GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF2236 - Uncharacterized protein conserved in bacteria (DUF2236)
Pfam: PF09995 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 242
Sequences: 1158
Seq/Len: 4.79
HH_delta: 0.949 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
148_T151_E0.403414.583
120_T123_E0.287043.261
208_P212_D0.246782.803
113_E124_R0.235842.679
42_D45_R0.20412.319
154_E158_D0.17632.003
126_A130_E0.175941.999
133_Y137_L0.174071.977
45_R49_R0.16251.846
219_T222_W0.158491.800
125_E150_A0.143631.632
24_Y33_L0.141191.604
18_R106_Y0.137841.566
102_A152_F0.137291.560
124_R149_Y0.135221.536
54_V104_F0.133441.516
32_A89_I0.132691.507
81_G89_I0.132461.505
66_R70_A0.132191.502
53_F72_V0.13041.481
133_Y136_H0.129771.474
25_A210_V0.128421.459
169_P173_E0.125981.431
101_L135_G0.124581.415
36_T89_I0.122871.396
150_A154_E0.122461.391
70_A73_R0.120251.366
16_G29_I0.120071.364
135_G145_L0.119931.362
109_L124_R0.119021.352
212_D224_R0.118591.347
38_R41_D0.118521.346
17_G198_L0.117821.338
129_H132_R0.117421.334
74_R77_A0.117231.332
147_A151_E0.116891.328
140_V145_L0.116441.323
211_R218_W0.115271.309
153_R157_D0.11521.309
203_R212_D0.114711.303
53_F69_I0.114621.302
121_D124_R0.114451.300
53_F138_L0.114281.298
56_E68_A0.114281.298
29_I103_T0.114231.298
160_L209_R0.112391.277
20_L24_Y0.111611.268
31_A170_E0.111591.268
30_A171_A0.111541.267
204_A218_W0.111281.264
40_R173_E0.111181.263
37_G59_F0.110811.259
205_L210_V0.110511.255
20_L23_Q0.110381.254
36_T79_V0.108241.230
121_D125_E0.108071.228
221_W225_L0.106831.214
151_E154_E0.105691.201
122_A126_A0.104821.191
123_E126_A0.103451.175
80_R126_A0.102821.168
83_L87_V0.102351.163
53_F68_A0.102191.161
57_V72_V0.101571.154
24_Y29_I0.100961.147
119_L124_R0.100821.145
18_R21_L0.100781.145
136_H147_A0.100771.145
73_R139_G0.099461.130
102_A156_L0.098611.120
218_W223_R0.09831.117
21_L175_A0.097751.110
29_I210_V0.097751.110
23_Q100_T0.097611.109
20_L104_F0.097381.106
109_L125_E0.096851.100
193_P196_P0.096791.100
131_W134_V0.096561.097
171_A175_A0.096121.092
109_L113_E0.096021.091
209_R213_A0.0961.091
220_P224_R0.095681.087
29_I100_T0.095451.084
149_Y153_R0.095071.080
31_A35_A0.094831.077
218_W221_W0.094641.075
155_Y159_M0.094191.070
80_R90_S0.093991.068
23_Q26_H0.093341.060
72_V79_V0.09321.059
81_G91_A0.092761.054
157_D225_L0.092631.052
53_F104_F0.092511.051
74_R88_P0.092391.050
41_D63_E0.092041.046
56_E64_E0.092041.046
128_Y152_F0.091471.039
46_R50_T0.091291.037
23_Q214_L0.090761.031
113_E118_P0.090351.026
50_T96_L0.090311.026
152_F155_Y0.090261.025
218_W224_R0.090181.024
87_V166_E0.090071.023
167_P213_A0.089761.020
176_D216_L0.089681.019
114_R205_L0.088851.009
22_L207_P0.087790.997
105_V119_L0.087710.996
125_E129_H0.087380.993
47_L206_L0.087280.992
222_W225_L0.086580.984
46_R76_H0.086250.980
29_I33_L0.084520.960
80_R88_P0.084220.957
125_E149_Y0.084190.956
185_P198_L0.083750.951
105_V152_F0.083670.951
54_V134_V0.083060.944
54_V152_F0.082810.941
36_T91_A0.082630.939
58_V201_L0.08250.937
75_M90_S0.082040.932
119_L127_Y0.082010.932
121_D149_Y0.081880.930
18_R107_S0.081850.930
166_E170_E0.079850.907
130_E133_Y0.079820.907
203_R216_L0.079790.906
172_R215_G0.079550.904
26_H159_M0.079540.904
102_A145_L0.079540.904
72_V138_L0.079520.903
112_Y116_G0.079190.900
204_A211_R0.078960.897
109_L119_L0.07890.896
36_T81_G0.078730.894
14_L17_G0.078540.892
25_A30_A0.078330.890
168_T171_A0.078290.889
172_R208_P0.078250.889
31_A168_T0.078230.889
25_A202_T0.078190.888
167_P172_R0.078190.888
100_T135_G0.077950.886
158_D221_W0.077680.882
50_T104_F0.077630.882
22_L206_L0.077530.881
21_L202_T0.077460.880
220_P225_L0.077260.878
