GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
RES - RES domain
Pfam: PF08808 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 170
Sequences: 775
Seq/Len: 4.56
HH_delta: 0.937 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
35_P119_E0.251522.538
49_T141_G0.251422.537
30_G34_N0.239852.420
24_P27_A0.227782.298
35_P115_Q0.201262.031
86_L128_F0.193671.954
26_A30_G0.180451.821
133_Y145_A0.178641.802
130_G146_L0.171751.733
31_G34_N0.168021.695
133_Y143_N0.163941.654
45_S144_L0.162231.637
131_I145_A0.160431.619
74_L88_L0.158411.598
35_P38_F0.157881.593
45_S132_L0.155791.572
44_A49_T0.15511.565
86_L121_I0.14841.497
27_A30_G0.141811.431
114_T117_W0.139921.412
26_A34_N0.13941.407
44_A50_A0.134751.360
111_Y115_Q0.132581.338
114_T121_I0.132261.334
43_A146_L0.13211.333
60_F63_L0.130951.321
33_F137_R0.130171.313
40_V145_A0.129971.311
49_T138_S0.12541.265
132_L144_L0.123381.245
45_S49_T0.121631.227
56_V137_R0.121121.222
49_T135_S0.118391.195
46_S49_T0.117011.181
138_S141_G0.115381.164
46_S142_R0.115221.163
61_A65_P0.114761.158
86_L120_A0.109631.106
88_L126_P0.109431.104
61_A67_R0.108911.099
132_L142_R0.108811.098
42_Y53_E0.107161.081
57_H137_R0.10671.077
133_Y147_F0.106541.075
113_I122_R0.105761.067
73_R102_P0.104611.055
117_W122_R0.103141.041
34_N40_V0.10291.038
77_L130_G0.102431.033
36_P39_G0.10231.032
44_A58_R0.100341.012
34_N136_A0.099171.001
75_P148_D0.098750.996
29_G142_R0.098520.994
115_Q121_I0.098390.993
40_V58_R0.095750.966
51_L141_G0.095320.962
97_L100_L0.094940.958
38_F119_E0.094660.955
25_G75_P0.094210.951
76_D134_P0.094050.949
54_V104_I0.094010.949
116_A120_A0.093680.945
60_F68_V0.093080.939
97_L138_S0.093080.939
67_R70_E0.092360.932
31_G52_A0.092030.929
111_Y147_F0.091370.922
137_R149_P0.091230.920
52_A141_G0.091130.919
41_L146_L0.09080.916
34_N57_H0.090730.915
36_P84_S0.090590.914
37_G55_R0.089990.908
48_E138_S0.089650.905
101_D145_A0.089280.901
105_S134_P0.089190.900
31_G145_A0.088860.897
58_R62_T0.088410.892
118_A136_A0.088190.890
73_R142_R0.087710.885
117_W133_Y0.087560.883
82_S142_R0.087520.883
114_T140_G0.087430.882
103_D107_P0.087340.881
113_I116_A0.087140.879
130_G144_L0.086920.877
44_A143_N0.086460.872
133_Y150_H0.085930.867
48_E88_L0.085770.865
29_G48_E0.085720.865
38_F115_Q0.085670.864
111_Y130_G0.084310.851
76_D119_E0.084270.850
30_G52_A0.084180.849
72_T82_S0.084110.849
26_A31_G0.083090.838
78_R84_S0.082270.830
127_G141_G0.082250.830
50_A100_L0.082210.829
119_E144_L0.082070.828
107_P127_G0.081870.826
43_A148_D0.081460.822
81_R129_D0.081460.822
69_L74_L0.081150.819
73_R132_L0.081060.818
107_P113_I0.080420.811
85_V113_I0.080210.809
104_I107_P0.080160.809
82_S100_L0.079860.806
47_P73_R0.079640.804
54_V61_A0.079380.801
55_R137_R0.079270.800
53_E143_N0.079230.799
111_Y122_R0.079120.798
64_V68_V0.079040.797
58_R128_F0.078820.795
100_L131_I0.078470.792
115_Q136_A0.078270.790
100_L111_Y0.07780.785
119_E131_I0.07770.784
40_V118_A0.077630.783
114_T118_A0.077530.782
99_W150_H0.077060.778
24_P28_S0.076880.776
33_F56_V0.076580.773
98_G114_T0.076260.769
46_S139_P0.076180.769
85_V119_E0.076090.768
104_I117_W0.076050.767
84_S127_G0.075930.766
46_S98_G0.075480.762
121_I136_A0.075260.759
98_G112_R0.07520.759
54_V142_R0.074930.756
87_D140_G0.074720.754
68_V73_R0.07460.753
44_A133_Y0.074510.752
118_A148_D0.074270.749
116_A121_I0.074170.748
58_R74_L0.074030.747
61_A64_V0.0740.747
44_A82_S0.07360.743
46_S117_W0.073040.737
121_I126_P0.07290.736
27_A58_R0.072750.734
81_R87_D0.072290.729
100_L146_L0.072230.729
111_Y133_Y0.072010.727
56_V143_N0.071960.726
77_L133_Y0.071730.724
97_L129_D0.07170.723
136_A143_N0.071280.719
36_P48_E0.0710.716
103_D113_I0.070940.716
47_P134_P0.070930.716
65_P140_G0.070870.715
136_A147_F0.070790.714
116_A133_Y0.070750.714
28_S113_I0.070670.713
29_G65_P0.070590.712
41_L51_L0.070540.712
117_W131_I0.070530.712
136_A139_P0.070370.710
143_N149_P0.070340.710
60_F128_F0.070210.708
143_N148_D0.07020.708
47_P69_L0.069850.705
118_A137_R0.069830.705
78_R81_R0.069760.704
29_G45_S0.069640.703
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
4ab7A0.376560.937
2equA0.35885.20.939
3ztpA0.347150.939
3s6gA0.31764.90.939
3s6kA0.33533.30.944
2ldmA0.34123.10.944
4aneA0.31763.10.944
1xqiA0.32942.90.945
1g5vA0.37652.80.946
1t01B0.15292.70.946
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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