GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
BAAT_C - BAAT Acyl-CoA thioester hydrolase C terminal
Pfam: PF08840 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0028
Length: 213
Sequences: 11716
Seq/Len: 55
HH_delta: 0.134 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
25_G48_A2.0075.186
40_A49_V1.276793.299
124_E157_P1.208583.123
154_L202_K1.175373.037
26_I36_A1.140992.948
119_L206_F1.139232.943
53_S126_D1.041022.690
25_G207_L0.996482.575
23_K47_S0.924762.389
33_A54_P0.917722.371
12_W16_H0.853342.205
37_L51_A0.814052.103
124_E155_S0.808732.090
156_Y202_K0.770511.991
51_A54_P0.76611.979
50_V203_I0.760971.966
11_D45_Q0.760091.964
152_E209_K0.736251.902
195_A198_D0.735171.899
202_K205_E0.729041.884
36_A49_V0.721651.865
118_I142_L0.698741.805
49_V118_I0.694661.795
30_S161_H0.682981.765
122_S153_H0.670881.733
39_L43_F0.659641.704
27_I52_I0.642851.661
136_E155_S0.636291.644
10_I46_I0.624421.613
25_G50_V0.598671.547
122_S155_S0.597521.544
11_D15_S0.59381.534
152_E202_K0.584161.509
5_Y8_E0.582951.506
25_G47_S0.574541.484
50_V119_L0.57041.474
119_L152_E0.567831.467
7_E11_D0.565881.462
139_E153_H0.556821.439
50_V207_L0.55611.437
52_I203_I0.551381.425
48_A206_F0.55061.423
201_K205_E0.547781.415
27_I50_V0.544221.406
36_A40_A0.543231.404
156_Y159_A0.541411.399
137_Q141_R0.53351.378
52_I199_S0.524171.354
38_L42_R0.523731.353
122_S131_S0.518981.341
204_L208_R0.513351.326
198_D202_K0.510341.319
14_K45_Q0.494221.277
125_D158_G0.492551.273
131_S155_S0.49131.269
28_G36_A0.487621.260
48_A117_P0.486951.258
119_L154_L0.485811.255
139_E143_K0.482861.248
29_I162_L0.472371.220
29_I53_S0.470741.216
28_G32_G0.470521.216
20_D23_K0.469951.214
121_I199_S0.468411.210
12_W15_S0.452041.168
136_E140_E0.451191.166
159_A163_I0.445851.152
159_A195_A0.444671.149
24_I46_I0.427941.106
4_E42_R0.425581.100
87_P90_L0.416771.077
29_I52_I0.414581.071
51_A120_L0.411961.064
200_W204_L0.404091.044
7_E42_R0.402841.041
110_P113_K0.394761.020
30_S162_L0.390281.008
26_I39_L0.389521.006
107_A110_P0.378740.979
6_F39_L0.375940.971
163_I166_P0.373180.964
122_S135_A0.371230.959
10_I14_K0.370550.957
31_K34_E0.368440.952
198_D201_K0.364460.942
11_D43_F0.364310.941
136_E153_H0.35850.926
33_A53_S0.358080.925
74_Y77_F0.353160.912
205_E208_R0.352730.911
205_E209_K0.350160.905
124_E158_G0.348920.902
97_E101_D0.347390.898
53_S123_G0.344680.891
120_L138_I0.342530.885
121_I156_Y0.341410.882
8_E11_D0.340660.880
55_S129_W0.340610.880
28_G33_A0.337020.871
200_W203_I0.333960.863
140_E143_K0.332870.860
93_R97_E0.33140.856
50_V121_I0.328590.849
55_S58_V0.327160.845
76_P80_S0.325150.840
137_Q140_E0.323560.836
39_L46_I0.320070.827
48_A207_L0.319310.825
7_E39_L0.318690.823
46_I49_V0.317160.819
30_S53_S0.316320.817
27_I207_L0.31460.813
28_G40_A0.311920.806
15_S45_Q0.310670.803
121_I154_L0.307940.796
78_D82_F0.307930.796
56_S138_I0.30780.795
126_D129_W0.307230.794
10_I39_L0.307030.793
27_I203_I0.306640.792
135_A139_E0.299740.774
48_A119_L0.299380.774
162_L165_P0.299130.773
7_E43_F0.297220.768
156_Y198_D0.295510.764
120_L139_E0.293610.759
