731
256_P260_L0.211660.731
145_R205_F0.210210.726
89_C93_A0.210.725
148_H212_Y0.209850.724
23_T162_G0.20960.723
124_V127_K0.209320.722
257_L261_F0.209120.722
277_A281_A0.208070.718
240_F244_L0.207920.718
242_W245_A0.207830.717
13_L327_F0.207670.717
163_S166_I0.207190.715
106_W137_L0.207160.715
257_L260_L0.207030.715
305_K310_N0.206780.714
267_S275_A0.20650.713
252_R256_P0.20620.712
292_W295_E0.206090.711
54_L276_V0.205980.711
305_K311_K0.205850.710
145_R208_V0.205190.708
167_A171_A0.205170.708
68_M241_W0.204980.707
72_I241_W0.204960.707
254_S257_L0.204840.707
115_N132_F0.204690.706
52_F131_A0.204310.705
173_V177_A0.204110.704
74_L150_G0.204060.704
50_A276_V0.204040.704
14_I17_F0.203890.704
54_L120_V0.203770.703
75_V240_F0.203270.702
15_R18_I0.202820.700
53_G277_A0.202610.699
260_L263_S0.202530.699
70_H150_G0.201670.696
76_F86_A0.201010.694
303_F323_H0.200830.693
31_E56_Y0.200730.693
333_L336_L0.200540.692
161_V165_S0.200210.691
46_V274_E0.199720.689
136_T140_F0.19970.689
91_A94_G0.198960.687
98_A139_P0.198920.687
11_W14_I0.198680.686
32_Q36_A0.19840.685
198_Y201_I0.198040.684
300_Y306_N0.197730.682
49_L281_A0.197530.682
232_A239_K0.19740.681
20_L24_S0.197340.681
98_A143_A0.197110.680
309_Q312_L0.196790.679
107_T110_G0.196640.679
299_V310_N0.196510.678
57_S280_T0.195990.676
287_H290_Y0.195820.676
105_A109_L0.195750.676
279_L282_T0.195750.676
105_A132_F0.194740.672
88_L92_V0.194090.670
141_L198_Y0.193880.669
92_V95_A0.192920.666
38_L180_L0.192880.666
149_Q165_S0.192740.665
85_K228_K0.192170.663
193_P196_A0.191010.659
157_H211_G0.190540.658
20_L158_S0.189580.654
142_D201_I0.188950.652
168_D171_A0.188940.652
57_S259_N0.188410.650
251_Q255_R0.187390.647
69_F238_L0.187140.646
152_L161_V0.187020.646
85_K233_T0.1870.645
308_P312_L0.186960.645
110_G125_A0.186720.644
51_S190_L0.186250.643
76_F79_S0.186130.642
99_V140_F0.186120.642
58_L132_F0.186120.642
247_V251_Q0.186010.642
110_G133_L0.185910.642
76_F236_R0.185190.639
91_A148_H0.185050.639
54_L128_T0.184860.638
148_H209_C0.184820.638
196_A199_A0.184250.636
205_F209_C0.184180.636
52_F193_P0.183890.635
169_V173_V0.183380.633
176_V197_L0.182410.630
331_C335_S0.182130.629
167_A203_V0.182020.628
90_M147_I0.181970.628
307_N320_T0.181640.627
30_G33_I0.181530.627
326_K329_V0.181480.626
99_V102_L0.181190.625
165_S169_V0.181070.625
87_V90_M0.1810.625
48_T189_P0.180710.624
60_L64_S0.180030.621
330_L334_L0.180010.621
71_H244_L0.179180.618
56_Y60_L0.178550.616
95_A98_A0.178340.616
259_N276_V0.178270.615
130_R134_Y0.17790.614
194_I198_Y0.177890.614
33_I169_V0.177880.614
163_S210_L0.177810.614
89_C233_T0.177460.613
150_G154_K0.177320.612
294_T298_A0.176990.611
179_L192_I0.176470.609
274_E278_V0.17630.609
172_Q175_L0.176140.608
94_G98_A0.175520.606
30_G201_I0.175460.606
149_Q208_V0.175330.605
62_F139_P0.175310.605
329_V337_A0.175220.605
48_T190_L0.17480.603
294_T297_R0.174780.603
250_T253_I0.174650.603
64_S252_R0.174480.602
179_L193_P0.174350.602
56_Y59_M0.174220.601
16_F28_D0.173940.600
63_A67_S0.173750.600
175_L178_I0.173070.597
106_W136_T0.172950.597
34_I173_V0.172680.596
176_V192_I0.172530.595
160_I207_I0.172430.595
60_L252_R0.172160.594
214_Q218_D0.172030.594
53_G259_N0.171920.593
60_L63_A0.17190.593
35_N39_A0.171770.593
332_L335_S0.171260.591
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3w4tA0.94781000.197
3mktA0.95071000.211
4humA0.95651000.233
3w4tA0.643599.60.599
3mktA0.649399.60.6
4humA0.643599.40.637
3o7qA0.866772.90.909
1pw4A0.875446.70.922
4j05A0.904337.50.926
4apsA0.620316.30.938

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