GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF1464 - Protein of unknown function (DUF1464)
Pfam: PF07318 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0108
Length: 343
Sequences: 4727
Seq/Len: 13.78
HH_delta: 0.43 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
15_D19_K0.812543.552
23_Y303_K0.699253.057
107_I178_D0.67522.951
12_C306_A0.640342.799
203_I210_S0.628862.749
14_L310_A0.570382.493
158_L267_S0.569122.488
181_G260_D0.556492.432
241_E279_K0.549512.402
157_I254_L0.533352.331
211_K250_A0.49152.148
150_E156_F0.490122.142
153_E263_E0.481912.106
147_E311_I0.466582.039
155_N262_D0.462942.024
231_R235_D0.457361.999
201_Y210_S0.453561.983
244_I280_L0.453111.981
43_E99_E0.451951.976
230_K234_E0.450871.971
56_G313_A0.440821.927
172_K177_V0.439391.921
233_K275_E0.436911.910
245_E283_R0.424481.855
190_L253_S0.424231.854
189_Y203_I0.424171.854
255_L284_L0.42311.849
248_V283_R0.420161.837
201_Y204_G0.408731.787
251_V264_I0.402931.761
159_V251_V0.401441.755
92_K95_R0.401351.754
227_E231_R0.400971.753
94_V98_A0.399391.746
244_I279_K0.3941.722
281_E285_E0.38961.703
157_I170_A0.380441.663
6_T163_S0.379351.658
154_V173_N0.377071.648
166_T215_F0.374451.637
231_R238_C0.372511.628
274_P278_K0.370721.620
292_V295_L0.366631.603
244_I248_V0.363831.590
107_I312_I0.361551.580
110_V160_E0.360441.576
189_Y210_S0.352551.541
11_V45_F0.346351.514
278_K282_D0.344771.507
263_E296_E0.34391.503
7_K163_S0.343421.501
180_I262_D0.341181.491
161_I247_I0.340121.487
108_P186_F0.340041.486
282_D286_D0.338791.481
279_K282_D0.338511.480
249_K253_S0.326751.428
162_G269_R0.323911.416
191_S253_S0.321051.403
8_S217_G0.320241.400
66_E69_D0.316311.383
254_L257_S0.314281.374
255_L264_I0.308851.350
241_E283_R0.306671.340
277_R281_E0.306181.338
235_D238_C0.305121.334
227_E230_K0.304261.330
2_I11_V0.302951.324
12_C20_V0.29981.310
189_Y201_Y0.298181.303
65_R70_R0.297531.301
219_A243_M0.29561.292
283_R286_D0.295551.292
5_G163_S0.293411.283
156_F265_I0.290511.270
193_G196_D0.287251.256
204_G210_S0.286691.253
40_E99_E0.284151.242
39_V99_E0.284011.241
3_D7_K0.282221.234
241_E282_D0.280061.224
248_V287_Y0.279451.222
14_L20_V0.279241.221
7_K269_R0.278571.218
248_V284_L0.278111.216
187_P254_L0.277871.215
40_E44_E0.277791.214
248_V252_A0.277731.214
210_S213_D0.274051.198
157_I264_I0.272611.192
5_G269_R0.271661.187
105_Y313_A0.270121.181
283_R287_Y0.269261.177
153_E262_D0.268771.175
29_E41_E0.265871.162
57_Y100_S0.26391.154
66_E70_R0.262041.145
160_E305_A0.260761.140
192_H246_S0.260211.137
170_A258_V0.259141.133
37_I40_E0.255481.117
96_E99_E0.254861.114
146_R311_I0.254761.114
148_G151_Y0.253751.109
245_E249_K0.253141.107
36_S40_E0.250961.097
204_G209_F0.250681.096
193_G249_K0.24941.090
65_R69_D0.248311.085
26_I41_E0.246091.076
179_G184_I0.245431.073
156_F171_V0.245321.072
98_A104_A0.243711.065
41_E44_E0.242881.062
229_A240_W0.242811.061
199_V208_R0.241221.054
155_N172_K0.239961.049
97_L104_A0.239791.048
94_V106_F0.239351.046
154_V262_D0.238151.041
231_R234_E0.237491.038
