GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
KR - KR domain
Pfam: PF08659 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0063
Length: 181
Sequences: 77728
Seq/Len: 429.44
HH_delta: -0.086 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
106_D114_R3.788842.788
106_D110_A3.569312.627
64_D67_A3.568542.626
3_Y84_G3.275072.410
154_A158_A3.166332.330
110_A114_R3.152842.320
69_A122_A3.005552.212
133_L160_A3.001442.209
38_S42_E2.678761.971
14_Q18_R2.67221.967
135_S157_D2.643611.946
19_W23_R2.616021.925
2_T27_R2.593651.909
31_L60_C2.44561.800
87_H133_L2.405861.771
8_G30_L2.379961.752
60_C67_A2.338991.721
56_E78_R2.239571.648
65_P102_P2.211.626
74_Q78_R2.200941.620
72_L123_L2.192621.614
27_R54_R2.136361.572
120_H163_R2.06091.517
3_Y20_L2.033791.497
14_Q44_A2.021161.487
162_Q166_R1.98221.459
25_A84_G1.969081.449
70_A74_Q1.963091.445
65_P118_N1.954851.439
14_Q47_E1.953951.438
65_P69_A1.948581.434
19_W22_E1.947051.433
42_E46_R1.941851.429
73_A77_Q1.923461.416
2_T81_P1.912671.408
116_L156_L1.902161.400
29_I75_L1.892891.393
85_V119_L1.892761.393
58_V74_Q1.88561.388
18_R47_E1.866381.374
67_A70_A1.858941.368
109_L113_V1.812651.334
74_Q77_Q1.812421.334
101_T104_E1.806261.329
69_A73_A1.803931.328
9_L32_G1.788171.316
2_T29_I1.783171.312
112_K152_A1.780641.310
3_Y25_A1.752851.290
113_V155_F1.736731.278
68_V119_L1.729241.273
86_I134_F1.717411.264
114_R118_N1.716771.263
31_L71_A1.701931.253
85_V123_L1.695561.248
60_C71_A1.678071.235
45_I49_E1.673791.232
102_P118_N1.668671.228
15_S18_R1.664651.225
93_A107_A1.653841.217
88_A134_F1.642991.209
27_R56_E1.639431.207
20_L25_A1.628031.198
34_S40_E1.609221.184
70_A73_A1.581521.164
46_R49_E1.542231.135
149_Y153_N1.53181.127
41_A57_Y1.525551.123
29_I56_E1.510841.112
66_E70_A1.509691.111
87_H120_H1.500061.104
5_I17_A1.483861.092
29_I58_V1.478971.088
93_A104_E1.473651.085
6_T87_H1.455751.071
18_R22_E1.450621.068
100_Q148_A1.443891.063
69_A125_N1.443711.062
104_E107_A1.439661.060
10_G14_Q1.42531.049
65_P121_E1.420731.046
4_L82_I1.414391.041
30_L55_V1.412681.040
109_L114_R1.39391.026
91_V111_P1.387251.021
38_S59_Q1.383091.018
15_S19_W1.378491.014
95_A104_E1.367231.006
91_V107_A1.35070.994
96_P99_D1.348930.993
63_T107_A1.340590.987
158_A161_R1.340470.987
117_W159_L1.339180.986
112_K153_N1.329990.979
27_R53_A1.324590.975
63_T110_A1.321950.973
42_E45_I1.320260.972
58_V78_R1.309570.964
43_A46_R1.300710.957
82_I123_L1.297840.955
103_D107_A1.297090.955
44_A47_E1.283880.945
120_H131_F1.277910.940
16_L86_I1.268260.933
122_A125_N1.262680.929
58_V71_A1.241710.914
10_G40_E1.241260.913
76_R126_R1.238280.911
62_V115_G1.233490.908
4_L31_L1.224490.901
17_A30_L1.224130.901
60_C68_V1.223830.901
66_E69_A1.223720.901
139_S157_D1.217360.896
116_L133_L1.217090.896
45_I57_Y1.200710.884
126_R129_D1.197560.881
150_A158_A1.174010.864
34_S39_A1.170640.862
87_H119_L1.161640.855
