GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Peptidase_C26 - Peptidase C26
Pfam: PF07722 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0014
Length: 217
Sequences: 3166
Seq/Len: 14.59
HH_delta: 0.192 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
119_L209_I0.726813.466
33_I38_G0.679743.241
188_V191_R0.585152.790
61_G108_P0.542062.585
153_R168_E0.523392.496
106_G206_K0.476482.272
189_T201_E0.473772.259
99_I109_I0.471452.248
101_N105_R0.449432.143
100_R104_G0.446262.128
111_G119_L0.427472.038
59_I62_L0.421162.008
109_I119_L0.419251.999
78_E180_K0.412851.969
158_S189_T0.407141.941
119_L211_G0.394431.881
151_P168_E0.378231.803
160_L199_A0.375761.792
92_D114_R0.374051.784
33_I63_L0.373731.782
43_I59_I0.361991.726
91_R95_E0.360351.718
62_L102_A0.356611.700
187_R203_P0.354971.693
99_I118_L0.354751.692
156_P161_A0.352151.679
155_V187_R0.342191.632
161_A167_E0.338421.614
64_L99_I0.338231.613
183_G186_L0.33811.612
31_K34_E0.334711.596
151_P170_E0.3311.578
128_Y180_K0.329131.569
109_I209_I0.323921.545
202_S209_I0.314421.499
49_D90_E0.308971.473
123_F186_L0.308151.469
149_S170_E0.304031.450
99_I122_A0.303951.449
159_L162_K0.302951.445
157_G161_A0.301751.439
120_N183_G0.301451.437
96_L122_A0.301071.436
101_N104_G0.300291.432
199_A214_W0.29931.427
64_L109_I0.297211.417
113_C215_H0.295891.411
116_M211_G0.29521.408
116_M179_V0.291841.392
33_I40_P0.291041.388
186_L200_I0.287131.369
155_V191_R0.278271.327
130_D176_H0.278031.326
120_N179_V0.27191.296
154_I190_A0.269841.287
102_A107_K0.261861.249
29_Y112_I0.260241.241
41_V58_R0.249361.189
159_L210_L0.249211.188
179_V200_I0.247181.179
156_P167_E0.246791.177
200_I211_G0.246291.174
178_A196_V0.244821.167
103_L123_F0.243551.161
160_L210_L0.242161.155
53_D101_N0.239271.141
63_L112_I0.238271.136
66_G215_H0.238151.136
154_I160_L0.236571.128
120_N125_G0.235351.122
34_E40_P0.230381.098
67_G95_E0.226591.080
160_L190_A0.224621.071
188_V197_I0.224621.071
60_D108_P0.224311.070
142_Q179_V0.223611.066
99_I209_I0.223551.066
29_Y65_P0.223451.065
55_L58_R0.220081.049
106_G204_E0.218821.043
62_L109_I0.218441.042
158_S201_E0.21651.032
116_M178_A0.216391.032
159_L201_E0.215431.027
116_M200_I0.215051.025
97_A101_N0.213291.017
32_A36_A0.212571.014
181_P184_E0.210571.004
48_D51_E0.210461.004
152_V214_W0.20910.997
150_H173_S0.208470.994
96_L100_R0.208260.993
123_F202_S0.206820.986
202_S205_H0.205120.978
182_L188_V0.205020.978
155_V158_S0.202610.966
152_V171_V0.202590.966
123_F183_G0.201340.960
153_R193_P0.201250.960
63_L110_L0.200530.956
99_I119_L0.200460.956
56_L107_K0.19970.952
131_I196_V0.196960.939
182_L200_I0.196790.938
120_N126_T0.193220.921
199_A212_V0.192330.917
89_P93_I0.19220.916
121_V127_L0.19160.914
52_L101_N0.190070.906
106_G205_H0.189550.904
100_R122_A0.188930.901
171_V216_P0.188750.900
150_H192_S0.185880.886
153_R191_R0.185190.883
54_E57_D0.182650.871
43_I58_R0.182390.870
121_V126_T0.181870.867
132_P139_D0.181840.867
28_S174_F0.181550.866
99_I123_F0.17990.858
37_G40_P0.179830.857
49_D52_L0.178350.850
179_V213_Q0.176460.841
57_D105_R0.176210.840
163_I210_L0.174330.831
187_R201_E0.173990.830
54_E58_R0.1730.825
126_T180_K0.172930.825
140_H145_Q0.172680.823
188_V200_I0.170580.813