164_G186_F0.236921.036
24_F47_D0.236721.035
251_V266_L0.232631.017
97_L100_S0.230361.007
6_T109_G0.229971.005
230_K233_K0.229941.005
24_F45_F0.229751.004
155_N177_V0.229511.003
153_E156_F0.228761.000
43_E100_S0.227540.995
249_K287_Y0.225370.985
95_R98_A0.225190.984
232_L240_W0.224450.981
67_I72_I0.222260.972
278_K281_E0.220660.965
92_K96_E0.220520.964
10_D25_S0.219540.960
150_E265_I0.21860.956
39_V96_E0.217780.952
212_N216_S0.215840.943
266_L271_S0.215010.940
3_D163_S0.214880.939
305_A309_A0.214750.939
274_P297_G0.213770.934
168_A187_P0.213310.932
170_A185_G0.213280.932
157_I168_A0.212440.929
35_P96_E0.212380.928
251_V284_L0.212040.927
220_I228_F0.212030.927
20_V23_Y0.211520.925
244_I276_F0.210890.922
247_I280_L0.209440.915
110_V169_I0.20870.912
279_K283_R0.208570.912
3_D6_T0.208360.911
198_E214_L0.208020.909
94_V104_A0.207610.907
147_E307_Q0.207510.907
203_I209_F0.205150.897
10_D217_G0.204310.893
8_S25_S0.203420.889
34_N37_I0.202780.886
201_Y209_F0.201330.880
14_L307_Q0.20060.877
148_G152_R0.200450.876
233_K274_P0.200030.874
11_V26_I0.199060.870
179_G260_D0.198920.870
191_S249_K0.198620.868
217_G270_F0.198550.868
219_A270_F0.198120.866
192_H211_K0.197580.864
24_F44_E0.196580.859
56_G103_P0.196480.859
15_D21_I0.196020.857
192_H250_A0.19590.856
269_R305_A0.195890.856
251_V280_L0.19560.855
277_R280_L0.195140.853
156_F263_E0.194810.852
4_P38_I0.19470.851
157_I251_V0.194320.849
2_I42_L0.19420.849
239_A242_A0.193020.844
9_F28_T0.192770.843
161_I271_S0.192310.841
163_S305_A0.192190.840
4_P42_L0.192020.839
109_G163_S0.191580.837
149_I265_I0.191240.836
66_E72_I0.191190.836
194_A197_G0.191050.835
5_G162_G0.190530.833
2_I9_F0.190530.833
11_V24_F0.190390.832
167_A186_F0.19030.832
109_G167_A0.189440.828
213_D221_K0.188980.826
40_E43_E0.187880.821
277_R297_G0.187040.818
170_A177_V0.186870.817
275_E278_K0.186440.815
158_L162_G0.186090.813
211_K215_F0.184790.808
212_N215_F0.184240.805
65_R68_T0.182440.797
311_I314_N0.182070.796
161_I217_G0.181960.795
244_I283_R0.180990.791
258_V261_P0.180050.787
189_Y204_G0.179450.784
3_D108_P0.178440.780
10_D269_R0.177990.778
209_F213_D0.177020.774
101_N104_A0.176820.773
154_V174_G0.176680.772
180_I260_D0.176590.772
163_S269_R0.175990.769
232_L275_E0.175280.766
105_Y312_I0.175060.765
241_E244_I0.1750.765
226_D230_K0.174280.762
191_S194_A0.174140.761
223_A239_A0.173870.760
172_K176_I0.172220.753
108_P164_G0.172050.752
59_L97_L0.171790.751
155_N180_I0.171310.749
150_E153_E0.170940.747
85_R202_L0.170540.745
222_I242_A0.170340.745
232_L244_I0.170120.744
60_P305_A0.16950.741
229_A233_K0.168860.738
3_D10_D0.168670.737
68_T71_E0.168320.736
243_M276_F0.168280.736
6_T160_E0.168270.736
67_I70_R0.167960.734
150_E261_P0.167940.734
41_E45_F0.16780.733
6_T269_R0.167750.733
3_D269_R0.167150.731
252_A256_A0.166870.729
190_L254_L0.166620.728
51_I54_P0.166550.728
16_D314_N0.16620.726
4_P9_F0.166070.726
242_A246_S0.164570.719
5_G217_G0.163970.717
161_I166_T0.163650.715
44_E47_D0.163510.715
273_I276_F0.162670.711
10_D303_K0.162630.711
282_D285_E0.162480.710
