GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
WAK - Wall-associated kinase
Pfam: PF08488 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 103
Sequences: 587
Seq/Len: 5.7
HH_delta: 0.901 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
89_N92_E0.335523.351
4_C9_C0.299072.987
88_K91_T0.262762.624
50_F56_D0.173521.733
88_K92_E0.171281.711
33_N36_S0.162661.625
15_P39_C0.162451.622
49_W66_V0.160941.607
11_Q69_V0.149021.488
1_N40_K0.145641.455
7_I74_I0.139671.395
33_N37_N0.139391.392
46_D69_V0.135671.355
93_Y102_S0.134321.342
6_G9_C0.134261.341
16_S49_W0.133751.336
54_I57_P0.131821.317
17_G93_Y0.130371.302
41_V67_P0.130371.302
5_S12_T0.125511.254
12_T24_V0.122361.222
9_C15_P0.120881.207
7_I12_T0.120161.200
45_V49_W0.119791.196
42_A98_R0.118961.188
22_F47_E0.11811.180
72_W95_S0.117721.176
31_G81_F0.117481.173
11_Q72_W0.116111.160
38_G68_V0.115341.152
73_F86_A0.112121.120
46_D67_P0.112011.119
41_V92_E0.111991.118
24_V27_E0.111481.113
8_G87_C0.111441.113
5_S73_F0.111261.111
72_W98_R0.111111.110
68_V75_D0.111031.109
91_T96_S0.110281.101
11_Q67_P0.109881.097
39_C42_A0.109561.094
20_Q44_L0.108711.086
52_S57_P0.107691.076
34_Q37_N0.107441.073
14_I36_S0.107361.072
83_N96_S0.107311.072
57_P97_N0.107061.069
34_Q38_G0.106371.062
55_T81_F0.104411.043
7_I55_T0.104281.041
22_F61_H0.103581.034
11_Q98_R0.102911.028
41_V52_S0.102851.027
15_P69_V0.10131.012
57_P70_L0.100361.002
43_F50_F0.100181.001
47_E50_F0.100111.000
67_P71_D0.098720.986
93_Y100_S0.097940.978
79_S97_N0.097360.972
55_T58_E0.097110.970
22_F43_F0.095880.958
71_D75_D0.09550.954
79_S94_S0.093470.934
29_T42_A0.093270.932
35_T78_D0.093150.930
29_T88_K0.093090.930
8_G71_D0.092770.927
4_C10_C0.091940.918
25_T28_S0.091170.911
31_G54_I0.091050.909
12_T44_L0.09050.904
24_V98_R0.089230.891
14_I72_W0.089160.890
43_F70_L0.088910.888
82_S97_N0.088060.879
46_D50_F0.087520.874
55_T61_H0.08750.874
87_C91_T0.08750.874
5_S90_N0.086820.867
30_D34_Q0.086670.866
42_A50_F0.086640.865
46_D54_I0.086620.865
74_I85_L0.086430.863
48_D102_S0.086150.860
1_N55_T0.085870.858
80_S84_S0.085640.855
40_K52_S0.084640.845
12_T16_S0.084630.845
8_G38_G0.083640.835
28_S31_G0.083360.833
30_D56_D0.082980.829
61_H81_F0.082910.828
2_S14_I0.081910.818
43_F47_E0.080960.809
39_C71_D0.080310.802
40_K47_E0.08020.801
24_V71_D0.07980.797
55_T63_M0.079750.796
31_G65_Y0.07970.796
49_W69_V0.079670.796
75_D100_S0.079470.794
49_W78_D0.079330.792
79_S86_A0.07920.791
54_I97_N0.079020.789
21_V27_E0.078990.789
1_N54_I0.078940.788
42_A68_V0.078780.787
7_I21_V0.078420.783
20_Q70_L0.07830.782
51_S66_V0.078110.780
85_L94_S0.0780.779
25_T48_D0.077830.777
20_Q68_V0.07750.774
13_S94_S0.077140.770
87_C90_N0.076830.767
43_F64_G0.076740.766
1_N23_N0.076580.765
66_V69_V0.075860.758
58_E79_S0.075830.757
45_V76_T0.075810.757
26_I61_H0.075740.756
46_D100_S0.075570.755
60_F63_M0.075040.749
14_I20_Q0.075020.749
65_Y91_T0.074640.745
40_K66_V0.074540.744
59_D95_S0.074450.744
82_S90_N0.074090.740
12_T23_N0.073990.739
41_V50_F0.073810.737
90_N102_S0.073620.735
20_Q29_T0.073490.734
80_S97_N0.073160.731
35_T59_D0.073150.731
58_E90_N0.073150.731
24_V30_D0.073130.730
20_Q98_R0.073120.730
54_I62_A0.073120.730
85_L89_N0.07310.730
5_S14_I0.072890.728
39_C52_S0.072840.727
74_I83_N0.072510.724
62_A84_S0.07250.724
46_D51_S0.072480.724
17_G68_V0.072250.722
53_N57_P0.072210.721
44_L68_V0.071750.717
17_G52_S0.071710.716
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3fbyA0.436930.50.901
1k36A0.29132.30.94
1xn7A0.25242.30.94
2cqwA0.349520.942
2k2sB0.38831.90.943
1a3pA0.25241.50.945
1z6cA0.26211.40.947
2jq8A0.22331.30.947
1edmB0.29131.30.948
2hkyA0.64081.30.948
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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