GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
7TMR-DISM_7TM - 7TM diverse intracellular signalling
Pfam: PF07695 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 205
Sequences: 1273
Seq/Len: 6.21
HH_delta: 0.925 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
85_R97_R0.356863.986
34_F194_E0.26923.007
8_F191_F0.233672.610
90_L97_R0.226112.525
23_Y32_L0.225672.520
171_L176_L0.212182.370
148_G152_A0.190822.131
40_S79_F0.177421.982
84_V155_F0.174781.952
19_S31_Y0.159121.777
154_Y204_Y0.15851.770
7_F10_G0.158131.766
33_Y86_S0.157591.760
6_G10_G0.15411.721
9_F49_S0.150891.685
145_W156_L0.149271.667
201_A204_Y0.147811.651
33_Y82_L0.147621.649
64_W68_L0.143431.602
15_L195_V0.140531.570
19_S199_S0.13831.545
36_L79_F0.138281.544
11_I192_L0.135021.508
141_I156_L0.134221.499
33_Y79_F0.13381.494
37_Y194_E0.133451.490
63_W67_H0.129081.442
53_F58_P0.128921.440
98_R101_L0.126961.418
90_L100_L0.1231.374
14_F195_V0.120421.345
190_G202_L0.119681.337
150_R204_Y0.119551.335
19_S34_F0.118821.327
171_L177_L0.117451.312
5_W188_P0.115321.288
190_G194_E0.11531.288
19_S35_A0.114331.277
158_G198_L0.114141.275
29_R86_S0.113791.271
31_Y55_F0.113561.268
16_A20_L0.111291.243
43_L72_F0.110881.238
52_L56_L0.109721.225
91_K97_R0.108951.217
34_F203_A0.108891.216
18_Y22_L0.10871.214
196_L200_L0.107661.202
16_A35_A0.107551.201
99_L102_I0.106181.186
41_V76_S0.105861.182
194_E198_L0.105671.180
49_S188_P0.104431.166
152_A190_G0.102921.149
139_I143_Y0.102131.141
16_A42_L0.1021.139
143_Y147_K0.10091.127
17_L27_R0.100881.127
199_S203_A0.100791.126
69_E156_L0.100391.121
94_P97_R0.100111.118
144_A149_N0.099631.113
31_Y34_F0.099511.111
7_F14_F0.097941.094
77_F80_F0.09681.081
16_A39_L0.096751.081
19_S23_Y0.096651.079
46_L164_L0.096631.079
68_L150_R0.095881.071
136_L140_I0.094841.059
81_L100_L0.09481.059
54_Q61_P0.094751.058
158_G197_L0.094181.052
16_A201_A0.093131.040
21_F141_I0.092881.037
44_Y73_L0.092821.037
162_F190_G0.09151.022
128_L143_Y0.091231.019
24_L92_R0.091151.018
138_L163_L0.091141.018
176_L196_L0.090871.015
6_G9_F0.090621.012
91_K142_I0.090361.009
155_F194_E0.090121.007
42_L45_F0.089641.001
144_A147_K0.089641.001
15_L202_L0.08961.001
41_V191_F0.089460.999
137_I155_F0.089210.996
97_R101_L0.08870.991
44_Y173_L0.088610.990
44_Y72_F0.088470.988
161_L197_L0.087970.982
143_Y146_R0.08770.979
7_F11_I0.087660.979
149_N152_A0.087520.977
31_Y202_L0.08730.975
83_F166_S0.086990.972
160_L164_L0.086830.970
9_F51_F0.086720.969
15_L21_F0.086680.968
56_L107_F0.086590.967
89_E92_R0.086570.967
20_L35_A0.086430.965
10_G15_L0.086190.963
154_Y200_L0.085680.957
200_L203_A0.085610.956
6_G50_G0.085170.951
10_G119_Y0.084870.948
102_I105_I0.084850.948
41_V45_F0.084820.947
18_Y26_R0.08480.947
33_Y37_Y0.084540.944
85_R101_L0.084450.943
87_F201_A0.08410.939
150_R153_R0.083750.935
115_P118_Y0.083560.933
42_L155_F0.083120.928
12_L37_Y0.082460.921
82_L128_L0.082030.916
79_F122_A0.081850.914
87_F155_F0.081830.914
108_A112_L0.081530.911
45_F48_L0.081470.910
24_L164_L0.081170.907
54_Q157_I0.081130.906
9_F47_I0.080950.904
29_R85_R0.080840.903
12_L42_L0.080750.902
94_P98_R0.08070.901
73_L141_I0.080520.899
29_R101_L0.080420.898
52_L70_Y0.080260.896
81_L165_S0.080180.895
44_Y169_D0.080060.894
31_Y87_F0.079770.891
13_L122_A0.07960.889
56_L104_L0.079540.888
44_Y48_L0.07940.887
162_F194_E0.07930.886
23_Y100_L0.079280.885
21_F203_A0.078840.881
158_G194_E0.07860.878
106_L193_L0.078480.877
193_L200_L0.078460.876
107_F114_L0.078380.875
85_R90_L0.078140.873
119_Y123_L0.078120.872
95_R108_A0.078110.872
