GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF1524 - Protein of unknown function (DUF1524)
Pfam: PF07510 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0263
Length: 142
Sequences: 781
Seq/Len: 5.5
HH_delta: 0.899 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
128_T131_F0.525134.364
85_G132_I0.285692.374
56_H95_N0.273682.274
83_S136_Q0.248462.065
101_K105_E0.242162.013
88_T118_N0.230561.916
115_L118_N0.227031.887
28_L89_L0.220771.835
60_Q82_N0.202621.684
90_L98_I0.197691.643
116_I119_K0.187951.562
98_I110_Y0.181921.512
135_R139_L0.181651.510
120_E138_K0.177991.479
58_F77_R0.171561.426
90_L94_L0.165931.379
55_E106_K0.164891.370
83_S133_E0.162221.348
68_S72_W0.159991.330
82_N87_L0.159551.326
62_P66_S0.158551.318
80_Y83_S0.157221.307
126_E131_F0.156981.305
54_I87_L0.155991.296
134_E138_K0.151491.259
62_P100_N0.150171.248
88_T139_L0.150171.248
25_R28_L0.149521.243
54_I90_L0.146241.215
17_Y82_N0.145881.212
116_I122_A0.145771.211
25_R54_I0.139641.161
87_L96_S0.138991.155
82_N96_S0.138611.152
124_K131_F0.137331.141
88_T135_R0.136471.134
107_K125_D0.134771.120
85_G106_K0.133191.107
17_Y87_L0.132781.103
136_Q140_A0.132081.098
57_I110_Y0.13151.093
80_Y132_I0.131061.089
85_G128_T0.130771.087
137_E141_E0.130381.084
62_P77_R0.131.080
85_G136_Q0.129421.076
108_E112_K0.129211.074
88_T91_S0.129121.073
55_E85_G0.128921.071
55_E127_W0.128231.066
87_L95_N0.12631.050
117_L136_Q0.125041.039
58_F68_S0.124971.039
126_E141_E0.123941.030
42_N46_S0.123141.023
103_F107_K0.122621.019
59_P86_N0.121471.009
130_E134_E0.120371.000
127_W132_I0.119650.994
75_E79_I0.119640.994
62_P94_L0.118840.988
133_E137_E0.118370.984
58_F62_P0.118190.982
79_I84_I0.117160.974
73_D76_E0.116770.970
33_E82_N0.116510.968
56_H60_Q0.116110.965
32_L117_L0.114670.953
130_E141_E0.114570.952
58_F127_W0.11220.932
75_E133_E0.112140.932
129_E133_E0.111850.930
133_E141_E0.111610.928
24_L28_L0.110280.916
55_E128_T0.110260.916
74_E78_E0.10960.911
130_E133_E0.109370.909
90_L97_S0.108870.905
33_E37_R0.108230.899
126_E137_E0.108070.898
54_I60_Q0.108010.898
42_N48_L0.107560.894
45_S48_L0.107480.893
55_E95_N0.107470.893
29_A100_N0.107450.893
69_E72_W0.107420.893
114_N122_A0.106430.885
112_K141_E0.106210.883
72_W75_E0.106160.882
132_I136_Q0.105550.877
61_N100_N0.105460.876
101_K108_E0.105440.876
118_N121_L0.105150.874
65_E73_D0.104940.872
119_K130_E0.104590.869
47_N104_L0.103180.857
65_E133_E0.102910.855
57_I111_K0.102550.852
121_L124_K0.101690.845
108_E111_K0.101620.845
124_K134_E0.100730.837
118_N135_R0.10020.833
76_E129_E0.100150.832
56_H87_L0.100110.832
43_N81_L0.099920.830
91_S94_L0.099360.826
37_R114_N0.099150.824
113_S118_N0.098070.815
17_Y60_Q0.097520.810
57_I103_F0.097320.809
122_A131_F0.097210.808
77_R81_L0.097080.807
95_N99_S0.096920.805
49_E96_S0.096910.805
59_P139_L0.095880.797
32_L118_N0.095780.796
46_S137_E0.095070.790
78_E137_E0.094750.787
134_E137_E0.094180.783
29_A117_L0.093940.781
58_F94_L0.093870.780
125_D137_E0.093010.773
85_G127_W0.092980.773
107_K128_T0.092820.771
39_N97_S0.09240.768
34_N61_N0.091530.761
73_D90_L0.091380.759
44_F47_N0.09090.755
57_I88_T0.089340.742
60_Q96_S0.088970.739
25_R89_L0.088860.738
32_L47_N0.088830.738
80_Y133_E0.088740.737
54_I84_I0.088570.736
26_Y62_P0.088520.736
41_E45_S0.088430.735
58_F72_W0.08840.735
66_S100_N0.087720.729
86_N113_S0.087630.728
119_K122_A0.087140.724
43_N90_L0.087040.723
25_R85_G0.087020.723
94_L99_S0.086830.722
38_W41_E0.086810.721
89_L115_L0.086530.719
43_N130_E0.086340.718
89_L99_S0.086290.717
55_E98_I0.086240.717
88_T107_K0.086190.716
26_Y31_R0.085970.714
79_I133_E0.085670.712
106_K127_W0.085630.712
105_E109_E0.085510.711
34_N39_N0.085330.709
84_I94_L0.085260.709
57_I91_S0.084960.706
104_L134_E0.084910.706
28_L34_N0.084870.705
28_L132_I0.084610.703
58_F103_F0.084470.702
60_Q103_F0.084260.700
26_Y34_N0.084090.699
79_I83_S0.084080.699
20_N84_I0.083740.696
56_H100_N0.083730.696
104_L130_E0.083310.692
68_S71_D0.082760.688
65_E141_E0.082670.687
88_T117_L0.082240.683
59_P127_W0.082030.682
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2qgpA0.66938.60.899
2pu3A0.887313.80.918
2jb0B0.57047.40.927
1fr2B0.570470.927
7ceiB0.52116.50.929
3cl3A0.73942.80.939
3sbgA0.85211.40.948
3sp1A0.8381.40.948
1j8uA0.43661.30.949
2c9lY0.32391.30.949
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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