30_V34_E0.170260.812
152_V190_A0.170030.811
161_A165_G0.167330.798
123_F127_L0.167050.797
41_V55_L0.166290.793
32_A112_I0.164190.783
154_I169_I0.163730.781
159_L163_I0.162450.775
110_L212_V0.162070.773
92_D96_L0.161470.770
67_G114_R0.161290.769
175_H215_H0.161290.769
30_V42_P0.161260.769
78_E129_Q0.160590.766
66_G175_H0.160110.763
33_I36_A0.159980.763
31_K35_A0.15990.762
153_R167_E0.159680.761
156_P164_L0.159580.761
64_L119_L0.158150.754
41_V59_I0.157850.753
120_N186_L0.157630.752
114_R174_F0.156930.748
173_S194_D0.156920.748
185_G203_P0.156010.744
118_L122_A0.155360.741
192_S196_V0.155170.740
150_H172_N0.154990.739
56_L59_I0.154670.737
136_G141_R0.152730.728
139_D181_P0.152580.728
190_A199_A0.150740.719
39_R55_L0.149930.715
192_S201_E0.149690.714
98_L101_N0.149610.713
33_I44_P0.148820.710
33_I37_G0.148720.709
145_Q148_P0.14850.708
79_E151_P0.148220.707
192_S198_E0.148160.706
149_S174_F0.147880.705
132_P143_H0.14740.703
171_V192_S0.146990.701
111_G117_Q0.146570.699
57_D93_I0.146530.699
109_I211_G0.146230.697
139_D142_Q0.145740.695
113_C175_H0.144640.690
41_V156_P0.144230.688
53_D105_R0.144210.688
66_G113_C0.143970.686
132_P142_Q0.143970.686
46_D59_I0.143910.686
66_G188_V0.143860.686
157_G187_R0.143150.683
213_Q217_E0.143120.682
93_I97_A0.14310.682
102_A109_I0.1430.682
120_N182_L0.142170.678
112_I212_V0.142010.677
152_V199_A0.141430.674
163_I208_P0.141050.673
89_P92_D0.140550.670
40_P114_R0.140440.670
157_G167_E0.140150.668
106_G208_P0.139450.665
157_G162_K0.139410.665
88_D92_D0.137970.658
59_I107_K0.137950.658
156_P184_E0.137220.654
135_P138_P0.137030.653
192_S195_G0.136640.652
67_G174_F0.136480.651
197_I200_I0.136330.650
39_R54_E0.13560.647
51_E54_E0.135120.644
128_Y196_V0.134910.643
114_R177_Q0.134890.643
66_G217_E0.134860.643
95_E103_L0.134520.641
44_P55_L0.13450.641
205_H208_P0.134450.641
97_A100_R0.134340.641
213_Q216_P0.134340.641
52_L97_A0.134020.639
67_G176_H0.133680.637
121_V137_F0.132970.634
33_I195_G0.132570.632
154_I167_E0.132540.632
186_L202_S0.132410.631
32_A66_G0.131770.628
60_D105_R0.131350.626
201_E210_L0.131340.626
65_P174_F0.131270.626
171_V190_A0.130790.624
29_Y63_L0.130760.623
182_L197_I0.130430.622
46_D51_E0.130320.621
114_R117_Q0.130280.621
86_Y89_P0.130060.620
120_N127_L0.129690.618
160_L189_T0.129650.618
53_D104_G0.129290.616
154_I164_L0.128510.613
32_A35_A0.128290.612
67_G118_L0.127890.610
68_G174_F0.127550.608
95_E118_L0.12730.607
56_L105_R0.126930.605
28_S33_I0.126680.604
30_V45_Y0.126580.604
132_P135_P0.126020.601
189_T210_L0.125980.601
152_V169_I0.124990.596
138_P141_R0.124280.593
121_V132_P0.124140.592
157_G184_E0.123940.591
164_L169_I0.123310.588
178_A213_Q0.123270.588
145_Q174_F0.123090.587
28_S65_P0.122690.585
159_L164_L0.12240.584
60_D106_G0.122280.583
119_L202_S0.122230.583
202_S208_P0.122030.582
158_S187_R0.121580.580
155_V182_L0.121450.579
87_I148_P0.120970.577
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3fijA0.98161000.192
1l9xA0.88021000.321
3nvaA0.85251000.415
1gpmA0.77881000.421
2vxoA0.82491000.428
2ywbA0.7651000.43
3tqiA0.77881000.435
2a9vA0.76961000.439
2vpiA0.76961000.442
1vcoA0.86181000.446

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