21_A53_A1.155510.850
4_L71_A1.154160.849
111_P115_G1.152990.849
43_A47_E1.135810.836
118_N122_A1.130940.832
109_L151_A1.129220.831
81_P126_R1.1280.830
12_L16_L1.126920.829
102_P114_R1.123370.827
85_V131_F1.121660.825
120_H159_L1.112960.819
157_D161_R1.106190.814
27_R31_L1.106140.814
40_E43_A1.096380.807
59_Q67_A1.096260.807
117_W121_E1.094580.806
39_A42_E1.092660.804
105_F114_R1.088470.801
62_V89_A1.08480.798
68_V118_N1.082890.797
105_F148_A1.082030.796
6_T119_L1.080960.796
49_E54_R1.077390.793
49_E52_G1.071420.789
16_L88_A1.070720.788
68_V122_A1.062520.782
20_L84_G1.058790.779
140_L157_D1.054470.776
84_G130_F1.042090.767
38_S41_A1.026570.755
39_A43_A1.022060.752
65_P122_A1.020710.751
161_R164_R1.018450.750
162_Q165_S1.01740.749
56_E74_Q1.017240.749
154_A157_D1.015810.748
21_A55_V1.015750.748
73_A76_R1.007090.741
2_T83_D1.006440.741
114_R117_W1.005580.740
107_A110_A1.005520.740
76_R81_P1.002430.738
72_L122_A1.001240.737
150_A154_A0.998430.735
116_L120_H0.995810.733
102_P121_E0.991720.730
102_P106_D0.984770.725
32_G57_Y0.980620.722
48_L53_A0.977610.719
44_A48_L0.977430.719
41_A45_I0.970490.714
117_W155_F0.9680.712
63_T111_P0.957270.704
154_A161_R0.931960.686
75_L78_R0.924450.680
138_S150_A0.922970.679
109_L152_A0.918250.676
9_L33_R0.917830.675
27_R30_L0.914370.673
87_H116_L0.912210.671
89_A115_G0.910920.670
113_V151_A0.910270.670
6_T89_A0.908440.669
156_L160_A0.905710.667
120_H133_L0.903150.665
38_S57_Y0.902660.664
13_G88_A0.889720.655
16_L19_W0.884920.651
16_L20_L0.883510.650
75_L80_G0.879670.647
143_G146_Q0.878360.646
116_L119_L0.875850.645
91_V108_V0.874960.644
133_L156_L0.865270.637
149_Y152_A0.864760.636
163_R166_R0.862440.635
151_A155_F0.860540.633
18_R21_A0.859590.633
136_S139_S0.858370.632
64_D68_V0.854410.629
34_S38_S0.853870.628
10_G34_S0.849440.625
120_H124_E0.84540.622
90_G112_K0.844530.622
54_R78_R0.838370.617
118_N121_E0.837850.617
72_L75_L0.834230.614
108_V148_A0.832310.613
109_L155_F0.832020.612
72_L76_R0.831150.612
67_A71_A0.830710.611
106_D118_N0.829380.610
107_A111_P0.828620.610
84_G132_I0.827110.609
65_P106_D0.81820.602
21_A54_R0.817960.602
153_N156_L0.8130.598
8_G17_A0.812210.598
76_R80_G0.810540.597
21_A48_L0.808960.595
142_G158_A0.803860.592
95_A99_D0.803540.591
45_I55_V0.798660.588
18_R48_L0.796060.586
105_F117_W0.795440.585
61_D64_D0.792660.583
2_T75_L0.79230.583
108_V152_A0.788380.580
48_L55_V0.782340.576
16_L134_F0.779440.574
148_A152_A0.776810.572
27_R32_G0.771470.568
131_F135_S0.770650.567
137_I141_L0.767960.565
72_L85_V0.765970.564
56_E59_Q0.762440.561
6_T88_A0.761710.561
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4ag3A0.9779100-0.086
4g81D0.9779100-0.084
4iuyA0.977999.9-0.073
3qp9A0.994599.9-0.07
3mjeA0.994599.9-0.06
3slkA0.983499.9-0.056
4impA0.972499.9-0.049
3gedA0.955899.9-0.048
4fgsA0.961399.9-0.047
3tfoA0.977999.9-0.045

Page generated in 0.0268 seconds.