39_L78_I0.077990.871
19_S194_E0.077930.870
61_P64_W0.077760.868
76_S152_A0.077660.867
65_S79_F0.077580.866
91_K94_P0.077510.866
145_W148_G0.077330.864
102_I106_L0.077240.863
106_L135_L0.077170.862
159_W170_I0.076870.859
88_L141_I0.076770.857
13_L163_L0.076610.856
24_L111_I0.076540.855
49_S52_L0.076390.853
138_L160_L0.076350.853
161_L167_L0.076190.851
15_L18_Y0.076160.851
105_I129_F0.076090.850
90_L193_L0.075950.848
11_I131_L0.075750.846
112_L115_P0.075740.846
67_H113_L0.075710.846
26_R38_C0.075680.845
10_G19_S0.075330.841
104_L160_L0.075190.840
5_W49_S0.075120.839
39_L157_I0.074960.837
30_S33_Y0.074960.837
77_F107_F0.074870.836
54_Q66_Q0.074810.836
48_L55_F0.074770.835
47_I69_E0.07460.833
126_F163_L0.074490.832
56_L180_N0.074460.832
194_E199_S0.074430.831
187_F192_L0.074350.830
142_I167_L0.074260.829
142_I147_K0.073940.826
74_M122_A0.07360.822
190_G203_A0.073580.822
125_L128_L0.073480.821
29_R91_K0.073470.821
145_W152_A0.073470.821
20_L135_L0.073350.819
162_F187_F0.07330.819
73_L196_L0.07320.818
44_Y127_S0.073190.817
39_L134_I0.073090.816
30_S202_L0.073090.816
31_Y41_V0.072980.815
8_F195_V0.07290.814
30_S155_F0.072890.814
151_P197_L0.072790.813
71_L75_L0.072690.812
160_L167_L0.072580.811
29_R180_N0.072530.810
158_G191_F0.072480.809
56_L65_S0.072360.808
164_L197_L0.072110.805
40_S163_L0.071970.804
85_R100_L0.071940.803
41_V114_L0.071880.803
37_Y155_F0.071870.803
137_I158_G0.071840.802
32_L100_L0.071660.800
39_L197_L0.071640.800
15_L190_G0.071610.800
170_I174_F0.071520.799
96_L167_L0.071260.796
80_F159_W0.071230.796
96_L108_A0.071030.793
105_I128_L0.070710.790
44_Y69_E0.070710.790
24_L35_A0.070470.787
15_L19_S0.070360.786
103_L120_D0.070040.782
76_S160_L0.069990.782
103_L145_W0.069970.781
121_S128_L0.069830.780
34_F37_Y0.069820.780
14_F203_A0.069730.779
4_I84_V0.069720.779
78_I158_G0.069690.778
104_L196_L0.069560.777
135_L146_R0.069530.777
22_L199_S0.06950.776
105_I109_L0.069340.774
15_L203_A0.069280.774
14_F58_P0.069230.773
139_I171_L0.069210.773
83_F88_L0.068890.769
150_R164_L0.068890.769
67_H115_P0.068880.769
77_F187_F0.068870.769
177_L180_N0.068820.769
15_L196_L0.06880.768
164_L167_L0.06840.764
101_L164_L0.068390.764
198_L202_L0.068260.762
34_F155_F0.068210.762
48_L51_F0.068120.761
82_L167_L0.068010.760
161_L193_L0.067970.759
121_S135_L0.067580.755
35_A155_F0.067570.755
33_Y161_L0.067560.755
14_F199_S0.067550.754
53_F118_Y0.067270.751
139_I164_L0.067190.750
13_L173_L0.067010.748
14_F21_F0.066970.748
21_F26_R0.066850.747
59_D98_R0.066830.746
112_L143_Y0.066660.744
111_I147_K0.066580.744
34_F90_L0.066310.741
27_R116_L0.066250.740
11_I196_L0.066180.739
82_L86_S0.066170.739
69_E72_F0.066160.739
78_I146_R0.066130.739
29_R43_L0.066110.738
58_P124_V0.066090.738
47_I124_V0.066070.738
6_G54_Q0.065870.736
82_L85_R0.065790.735
90_L94_P0.06570.734
189_I195_V0.065620.733
22_L152_A0.065440.731
12_L38_C0.065340.730
185_Y188_P0.065320.730
27_R145_W0.06530.729
72_F76_S0.065240.729
83_F148_G0.065230.729
11_I14_F0.065220.728
159_W163_L0.065080.727
145_W160_L0.065070.727
43_L157_I0.065060.727
26_R35_A0.065050.727
40_S75_L0.064990.726
11_I15_L0.064950.725
20_L27_R0.064910.725
92_R167_L0.064890.725
25_Q158_G0.064880.725
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2k1kA0.14154.90.925
2zxeA0.48784.50.926
2l6wA0.19024.30.927
3ixzA0.48783.80.929
4he8L0.60983.30.931
3bz1X0.16593.10.932
3ayfA0.29272.60.934
3arcX0.1612.60.934
2l34A0.13662.40.935
2k9yA0.14152.30.936
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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