GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
C8 - C8 domain
Pfam: PF08742 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 74
Sequences: 1048
Seq/Len: 14.16
HH_delta: 0.906 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
39_C45_C0.921794.727
56_E59_R0.443372.273
25_P53_Y0.403542.069
19_C57_C0.401072.057
20_H53_Y0.386271.981
16_F20_H0.29921.534
8_C11_L0.297171.524
32_C37_C0.296951.523
16_F19_C0.281951.446
10_I50_L0.281561.444
20_H25_P0.2771.420
26_D30_E0.274071.405
8_C16_F0.266631.367
46_L72_L0.266551.367
51_S68_R0.263261.350
12_L29_Y0.261481.341
47_C73_C0.260131.334
29_Y33_V0.257041.318
48_E58_Q0.251591.290
36_M46_L0.232511.192
50_L72_L0.227711.168
21_S62_I0.227121.165
56_E60_A0.225441.156
50_L64_V0.209221.073
31_A70_P0.205091.052
54_A64_V0.204621.049
51_S55_R0.202381.038
8_C19_C0.201931.035
30_E55_R0.20051.028
68_R72_L0.199171.021
40_P44_Q0.197121.011
52_A55_R0.192640.988
24_D27_P0.190710.978
23_V53_Y0.190370.976
53_Y62_I0.188850.968
22_V62_I0.186750.958
36_M42_S0.186210.955
69_T72_L0.185880.953
46_L50_L0.185840.953
16_F54_A0.185790.953
46_L52_A0.18440.946
55_R58_Q0.178430.915
24_D31_A0.177510.910
43_Q69_T0.175320.899
47_C68_R0.175050.898
5_E9_G0.173440.889
4_A29_Y0.173330.889
7_Y71_T0.171150.878
32_C35_D0.170310.873
12_L27_P0.169760.870
10_I36_M0.167720.860
10_I13_D0.167280.858
36_M51_S0.16540.848
14_P17_A0.164010.841
23_V56_E0.163620.839
5_E65_G0.163160.837
5_E14_P0.160490.823
14_P65_G0.159860.820
58_Q64_V0.159480.818
49_A58_Q0.158560.813
26_D44_Q0.158020.810
20_H37_C0.157920.810
26_D70_P0.157390.807
21_S30_E0.157280.806
10_I27_P0.15710.806
7_Y12_L0.154760.794
32_C47_C0.153970.790
45_C51_S0.151050.775
11_L29_Y0.150510.772
13_D17_A0.150330.771
41_G60_A0.149360.766
13_D42_S0.148260.760
18_P64_V0.147510.756
11_L16_F0.147190.755
40_P70_P0.146850.753
24_D55_R0.146110.749
47_C61_G0.145290.745
12_L25_P0.144510.741
4_A28_F0.143890.738
20_H50_L0.143050.734
38_A48_E0.142640.731
36_M48_E0.142050.728
27_P59_R0.141670.726
14_P30_E0.141250.724
40_P43_Q0.140490.720
6_S13_D0.140430.720
35_D61_G0.139630.716
67_W73_C0.137690.706
16_F53_Y0.137530.705
29_Y65_G0.136540.700
55_R59_R0.136290.699
15_E65_G0.136030.698
17_A61_G0.135770.696
15_E56_E0.134990.692
6_S10_I0.134870.692
33_V41_G0.13450.690
53_Y64_V0.134410.689
15_E63_C0.13410.688
6_S21_S0.133350.684
22_V55_R0.133120.683
25_P34_Y0.132890.681
42_S45_C0.132410.679
47_C67_W0.132160.678
35_D49_A0.13210.677
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3ru6A0.48652.90.906
3eq5A0.36491.70.916
4hsaC0.91891.30.921
3ghmA0.94591.30.921
4bq6C0.83781.30.922
3e07A0.48651.10.925
3pm2A0.75680.90.927
2vlaA0.94590.90.929
4g7xA0.54050.80.931
3etpA0.45950.80.932
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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