21_L206_L0.076950.874
32_A36_T0.076910.874
101_L145_L0.076420.868
79_V89_I0.076310.867
183_A198_L0.076170.865
110_R197_L0.075910.862
73_R174_L0.075790.861
136_H145_L0.075510.858
18_R206_L0.075030.852
123_E147_A0.075020.852
49_R135_G0.074770.849
128_Y149_Y0.074740.849
34_V173_E0.074650.848
219_T224_R0.074560.847
26_H94_D0.074270.844
175_A179_L0.074190.843
21_L24_Y0.074150.842
39_F47_L0.074080.842
109_L127_Y0.073870.839
104_F131_W0.073860.839
33_L100_T0.073660.837
79_V91_A0.073620.836
218_W222_W0.073610.836
59_F130_E0.073580.836
24_Y104_F0.073560.836
25_A54_V0.073450.834
121_D129_H0.073260.832
49_R86_G0.073170.831
63_E67_A0.073120.831
126_A129_H0.073070.830
63_E88_P0.072980.829
88_P174_L0.072880.828
79_V112_Y0.072710.826
91_A138_L0.072590.825
47_L51_A0.07240.822
92_L218_W0.072330.822
50_T79_V0.07220.820
79_V153_R0.072060.819
200_A225_L0.072050.819
97_Y100_T0.071810.816
23_Q54_V0.071690.814
22_L68_A0.071450.812
212_D225_L0.071220.809
128_Y203_R0.071090.808
202_T218_W0.070940.806
38_R178_L0.07050.801
114_R125_E0.070340.799
31_A81_G0.070110.796
75_M209_R0.070040.796
147_A150_A0.069970.795
196_P225_L0.069280.787
73_R86_G0.069010.784
41_D122_A0.068970.784
74_R173_E0.068920.783
16_G72_V0.068890.783
64_E151_E0.068860.782
166_E208_P0.06880.782
29_I202_T0.068740.781
176_D217_P0.068740.781
125_E128_Y0.068710.781
103_T152_F0.068680.780
200_A204_A0.068670.780
16_G32_A0.068560.779
174_L198_L0.068560.779
41_D154_E0.068410.777
151_E196_P0.068120.774
67_A78_R0.06810.774
131_W145_L0.068050.773
15_G21_L0.067970.772
216_L221_W0.067940.772
22_L26_H0.067710.769
111_A214_L0.067550.767
77_A92_L0.067510.767
159_M194_L0.067370.765
67_A77_A0.067330.765
89_I101_L0.067260.764
204_A223_R0.067230.764
20_L131_W0.067110.762
112_Y119_L0.067070.762
34_V168_T0.066980.761
198_L214_L0.06690.760
203_R211_R0.066850.759
74_R143_D0.06680.759
88_P144_D0.066790.759
101_L140_V0.066770.759
72_V76_H0.066550.756
75_M131_W0.066530.756
63_E143_D0.06650.755
154_E157_D0.066470.755
15_G111_A0.066450.755
135_G138_L0.066330.754
116_G123_E0.066210.752
43_P100_T0.06610.751
159_M202_T0.0660.750
157_D160_L0.065950.749
33_L104_F0.065870.748
200_A218_W0.065860.748
123_E198_L0.065660.746
50_T100_T0.065630.746
62_G203_R0.065480.744
114_R127_Y0.065430.743
118_P122_A0.065430.743
84_P123_E0.06530.742
22_L36_T0.06520.741
72_V139_G0.06520.741
89_I94_D0.065170.740
67_A71_R0.065080.739
120_T148_T0.065080.739
68_A75_M0.0650.738
201_L220_P0.064910.737
217_P221_W0.064880.737
52_R132_R0.064870.737
16_G33_L0.064850.737
119_L216_L0.064840.737
96_L214_L0.064620.734
45_R100_T0.064370.731
104_F107_S0.064350.731
23_Q94_D0.064290.730
23_Q89_I0.06410.728
20_L50_T0.0640.727
68_A71_R0.063950.726
175_A213_A0.063930.726
34_V154_E0.063810.725
20_L100_T0.06380.725
96_L101_L0.06380.725
176_D180_D0.063630.723
165_L174_L0.063580.722
110_R153_R0.063520.722
32_A91_A0.063430.721
100_T139_G0.063410.720
22_L103_T0.063190.718
97_Y103_T0.063090.717
17_G25_A0.062870.714
218_W225_L0.062870.714
50_T135_G0.062830.714
20_L32_A0.062810.714
186_R193_P0.062810.714
90_S208_P0.062790.713
30_A174_L0.062680.712
125_E147_A0.062590.711
158_D223_R0.062490.710
114_R124_R0.062480.710
20_L27_P0.062440.709
159_M166_E0.062430.709
38_R42_D0.062350.708
15_G115_F0.062310.708
35_A89_I0.062290.708
36_T138_L0.062290.708
89_I95_M0.062270.707
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3ol3A0.442119.80.949
4a2qA0.4711120.953
2kvcA0.42567.60.957
2eqrA0.24796.80.958
1tc3C0.17775.10.96
2qrwA0.46284.60.961
4hrrB0.49174.50.961
4g6dA0.26034.10.962
1or4A0.512440.962
4iplA0.632240.962
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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