164_G167_A0.162410.710
54_P60_P0.162330.710
284_L295_L0.162330.710
232_L238_C0.16140.705
193_G214_L0.161190.705
109_G164_G0.161180.705
29_E33_K0.1610.704
211_K216_S0.159920.699
263_E294_K0.159850.699
62_K186_F0.159770.698
108_P167_A0.159480.697
222_I239_A0.159090.695
169_I176_I0.158680.694
6_T305_A0.158460.693
157_I261_P0.158320.692
293_R297_G0.157660.689
5_G8_S0.157510.688
109_G186_F0.157450.688
9_F26_I0.157320.688
10_D23_Y0.156950.686
14_L18_G0.156580.684
301_K304_E0.15640.684
159_V254_L0.156070.682
218_G222_I0.155710.681
6_T162_G0.15570.681
10_D306_A0.155440.679
171_V176_I0.155140.678
166_T211_K0.15510.678
303_K306_A0.154290.674
108_P160_E0.154130.674
255_L293_R0.154120.674
219_A239_A0.153920.673
149_I152_R0.15370.672
173_N177_V0.153540.671
212_N219_A0.153260.670
58_G312_I0.152890.668
245_E279_K0.152520.667
156_F262_D0.152130.665
160_E167_A0.152030.665
98_A101_N0.151480.662
193_G198_E0.151080.660
275_E279_K0.151070.660
164_G212_N0.1510.660
59_L62_K0.15090.660
48_I51_I0.15040.657
25_S303_K0.150190.656
3_D60_P0.149690.654
240_W244_I0.149630.654
159_V168_A0.149290.653
185_G260_D0.148880.651
292_V297_G0.148190.648
187_P190_L0.147980.647
26_I44_E0.14750.645
252_A287_Y0.147270.644
65_R72_I0.146660.641
209_F212_N0.146410.640
203_I213_D0.146380.640
179_G182_G0.146320.640
92_K106_F0.146210.639
190_L211_K0.145970.638
12_C23_Y0.14590.638
252_A284_L0.145750.637
7_K162_G0.145280.635
167_A182_G0.144310.631
70_R94_V0.144220.630
228_F240_W0.144180.630
209_F216_S0.143510.627
110_V167_A0.143320.626
5_G10_D0.142760.624
57_Y60_P0.142640.623
10_D302_A0.142590.623
28_T163_S0.142460.623
149_I299_A0.142350.622
109_G160_E0.14220.622
274_P277_R0.142080.621
68_T72_I0.141860.620
273_I277_R0.141690.619
228_F238_C0.141680.619
7_K217_G0.141090.617
189_Y212_N0.141020.616
60_P309_A0.140910.616
215_F246_S0.140630.615
250_A254_L0.140230.613
18_G146_R0.139940.612
3_D305_A0.139860.611
55_S58_G0.139680.611
159_V187_P0.139670.611
266_L277_R0.139640.610
84_G91_R0.139570.610
169_I172_K0.139360.609
60_P63_R0.139270.609
245_E286_D0.138770.607
36_S99_E0.137970.603
5_G268_G0.137830.602
190_L250_A0.137820.602
64_I84_G0.13770.602
24_F236_E0.13770.602
250_A257_S0.137060.599
208_R213_D0.136940.599
307_Q310_A0.136920.598
232_L279_K0.136690.597
146_R314_N0.136560.597
151_Y299_A0.136430.596
217_G269_R0.136420.596
244_I275_E0.13640.596
198_E213_D0.136310.596
164_G188_G0.136240.596
161_I276_F0.13620.595
261_P264_I0.136160.595
294_K297_G0.136160.595
267_S271_S0.13590.594
36_S96_E0.135410.592
267_S301_K0.135330.592
39_V43_E0.135280.591
3_D217_G0.133860.585
160_E163_S0.133790.585
179_G185_G0.133680.584
228_F235_D0.133240.582
189_Y209_F0.13320.582
308_G312_I0.133110.582
151_Y171_V0.13310.582
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3vglA0.81051000.43
3vovA0.80761000.436
4db3A0.7931000.437
4htlA0.7931000.443
2aa4A0.79011000.443
1z05A0.82511000.443
1z6rA0.8281000.444
3htvA0.81051000.444
2ap1A0.79591000.449
2qm1A0.80471000.454

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