197_E201_K0.291880.754
152_E155_S0.291770.754
31_K35_L0.28920.747
136_E139_E0.288630.746
5_Y9_A0.288320.745
14_K24_I0.28810.744
152_E206_F0.287630.743
95_A98_L0.287520.743
34_E38_L0.286320.740
112_E141_R0.286230.740
26_I46_I0.285480.738
130_P133_E0.285160.737
102_K106_E0.283110.731
14_K17_P0.2830.731
159_A166_P0.282810.731
37_L138_I0.282290.729
30_S165_P0.28210.729
121_I202_K0.27950.722
91_R94_Y0.278750.720
119_L202_K0.277930.718
8_E42_R0.277230.716
196_Q199_S0.276830.715
132_S136_E0.276250.714
37_L56_S0.276180.714
140_E144_A0.275550.712
160_G163_I0.272970.705
166_P195_A0.272750.705
34_E55_S0.272680.705
106_E109_I0.272150.703
28_G49_V0.2720.703
131_S136_E0.271530.702
109_I113_K0.270430.699
74_Y78_D0.269510.696
163_I199_S0.269490.696
122_S129_W0.268820.695
154_L198_D0.268360.693
166_P196_Q0.266130.688
85_N89_L0.265750.687
94_Y97_E0.263410.681
38_L41_S0.263190.680
40_A116_G0.263140.680
123_G157_P0.262550.678
77_F80_S0.262050.677
33_A51_A0.261750.676
53_S162_L0.260470.673
102_K105_E0.259060.669
144_A209_K0.258680.668
89_L93_R0.2580.667
141_R144_A0.257810.666
100_D103_A0.25780.666
120_L153_H0.255290.660
138_I142_L0.254040.656
93_R98_L0.252730.653
32_G35_L0.252580.653
160_G166_P0.252340.652
49_V116_G0.251610.650
100_D104_V0.251450.650
78_D83_S0.251350.649
124_E131_S0.25070.648
120_L135_A0.250460.647
71_P77_F0.249860.646
59_F67_D0.249460.645
48_A51_A0.248470.642
92_S96_F0.248190.641
14_K39_L0.247120.638
106_E110_P0.247110.638
29_I164_E0.246860.638
89_L97_E0.246720.637
7_E14_K0.246380.637
61_G65_Y0.245540.634
52_I164_E0.244040.631
88_G95_A0.242960.628
30_S33_A0.242580.627
43_F46_I0.242290.626
111_V114_I0.241560.624
199_S203_I0.240630.622
13_L19_V0.237540.614
18_E46_I0.2370.612
159_A196_Q0.236430.611
41_S114_I0.235160.608
8_E12_W0.235140.608
62_I67_D0.234940.607
23_K45_Q0.234210.605
123_G163_I0.234060.605
159_A198_D0.233530.603
7_E46_I0.233350.603
72_L79_I0.232890.602
47_S50_V0.232310.600
156_Y163_I0.232040.600
196_Q200_W0.230820.596
123_G126_D0.23010.595
81_K87_P0.229220.592
53_S122_S0.228870.591
10_I24_I0.228190.590
72_L76_P0.227870.589
52_I121_I0.227250.587
80_S84_W0.226720.586
28_G31_K0.226450.585
93_R96_F0.226030.584
90_L96_F0.225520.583
142_L145_A0.225460.583
6_F35_L0.22450.580
88_G92_S0.223710.578
203_I207_L0.223540.578
98_L101_D0.223370.577
164_E199_S0.223320.577
89_L100_D0.222650.575
93_R99_A0.220960.571
139_E145_A0.220160.569
164_E200_W0.220020.568
29_I128_I0.219810.568
86_E89_L0.219390.567
82_F85_N0.219380.567
62_I140_E0.21860.565
28_G51_A0.217730.563
7_E10_I0.217150.561
26_I49_V0.217150.561
5_Y12_W0.216640.560
40_A46_I0.216580.560
123_G159_A0.215640.557
86_E92_S0.214210.553
98_L104_V0.214050.553
6_F9_A0.213850.553
7_E12_W0.213840.553
109_I112_E0.213270.551
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3k2iA0.985999.90.134
3hlkA0.985999.90.142
1z68A0.755999.70.289
2ecfA0.751299.70.289
2z3zA0.741899.70.292
4hxfB0.798199.70.295
4a5sA0.765399.70.297
3o4hA0.765399.70.3
3azoA0.793499.70.307
1xfdA0.755999.70.309

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